Retinal vessel oxygen saturation and its correlation with structural changes in retinitis pigmentosa
Purpose To study the influence of retinal structural changes on oxygen saturation in retinitis pigmentosa (RP) patients. Methods Oximetry measurements were performed on 21 eyes of 11 RP patients and compared to 24 eyes of 12 controls. Retinal oxygen saturation was measured in all major retinal arter...
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| Veröffentlicht in: | Acta ophthalmologica (Oxford, England) England), 2014-08, Vol.92 (5), p.454-460 |
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| creator | Türksever, Cengiz Valmaggia, Christophe Orgül, Selim Schorderet, Daniel F. Flammer, Josef Todorova, Margarita G. |
| description | Purpose
To study the influence of retinal structural changes on oxygen saturation in retinitis pigmentosa (RP) patients.
Methods
Oximetry measurements were performed on 21 eyes of 11 RP patients and compared to 24 eyes of 12 controls. Retinal oxygen saturation was measured in all major retinal arterioles (A‐SO2) and venules (V‐SO2) with an oximetry unit of the retinal vessel analyser (IMEDOS Systems UG, Jena, Germany). Oximetry data were compared with morphological changes measured by Cirrus optical coherence tomography (OCT) (Carl Zeiss Meditec, Dublin, CA, USA, macular thickness protocol).
Results
In RP patients, the retinal A‐SO2 and V‐SO2 levels were higher at 99.3% (p = 0.001, anova based on mixed‐effects model) and 66.8% (p |
| doi_str_mv | 10.1111/aos.12379 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1687685602</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1547523494</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4569-b9f67fd0e579c51d476edde257e6f85659dd05cf054c0bfe3a66f04132df2a0a3</originalsourceid><addsrcrecordid>eNqF0U9LHDEYBvBQKlW3HvoFSqAXe1hNMvmzcxSpVRAEteBtyCZv1sjsZJs3U91v7-yOehCkuSS8_HgI70PIN86O-HCObcIjLipTfyJ73Cg1rYyefX57q7tdso_4wJjmWssvZFdIo41ksz3ir6HEzrb0HyBCS9PTegEdRVv6bEtMHbWdp7EgdSlnaMfZYyz3FEvu3Ya11N3bbgFIY0fzJi-WiHQVF0voSkL7lewE2yIcvNwT8ufs1-3p-fTy6vfF6cnl1Eml6-m8DtoEz0CZ2inuh0-C9yCUAR1mSqvae6ZcYEo6Ng9QWa0Dk7wSPgjLbDUhh2PuKqe_PWBplhEdtK3tIPXYcD0bFqM0E_-nSholKlnLgf54Rx9Sn4edbZUyiguxUT9H5XJCzBCaVY5Lm9cNZ82mpWZoqdm2NNjvL4n9fAn-Tb7WMoDjETzGFtYfJzUnVzdj5DMA450n</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1545751224</pqid></control><display><type>article</type><title>Retinal vessel oxygen saturation and its correlation with structural changes in retinitis pigmentosa</title><source>Wiley Free Content</source><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Türksever, Cengiz ; Valmaggia, Christophe ; Orgül, Selim ; Schorderet, Daniel F. ; Flammer, Josef ; Todorova, Margarita G.</creator><creatorcontrib>Türksever, Cengiz ; Valmaggia, Christophe ; Orgül, Selim ; Schorderet, Daniel F. ; Flammer, Josef ; Todorova, Margarita G.</creatorcontrib><description>Purpose
To study the influence of retinal structural changes on oxygen saturation in retinitis pigmentosa (RP) patients.
Methods
Oximetry measurements were performed on 21 eyes of 11 RP patients and compared to 24 eyes of 12 controls. Retinal oxygen saturation was measured in all major retinal arterioles (A‐SO2) and venules (V‐SO2) with an oximetry unit of the retinal vessel analyser (IMEDOS Systems UG, Jena, Germany). Oximetry data were compared with morphological changes measured by Cirrus optical coherence tomography (OCT) (Carl Zeiss Meditec, Dublin, CA, USA, macular thickness protocol).
Results
In RP patients, the retinal A‐SO2 and V‐SO2 levels were higher at 99.3% (p = 0.001, anova based on mixed‐effects model) and 66.8% (p < 0.001), respectively, and the difference between the two (A‐V SO2) was lower at 32.5% (p < 0.001), when compared to the control group (92.4%; 54.0%; 38.4%, respectively). With the RP group, the A‐V SO2 correlated positively, not only with central macular thickness, but also with retinal thickness, in zones 2 and 3 (p = 0.006, p = 0.007, p = 0.014).
Conclusion
These data indicate that oxygen metabolism was altered in RP patients. Based on our preliminary results, retinal vessel saturation correlated with structural alterations in RP. This method could be valuable in monitoring disease progression and evaluating a potential therapeutic response.</description><identifier>ISSN: 1755-375X</identifier><identifier>EISSN: 1755-3768</identifier><identifier>DOI: 10.1111/aos.12379</identifier><identifier>PMID: 24767408</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Adult ; Blood Pressure - physiology ; Female ; Humans ; inner/outer segment junction line ; Intraocular Pressure - physiology ; Male ; Middle Aged ; Ophthalmology ; optical coherence tomography ; Oximetry ; oxygen ; Oxygen - blood ; Retina - pathology ; Retinal Artery - physiopathology ; Retinal Vein - physiopathology ; retinal vessel oximetry ; retinitis pigmentosa ; Retinitis Pigmentosa - pathology ; saturation ; Tomography, Optical Coherence</subject><ispartof>Acta ophthalmologica (Oxford, England), 2014-08, Vol.92 (5), p.454-460</ispartof><rights>2014 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd</rights><rights>2014 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.</rights><rights>Copyright © 2014 Acta Ophthalmologica Scandinavica Foundation</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4569-b9f67fd0e579c51d476edde257e6f85659dd05cf054c0bfe3a66f04132df2a0a3</citedby><cites>FETCH-LOGICAL-c4569-b9f67fd0e579c51d476edde257e6f85659dd05cf054c0bfe3a66f04132df2a0a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Faos.12379$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Faos.12379$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24767408$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Türksever, Cengiz</creatorcontrib><creatorcontrib>Valmaggia, Christophe</creatorcontrib><creatorcontrib>Orgül, Selim</creatorcontrib><creatorcontrib>Schorderet, Daniel F.</creatorcontrib><creatorcontrib>Flammer, Josef</creatorcontrib><creatorcontrib>Todorova, Margarita G.</creatorcontrib><title>Retinal vessel oxygen saturation and its correlation with structural changes in retinitis pigmentosa</title><title>Acta ophthalmologica (Oxford, England)</title><addtitle>Acta Ophthalmol</addtitle><description>Purpose
To study the influence of retinal structural changes on oxygen saturation in retinitis pigmentosa (RP) patients.
Methods
Oximetry measurements were performed on 21 eyes of 11 RP patients and compared to 24 eyes of 12 controls. Retinal oxygen saturation was measured in all major retinal arterioles (A‐SO2) and venules (V‐SO2) with an oximetry unit of the retinal vessel analyser (IMEDOS Systems UG, Jena, Germany). Oximetry data were compared with morphological changes measured by Cirrus optical coherence tomography (OCT) (Carl Zeiss Meditec, Dublin, CA, USA, macular thickness protocol).
Results
In RP patients, the retinal A‐SO2 and V‐SO2 levels were higher at 99.3% (p = 0.001, anova based on mixed‐effects model) and 66.8% (p < 0.001), respectively, and the difference between the two (A‐V SO2) was lower at 32.5% (p < 0.001), when compared to the control group (92.4%; 54.0%; 38.4%, respectively). With the RP group, the A‐V SO2 correlated positively, not only with central macular thickness, but also with retinal thickness, in zones 2 and 3 (p = 0.006, p = 0.007, p = 0.014).
Conclusion
These data indicate that oxygen metabolism was altered in RP patients. Based on our preliminary results, retinal vessel saturation correlated with structural alterations in RP. This method could be valuable in monitoring disease progression and evaluating a potential therapeutic response.</description><subject>Adult</subject><subject>Blood Pressure - physiology</subject><subject>Female</subject><subject>Humans</subject><subject>inner/outer segment junction line</subject><subject>Intraocular Pressure - physiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Ophthalmology</subject><subject>optical coherence tomography</subject><subject>Oximetry</subject><subject>oxygen</subject><subject>Oxygen - blood</subject><subject>Retina - pathology</subject><subject>Retinal Artery - physiopathology</subject><subject>Retinal Vein - physiopathology</subject><subject>retinal vessel oximetry</subject><subject>retinitis pigmentosa</subject><subject>Retinitis Pigmentosa - pathology</subject><subject>saturation</subject><subject>Tomography, Optical Coherence</subject><issn>1755-375X</issn><issn>1755-3768</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0U9LHDEYBvBQKlW3HvoFSqAXe1hNMvmzcxSpVRAEteBtyCZv1sjsZJs3U91v7-yOehCkuSS8_HgI70PIN86O-HCObcIjLipTfyJ73Cg1rYyefX57q7tdso_4wJjmWssvZFdIo41ksz3ir6HEzrb0HyBCS9PTegEdRVv6bEtMHbWdp7EgdSlnaMfZYyz3FEvu3Ya11N3bbgFIY0fzJi-WiHQVF0voSkL7lewE2yIcvNwT8ufs1-3p-fTy6vfF6cnl1Eml6-m8DtoEz0CZ2inuh0-C9yCUAR1mSqvae6ZcYEo6Ng9QWa0Dk7wSPgjLbDUhh2PuKqe_PWBplhEdtK3tIPXYcD0bFqM0E_-nSholKlnLgf54Rx9Sn4edbZUyiguxUT9H5XJCzBCaVY5Lm9cNZ82mpWZoqdm2NNjvL4n9fAn-Tb7WMoDjETzGFtYfJzUnVzdj5DMA450n</recordid><startdate>201408</startdate><enddate>201408</enddate><creator>Türksever, Cengiz</creator><creator>Valmaggia, Christophe</creator><creator>Orgül, Selim</creator><creator>Schorderet, Daniel F.</creator><creator>Flammer, Josef</creator><creator>Todorova, Margarita G.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>201408</creationdate><title>Retinal vessel oxygen saturation and its correlation with structural changes in retinitis pigmentosa</title><author>Türksever, Cengiz ; Valmaggia, Christophe ; Orgül, Selim ; Schorderet, Daniel F. ; Flammer, Josef ; Todorova, Margarita G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4569-b9f67fd0e579c51d476edde257e6f85659dd05cf054c0bfe3a66f04132df2a0a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Blood Pressure - physiology</topic><topic>Female</topic><topic>Humans</topic><topic>inner/outer segment junction line</topic><topic>Intraocular Pressure - physiology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Ophthalmology</topic><topic>optical coherence tomography</topic><topic>Oximetry</topic><topic>oxygen</topic><topic>Oxygen - blood</topic><topic>Retina - pathology</topic><topic>Retinal Artery - physiopathology</topic><topic>Retinal Vein - physiopathology</topic><topic>retinal vessel oximetry</topic><topic>retinitis pigmentosa</topic><topic>Retinitis Pigmentosa - pathology</topic><topic>saturation</topic><topic>Tomography, Optical Coherence</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Türksever, Cengiz</creatorcontrib><creatorcontrib>Valmaggia, Christophe</creatorcontrib><creatorcontrib>Orgül, Selim</creatorcontrib><creatorcontrib>Schorderet, Daniel F.</creatorcontrib><creatorcontrib>Flammer, Josef</creatorcontrib><creatorcontrib>Todorova, Margarita G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Acta ophthalmologica (Oxford, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Türksever, Cengiz</au><au>Valmaggia, Christophe</au><au>Orgül, Selim</au><au>Schorderet, Daniel F.</au><au>Flammer, Josef</au><au>Todorova, Margarita G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Retinal vessel oxygen saturation and its correlation with structural changes in retinitis pigmentosa</atitle><jtitle>Acta ophthalmologica (Oxford, England)</jtitle><addtitle>Acta Ophthalmol</addtitle><date>2014-08</date><risdate>2014</risdate><volume>92</volume><issue>5</issue><spage>454</spage><epage>460</epage><pages>454-460</pages><issn>1755-375X</issn><eissn>1755-3768</eissn><abstract>Purpose
To study the influence of retinal structural changes on oxygen saturation in retinitis pigmentosa (RP) patients.
Methods
Oximetry measurements were performed on 21 eyes of 11 RP patients and compared to 24 eyes of 12 controls. Retinal oxygen saturation was measured in all major retinal arterioles (A‐SO2) and venules (V‐SO2) with an oximetry unit of the retinal vessel analyser (IMEDOS Systems UG, Jena, Germany). Oximetry data were compared with morphological changes measured by Cirrus optical coherence tomography (OCT) (Carl Zeiss Meditec, Dublin, CA, USA, macular thickness protocol).
Results
In RP patients, the retinal A‐SO2 and V‐SO2 levels were higher at 99.3% (p = 0.001, anova based on mixed‐effects model) and 66.8% (p < 0.001), respectively, and the difference between the two (A‐V SO2) was lower at 32.5% (p < 0.001), when compared to the control group (92.4%; 54.0%; 38.4%, respectively). With the RP group, the A‐V SO2 correlated positively, not only with central macular thickness, but also with retinal thickness, in zones 2 and 3 (p = 0.006, p = 0.007, p = 0.014).
Conclusion
These data indicate that oxygen metabolism was altered in RP patients. Based on our preliminary results, retinal vessel saturation correlated with structural alterations in RP. This method could be valuable in monitoring disease progression and evaluating a potential therapeutic response.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>24767408</pmid><doi>10.1111/aos.12379</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Blood Pressure - physiology Female Humans inner/outer segment junction line Intraocular Pressure - physiology Male Middle Aged Ophthalmology optical coherence tomography Oximetry oxygen Oxygen - blood Retina - pathology Retinal Artery - physiopathology Retinal Vein - physiopathology retinal vessel oximetry retinitis pigmentosa Retinitis Pigmentosa - pathology saturation Tomography, Optical Coherence |
| title | Retinal vessel oxygen saturation and its correlation with structural changes in retinitis pigmentosa |
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