Effect of morphine on the reduced uteroplacental perfusion model of pre-eclampsia in rats
Abstract Objectives To investigate the effect of morphine on the reduced uteroplacental perfusion pressure (RUPP) model of pre-eclampsia in rats. Study design The abdominal aorta and ovarian arteries of pregnant rats were isolated and clipped on gestational day 14. The chronic morphine treatment gro...
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| Veröffentlicht in: | European journal of obstetrics & gynecology and reproductive biology 2013-06, Vol.168 (2), p.161-166 |
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| container_title | European journal of obstetrics & gynecology and reproductive biology |
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| creator | Javadian, P Salmanian, B Javadi-Paydar, M Shamshirsaz, A.A Ejtemaei Mehr, S Gharedaghi, M.H Dehpour, A.R |
| description | Abstract Objectives To investigate the effect of morphine on the reduced uteroplacental perfusion pressure (RUPP) model of pre-eclampsia in rats. Study design The abdominal aorta and ovarian arteries of pregnant rats were isolated and clipped on gestational day 14. The chronic morphine treatment group received naltrexone 5 mg/kg 1 h before each dose of morphine. L-nitromonomethylarginine 2 mg/kg was administrated in the same pattern. The control group received saline 10 ml/kg. Systolic blood pressure, blood urea nitrogen (BUN), creatinine, creatinine clearance, urinary protein, urinary nitrite/nitrate excretion, and fetal and placental weights were determined. Results Morphine significantly reduced systolic blood pressure, fetal and placental weights, plasma BUN, creatinine and urinary protein in RUPP rats compared with control rats. Urinary nitrite/nitrate excretion and creatinine clearance were significantly increased in response to morphine treatment. Conclusion Morphine reduced blood pressure and improved renal function in the RUPP model of pre-eclampsia, but this was associated with reduced fetal and placental weights. |
| doi_str_mv | 10.1016/j.ejogrb.2013.01.008 |
| format | Article |
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Study design The abdominal aorta and ovarian arteries of pregnant rats were isolated and clipped on gestational day 14. The chronic morphine treatment group received naltrexone 5 mg/kg 1 h before each dose of morphine. L-nitromonomethylarginine 2 mg/kg was administrated in the same pattern. The control group received saline 10 ml/kg. Systolic blood pressure, blood urea nitrogen (BUN), creatinine, creatinine clearance, urinary protein, urinary nitrite/nitrate excretion, and fetal and placental weights were determined. Results Morphine significantly reduced systolic blood pressure, fetal and placental weights, plasma BUN, creatinine and urinary protein in RUPP rats compared with control rats. Urinary nitrite/nitrate excretion and creatinine clearance were significantly increased in response to morphine treatment. Conclusion Morphine reduced blood pressure and improved renal function in the RUPP model of pre-eclampsia, but this was associated with reduced fetal and placental weights.</description><identifier>ISSN: 0301-2115</identifier><identifier>EISSN: 1872-7654</identifier><identifier>DOI: 10.1016/j.ejogrb.2013.01.008</identifier><identifier>PMID: 23398725</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Animal model ; Animals ; Antihypertensive Agents - adverse effects ; Antihypertensive Agents - antagonists & inhibitors ; Antihypertensive Agents - therapeutic use ; Disease Models, Animal ; Enzyme Inhibitors - pharmacology ; Female ; Fetal Development - drug effects ; Hypertension ; Kidney - drug effects ; Kidney - metabolism ; Kidney - physiopathology ; Morphine - adverse effects ; Morphine - antagonists & inhibitors ; Morphine - therapeutic use ; Narcotic Antagonists - pharmacology ; Nitrates - urine ; Nitric Oxide - metabolism ; Nitric Oxide Synthase - antagonists & inhibitors ; Nitrites - urine ; Obstetrics and Gynecology ; Opioids ; Placental Circulation - drug effects ; Placentation - drug effects ; Pre-eclampsia ; Pre-Eclampsia - drug therapy ; Pre-Eclampsia - metabolism ; Pre-Eclampsia - physiopathology ; Pregnancy ; Rats ; Rats, Sprague-Dawley ; Receptors, Opioid, mu - agonists ; Receptors, Opioid, mu - antagonists & inhibitors ; Renal Insufficiency - etiology ; Renal Insufficiency - prevention & control ; Up-Regulation - drug effects</subject><ispartof>European journal of obstetrics & gynecology and reproductive biology, 2013-06, Vol.168 (2), p.161-166</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2013 Elsevier Ireland Ltd</rights><rights>Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c450t-a4b01b7ca50e130efbb43d20dca9ae17b1258ac6da0c66177a7db65282796c5d3</citedby><cites>FETCH-LOGICAL-c450t-a4b01b7ca50e130efbb43d20dca9ae17b1258ac6da0c66177a7db65282796c5d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0301211513000481$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23398725$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Javadian, P</creatorcontrib><creatorcontrib>Salmanian, B</creatorcontrib><creatorcontrib>Javadi-Paydar, M</creatorcontrib><creatorcontrib>Shamshirsaz, A.A</creatorcontrib><creatorcontrib>Ejtemaei Mehr, S</creatorcontrib><creatorcontrib>Gharedaghi, M.H</creatorcontrib><creatorcontrib>Dehpour, A.R</creatorcontrib><title>Effect of morphine on the reduced uteroplacental perfusion model of pre-eclampsia in rats</title><title>European journal of obstetrics & gynecology and reproductive biology</title><addtitle>Eur J Obstet Gynecol Reprod Biol</addtitle><description>Abstract Objectives To investigate the effect of morphine on the reduced uteroplacental perfusion pressure (RUPP) model of pre-eclampsia in rats. Study design The abdominal aorta and ovarian arteries of pregnant rats were isolated and clipped on gestational day 14. The chronic morphine treatment group received naltrexone 5 mg/kg 1 h before each dose of morphine. L-nitromonomethylarginine 2 mg/kg was administrated in the same pattern. The control group received saline 10 ml/kg. Systolic blood pressure, blood urea nitrogen (BUN), creatinine, creatinine clearance, urinary protein, urinary nitrite/nitrate excretion, and fetal and placental weights were determined. Results Morphine significantly reduced systolic blood pressure, fetal and placental weights, plasma BUN, creatinine and urinary protein in RUPP rats compared with control rats. Urinary nitrite/nitrate excretion and creatinine clearance were significantly increased in response to morphine treatment. Conclusion Morphine reduced blood pressure and improved renal function in the RUPP model of pre-eclampsia, but this was associated with reduced fetal and placental weights.</description><subject>Animal model</subject><subject>Animals</subject><subject>Antihypertensive Agents - adverse effects</subject><subject>Antihypertensive Agents - antagonists & inhibitors</subject><subject>Antihypertensive Agents - therapeutic use</subject><subject>Disease Models, Animal</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>Female</subject><subject>Fetal Development - drug effects</subject><subject>Hypertension</subject><subject>Kidney - drug effects</subject><subject>Kidney - metabolism</subject><subject>Kidney - physiopathology</subject><subject>Morphine - adverse effects</subject><subject>Morphine - antagonists & inhibitors</subject><subject>Morphine - therapeutic use</subject><subject>Narcotic Antagonists - pharmacology</subject><subject>Nitrates - urine</subject><subject>Nitric Oxide - metabolism</subject><subject>Nitric Oxide Synthase - antagonists & inhibitors</subject><subject>Nitrites - urine</subject><subject>Obstetrics and Gynecology</subject><subject>Opioids</subject><subject>Placental Circulation - drug effects</subject><subject>Placentation - drug effects</subject><subject>Pre-eclampsia</subject><subject>Pre-Eclampsia - drug therapy</subject><subject>Pre-Eclampsia - metabolism</subject><subject>Pre-Eclampsia - physiopathology</subject><subject>Pregnancy</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptors, Opioid, mu - agonists</subject><subject>Receptors, Opioid, mu - antagonists & inhibitors</subject><subject>Renal Insufficiency - etiology</subject><subject>Renal Insufficiency - prevention & control</subject><subject>Up-Regulation - drug effects</subject><issn>0301-2115</issn><issn>1872-7654</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkj9v1jAQhy0Eoi-Fb4BQRpaEOyexkwUJVeWPVIkBGJgsx75QBycOdoLUb4-jtzCw9JZbnt-d9Nwx9hKhQkDxZqpoCj_iUHHAugKsALpH7ISd5KUUbfOYnaAGLDlie8GepTRBrrrun7ILnlvm2hP7fj2OZLYijMUc4nrrFirCUmy3VESyuyFb7BvFsHptaNm0L1aK455chuZgyR_JNVJJxut5TU4Xbimi3tJz9mTUPtGL-37Jvr2__nr1sbz5_OHT1bub0jQtbKVuBsBBGt0CYQ00DkNTWw7W6F4TygF522kjrAYjBEqppR1Eyzsue2FaW1-y1-e5awy_dkqbml0y5L1eKOxJoeikkFJg_zBai0ZC1_M2o80ZNTGkFGlUa3SzjncKQR3-1aTO_tXhXwGq7D_HXt1v2IeZ7L_QX-EZeHsGKCv57SiqZBwt2bOL-Q7KBvfQhv8HGO8WZ7T_SXeUprDHJetWqBJXoL4cP3C8QHYL0HRY_wFyqa1B</recordid><startdate>20130601</startdate><enddate>20130601</enddate><creator>Javadian, P</creator><creator>Salmanian, B</creator><creator>Javadi-Paydar, M</creator><creator>Shamshirsaz, A.A</creator><creator>Ejtemaei Mehr, S</creator><creator>Gharedaghi, M.H</creator><creator>Dehpour, A.R</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20130601</creationdate><title>Effect of morphine on the reduced uteroplacental perfusion model of pre-eclampsia in rats</title><author>Javadian, P ; Salmanian, B ; Javadi-Paydar, M ; Shamshirsaz, A.A ; Ejtemaei Mehr, S ; Gharedaghi, M.H ; Dehpour, A.R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c450t-a4b01b7ca50e130efbb43d20dca9ae17b1258ac6da0c66177a7db65282796c5d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animal model</topic><topic>Animals</topic><topic>Antihypertensive Agents - adverse effects</topic><topic>Antihypertensive Agents - antagonists & inhibitors</topic><topic>Antihypertensive Agents - therapeutic use</topic><topic>Disease Models, Animal</topic><topic>Enzyme Inhibitors - pharmacology</topic><topic>Female</topic><topic>Fetal Development - drug effects</topic><topic>Hypertension</topic><topic>Kidney - drug effects</topic><topic>Kidney - metabolism</topic><topic>Kidney - physiopathology</topic><topic>Morphine - adverse effects</topic><topic>Morphine - antagonists & inhibitors</topic><topic>Morphine - therapeutic use</topic><topic>Narcotic Antagonists - pharmacology</topic><topic>Nitrates - urine</topic><topic>Nitric Oxide - metabolism</topic><topic>Nitric Oxide Synthase - antagonists & inhibitors</topic><topic>Nitrites - urine</topic><topic>Obstetrics and Gynecology</topic><topic>Opioids</topic><topic>Placental Circulation - drug effects</topic><topic>Placentation - drug effects</topic><topic>Pre-eclampsia</topic><topic>Pre-Eclampsia - drug therapy</topic><topic>Pre-Eclampsia - metabolism</topic><topic>Pre-Eclampsia - physiopathology</topic><topic>Pregnancy</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Receptors, Opioid, mu - agonists</topic><topic>Receptors, Opioid, mu - antagonists & inhibitors</topic><topic>Renal Insufficiency - etiology</topic><topic>Renal Insufficiency - prevention & control</topic><topic>Up-Regulation - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Javadian, P</creatorcontrib><creatorcontrib>Salmanian, B</creatorcontrib><creatorcontrib>Javadi-Paydar, M</creatorcontrib><creatorcontrib>Shamshirsaz, A.A</creatorcontrib><creatorcontrib>Ejtemaei Mehr, S</creatorcontrib><creatorcontrib>Gharedaghi, M.H</creatorcontrib><creatorcontrib>Dehpour, A.R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>European journal of obstetrics & gynecology and reproductive biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Javadian, P</au><au>Salmanian, B</au><au>Javadi-Paydar, M</au><au>Shamshirsaz, A.A</au><au>Ejtemaei Mehr, S</au><au>Gharedaghi, M.H</au><au>Dehpour, A.R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of morphine on the reduced uteroplacental perfusion model of pre-eclampsia in rats</atitle><jtitle>European journal of obstetrics & gynecology and reproductive biology</jtitle><addtitle>Eur J Obstet Gynecol Reprod Biol</addtitle><date>2013-06-01</date><risdate>2013</risdate><volume>168</volume><issue>2</issue><spage>161</spage><epage>166</epage><pages>161-166</pages><issn>0301-2115</issn><eissn>1872-7654</eissn><abstract>Abstract Objectives To investigate the effect of morphine on the reduced uteroplacental perfusion pressure (RUPP) model of pre-eclampsia in rats. Study design The abdominal aorta and ovarian arteries of pregnant rats were isolated and clipped on gestational day 14. The chronic morphine treatment group received naltrexone 5 mg/kg 1 h before each dose of morphine. L-nitromonomethylarginine 2 mg/kg was administrated in the same pattern. The control group received saline 10 ml/kg. Systolic blood pressure, blood urea nitrogen (BUN), creatinine, creatinine clearance, urinary protein, urinary nitrite/nitrate excretion, and fetal and placental weights were determined. Results Morphine significantly reduced systolic blood pressure, fetal and placental weights, plasma BUN, creatinine and urinary protein in RUPP rats compared with control rats. Urinary nitrite/nitrate excretion and creatinine clearance were significantly increased in response to morphine treatment. Conclusion Morphine reduced blood pressure and improved renal function in the RUPP model of pre-eclampsia, but this was associated with reduced fetal and placental weights.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>23398725</pmid><doi>10.1016/j.ejogrb.2013.01.008</doi><tpages>6</tpages></addata></record> |
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| ispartof | European journal of obstetrics & gynecology and reproductive biology, 2013-06, Vol.168 (2), p.161-166 |
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| subjects | Animal model Animals Antihypertensive Agents - adverse effects Antihypertensive Agents - antagonists & inhibitors Antihypertensive Agents - therapeutic use Disease Models, Animal Enzyme Inhibitors - pharmacology Female Fetal Development - drug effects Hypertension Kidney - drug effects Kidney - metabolism Kidney - physiopathology Morphine - adverse effects Morphine - antagonists & inhibitors Morphine - therapeutic use Narcotic Antagonists - pharmacology Nitrates - urine Nitric Oxide - metabolism Nitric Oxide Synthase - antagonists & inhibitors Nitrites - urine Obstetrics and Gynecology Opioids Placental Circulation - drug effects Placentation - drug effects Pre-eclampsia Pre-Eclampsia - drug therapy Pre-Eclampsia - metabolism Pre-Eclampsia - physiopathology Pregnancy Rats Rats, Sprague-Dawley Receptors, Opioid, mu - agonists Receptors, Opioid, mu - antagonists & inhibitors Renal Insufficiency - etiology Renal Insufficiency - prevention & control Up-Regulation - drug effects |
| title | Effect of morphine on the reduced uteroplacental perfusion model of pre-eclampsia in rats |
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