Manadosterols A and B, Sulfonated Sterol Dimers Inhibiting the Ubc13–Uev1A Interaction, Isolated from the Marine Sponge Lissodendryx fibrosa

Two new dimeric sterols, manadosterols A (1) and B (2), were isolated from the marine sponge Lissodendryx fibrosa collected in Indonesia. The two compounds are comprised of two sulfonated sterol cores connected through the respective side chains. Manadosterols A (1) and B (2) inhibited the Ubc13-Uev...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2012-08, Vol.75 (8), p.1495-1499
Hauptverfasser:	Ushiyama, Shuntaro, Umaoka, Hideharu, Kato, Hikaru, Suwa, Yoshiaki, Morioka, Hiroshi, Rotinsulu, Henki, Losung, Fitje, Mangindaan, Remy E. P, de Voogd, Nicole J, Yokosawa, Hideyoshi, Tsukamoto, Sachiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Drug Screening Assays, Antitumor Indonesia Inhibitory Concentration 50 Marine Biology Molecular Structure Porifera - chemistry Sphingolipids - pharmacology Sterols - chemistry Sterols - isolation & purification Sterols - pharmacology
Online-Zugang:	Volltext
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