Diterpenes with Unprecedented Skeletons from the Red Alga Sphaerococcus coronopifolius
Three previously unknown diterpenes – spirosphaerol (1), anthrasphaerol (2) and corfusphaeroxide (3) – have been isolated from the red alga Sphaerococcus coronopifolius. Their structures were elucidated by spectral analysis, including NMR and MS. The isolated metabolites were evaluated for their in...
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| Veröffentlicht in: | European journal of organic chemistry 2015-05, Vol.2015 (13), p.2848-2853 |
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| container_title | European journal of organic chemistry |
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| creator | Smyrniotopoulos, Vangelis Kiss, Robert Mathieu, Véronique Vagias, Constantinos Roussis, Vassilios |
| description | Three previously unknown diterpenes – spirosphaerol (1), anthrasphaerol (2) and corfusphaeroxide (3) – have been isolated from the red alga Sphaerococcus coronopifolius. Their structures were elucidated by spectral analysis, including NMR and MS. The isolated metabolites were evaluated for their in vitro antitumour activities against one murine and five human cancer cell lines.
Chemical investigation of the red alga Sphaerococcus coronopifolius led to the isolation and structure elucidation of the three new minor metabolites 1–3, featuring rearranged tricyclic diterpene skeletons. The in vitro antitumour activities of 1–3 were evaluated against one murine cancer cell line and five human cancer cell lines. |
| doi_str_mv | 10.1002/ejoc.201500133 |
| format | Article |
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Chemical investigation of the red alga Sphaerococcus coronopifolius led to the isolation and structure elucidation of the three new minor metabolites 1–3, featuring rearranged tricyclic diterpene skeletons. The in vitro antitumour activities of 1–3 were evaluated against one murine cancer cell line and five human cancer cell lines.</description><identifier>ISSN: 1434-193X</identifier><identifier>EISSN: 1099-0690</identifier><identifier>DOI: 10.1002/ejoc.201500133</identifier><language>eng</language><publisher>Weinheim: WILEY-VCH Verlag</publisher><subject>Diterpenes ; Natural products ; Sphaerococcus coronopifolius ; Structure elucidation ; Terpenoids</subject><ispartof>European journal of organic chemistry, 2015-05, Vol.2015 (13), p.2848-2853</ispartof><rights>Copyright © 2015 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>Copyright © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3883-9915b09c97d75fbea98eb7ecc11de0e9791be9368a8323911dc70c402ce3c8ca3</citedby><cites>FETCH-LOGICAL-c3883-9915b09c97d75fbea98eb7ecc11de0e9791be9368a8323911dc70c402ce3c8ca3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fejoc.201500133$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fejoc.201500133$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,782,786,1419,27933,27934,45583,45584</link.rule.ids></links><search><creatorcontrib>Smyrniotopoulos, Vangelis</creatorcontrib><creatorcontrib>Kiss, Robert</creatorcontrib><creatorcontrib>Mathieu, Véronique</creatorcontrib><creatorcontrib>Vagias, Constantinos</creatorcontrib><creatorcontrib>Roussis, Vassilios</creatorcontrib><title>Diterpenes with Unprecedented Skeletons from the Red Alga Sphaerococcus coronopifolius</title><title>European journal of organic chemistry</title><addtitle>Eur. J. Org. Chem</addtitle><description>Three previously unknown diterpenes – spirosphaerol (1), anthrasphaerol (2) and corfusphaeroxide (3) – have been isolated from the red alga Sphaerococcus coronopifolius. Their structures were elucidated by spectral analysis, including NMR and MS. The isolated metabolites were evaluated for their in vitro antitumour activities against one murine and five human cancer cell lines.
Chemical investigation of the red alga Sphaerococcus coronopifolius led to the isolation and structure elucidation of the three new minor metabolites 1–3, featuring rearranged tricyclic diterpene skeletons. The in vitro antitumour activities of 1–3 were evaluated against one murine cancer cell line and five human cancer cell lines.</description><subject>Diterpenes</subject><subject>Natural products</subject><subject>Sphaerococcus coronopifolius</subject><subject>Structure elucidation</subject><subject>Terpenoids</subject><issn>1434-193X</issn><issn>1099-0690</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNqFkE1Lw0AQhoMo-Hn1HPDiJXW222QzR6mfpSho_cDLsp1ObGqajbsJ6r93pSLixdMMw_O8DG8U7QvoCYD-ES8s9fogUgAh5Vq0JQAxgQxhPewDOUgEysfNaNv7BQBglomt6P6kbNk1XLOP38p2Ht_VjWPiGdctz-LbF664tbWPC2eXcTvn-Cacj6tnE982c8POkiXqfEzW2do2ZWGrsvO70UZhKs9733Mnujs7nQwvkvH1-eXweJyQzHOZIIp0CkioZiotpmww56liIiFmDIwKxZRRZrnJZV9iuJICGkCfWFJORu5Eh6vcxtnXjn2rl6UnripTs-28FlmuMhUCREAP_qAL27k6fBcoNZAoUeWB6q0octZ7x4VuXLk07kML0F8166-a9U_NQcCV8FZW_PEPrU9H18PfbrJyS9_y-49r3IsOT6tUP1yd6_uTdDJ6usr0RH4C7cWROA</recordid><startdate>201505</startdate><enddate>201505</enddate><creator>Smyrniotopoulos, Vangelis</creator><creator>Kiss, Robert</creator><creator>Mathieu, Véronique</creator><creator>Vagias, Constantinos</creator><creator>Roussis, Vassilios</creator><general>WILEY-VCH Verlag</general><general>WILEY‐VCH Verlag</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>M7N</scope></search><sort><creationdate>201505</creationdate><title>Diterpenes with Unprecedented Skeletons from the Red Alga Sphaerococcus coronopifolius</title><author>Smyrniotopoulos, Vangelis ; Kiss, Robert ; Mathieu, Véronique ; Vagias, Constantinos ; Roussis, Vassilios</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3883-9915b09c97d75fbea98eb7ecc11de0e9791be9368a8323911dc70c402ce3c8ca3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Diterpenes</topic><topic>Natural products</topic><topic>Sphaerococcus coronopifolius</topic><topic>Structure elucidation</topic><topic>Terpenoids</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Smyrniotopoulos, Vangelis</creatorcontrib><creatorcontrib>Kiss, Robert</creatorcontrib><creatorcontrib>Mathieu, Véronique</creatorcontrib><creatorcontrib>Vagias, Constantinos</creatorcontrib><creatorcontrib>Roussis, Vassilios</creatorcontrib><collection>Istex</collection><collection>CrossRef</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><jtitle>European journal of organic chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Smyrniotopoulos, Vangelis</au><au>Kiss, Robert</au><au>Mathieu, Véronique</au><au>Vagias, Constantinos</au><au>Roussis, Vassilios</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diterpenes with Unprecedented Skeletons from the Red Alga Sphaerococcus coronopifolius</atitle><jtitle>European journal of organic chemistry</jtitle><addtitle>Eur. J. Org. Chem</addtitle><date>2015-05</date><risdate>2015</risdate><volume>2015</volume><issue>13</issue><spage>2848</spage><epage>2853</epage><pages>2848-2853</pages><issn>1434-193X</issn><eissn>1099-0690</eissn><abstract>Three previously unknown diterpenes – spirosphaerol (1), anthrasphaerol (2) and corfusphaeroxide (3) – have been isolated from the red alga Sphaerococcus coronopifolius. Their structures were elucidated by spectral analysis, including NMR and MS. The isolated metabolites were evaluated for their in vitro antitumour activities against one murine and five human cancer cell lines.
Chemical investigation of the red alga Sphaerococcus coronopifolius led to the isolation and structure elucidation of the three new minor metabolites 1–3, featuring rearranged tricyclic diterpene skeletons. The in vitro antitumour activities of 1–3 were evaluated against one murine cancer cell line and five human cancer cell lines.</abstract><cop>Weinheim</cop><pub>WILEY-VCH Verlag</pub><doi>10.1002/ejoc.201500133</doi><tpages>6</tpages></addata></record> |
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| subjects | Diterpenes Natural products Sphaerococcus coronopifolius Structure elucidation Terpenoids |
| title | Diterpenes with Unprecedented Skeletons from the Red Alga Sphaerococcus coronopifolius |
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