Potential role for snoRNAs in PKR activation during metabolic stress

Protein kinase RNA-activated (PKR) has long been known to be activated by viral double-stranded RNA (dsRNA) as part of the mammalian immune response. However, in mice PKR is also activated by metabolic stress in the absence of viral infection, and this requires a functional kinase domain, as well as...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2015-04, Vol.112 (16), p.5023-5028
Hauptverfasser:	Youssef, Osama A., Safran, Sarah A., Nakamura, Takahisa, Nix, David A., Hotamisligil, Gökhan S., Bass, Brenda L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Sciences cell death Cell Extracts Cells CHO Cells Cricetinae Cricetulus eIF-2 Kinase - metabolism Enzyme Activation - drug effects Immunoprecipitation Kinases lipids Medical treatment Mice Mutation non-coding RNA obesity Palmitic Acid - pharmacology protein synthesis Reproducibility of Results Ribonucleic acid RNA RNA, Small Nucleolar - metabolism Rodents Stress, Physiological - drug effects Viral infections
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