HIV-1 Infection and Antibodies to Plasmodium falciparum in Adults
Background. Coinfection with human immunodeficiency virus (HIV) may increase susceptibility to malaria by compromising naturally acquired immunity. Methods. In 339 adults (64% HIV infected), we measured antibodies to Plasmodium falciparum variant surface antigens (VSA) and antibodies that opsonise i...
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| Veröffentlicht in: | The Journal of infectious diseases 2014-11, Vol.210 (9), p.1407-1414 |
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| creator | Hasang, Wina Dembo, Edson G. Wijesinghe, Rushika Molyneux, Malcolm E. Kublin, James G. Rogerson, Stephen |
| description | Background. Coinfection with human immunodeficiency virus (HIV) may increase susceptibility to malaria by compromising naturally acquired immunity. Methods. In 339 adults (64% HIV infected), we measured antibodies to Plasmodium falciparum variant surface antigens (VSA) and antibodies that opsonise infected erythrocytes using parasite lines FCR3, E8B, and R29, and antibodies to merozoite antigens AMA-1 and MSP2. We determined the relationship between malaria antibodies, HIV infection, markers of immune compromise, and risk of incident parasitemia. Results. HIV-infected adults had significantly lower mean levels of opsonizing antibody to all parasite lines (P < .0001), and lower levels of antibody to AMA-1 (P = .01) and MSP2 (P < .0001). Levels of immunoglobulin G (IgG) to VSA were not affected by HIV status. Opsonising antibody titres against some isolates were positively correlated with CD4 count. There were negative associations between human immunodeficiency virus type 1 (HIV-1) viral load and opsonizing antibodies to FCR3 (P = .04), and levels of IgG to AMA-1 (P ≤ .03) and MSP2-3D7 (P = .05). Lower opsonizing antibody levels on enrollment were seen in those who became parasitemic during follow-up, independent of HIV infection (P < .04 for each line). Conclusions. HIV-1 infection decreases opsonizing antibodies to VSA, and antibody to merozoite antigens. Opsonizing antibodies were associated with lack of parasitemia during follow up, suggesting a role in protection. |
| doi_str_mv | 10.1093/infdis/jiu262 |
| format | Article |
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Coinfection with human immunodeficiency virus (HIV) may increase susceptibility to malaria by compromising naturally acquired immunity. Methods. In 339 adults (64% HIV infected), we measured antibodies to Plasmodium falciparum variant surface antigens (VSA) and antibodies that opsonise infected erythrocytes using parasite lines FCR3, E8B, and R29, and antibodies to merozoite antigens AMA-1 and MSP2. We determined the relationship between malaria antibodies, HIV infection, markers of immune compromise, and risk of incident parasitemia. Results. HIV-infected adults had significantly lower mean levels of opsonizing antibody to all parasite lines (P < .0001), and lower levels of antibody to AMA-1 (P = .01) and MSP2 (P < .0001). Levels of immunoglobulin G (IgG) to VSA were not affected by HIV status. Opsonising antibody titres against some isolates were positively correlated with CD4 count. There were negative associations between human immunodeficiency virus type 1 (HIV-1) viral load and opsonizing antibodies to FCR3 (P = .04), and levels of IgG to AMA-1 (P ≤ .03) and MSP2-3D7 (P = .05). Lower opsonizing antibody levels on enrollment were seen in those who became parasitemic during follow-up, independent of HIV infection (P < .04 for each line). Conclusions. HIV-1 infection decreases opsonizing antibodies to VSA, and antibody to merozoite antigens. Opsonizing antibodies were associated with lack of parasitemia during follow up, suggesting a role in protection.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/jiu262</identifier><identifier>PMID: 24795481</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>Adolescent ; Adult ; Aged ; Antibodies ; Antibodies, Protozoan - immunology ; Antigens ; Antigens, Protozoan - immunology ; Case-Control Studies ; CD4 Lymphocyte Count ; Coinfection - immunology ; Coinfection - parasitology ; Coinfection - virology ; Erythrocytes ; Female ; HIV ; HIV 1 ; HIV infections ; HIV Infections - complications ; HIV Infections - immunology ; HIV Infections - parasitology ; HIV/AIDS ; Human immunodeficiency virus ; Human immunodeficiency virus 1 ; Humans ; Immunoglobulin G - immunology ; Malaria ; Malaria, Falciparum - complications ; Malaria, Falciparum - immunology ; Malaria, Falciparum - virology ; Male ; Merozoites ; Middle Aged ; Parasitemia ; Parasites ; Plasmodium falciparum ; Plasmodium falciparum - immunology ; Young Adult</subject><ispartof>The Journal of infectious diseases, 2014-11, Vol.210 (9), p.1407-1414</ispartof><rights>Copyright © 2014 Oxford University Press on behalf of the Infectious Diseases Society of America</rights><rights>The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c317t-c92629556f69131f0cf8f5e5b54bdbd067086731ecc6c93f4b514bf0c5bb0fb43</citedby><cites>FETCH-LOGICAL-c317t-c92629556f69131f0cf8f5e5b54bdbd067086731ecc6c93f4b514bf0c5bb0fb43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/43708072$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/43708072$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24795481$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hasang, Wina</creatorcontrib><creatorcontrib>Dembo, Edson G.</creatorcontrib><creatorcontrib>Wijesinghe, Rushika</creatorcontrib><creatorcontrib>Molyneux, Malcolm E.</creatorcontrib><creatorcontrib>Kublin, James G.</creatorcontrib><creatorcontrib>Rogerson, Stephen</creatorcontrib><title>HIV-1 Infection and Antibodies to Plasmodium falciparum in Adults</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>Background. Coinfection with human immunodeficiency virus (HIV) may increase susceptibility to malaria by compromising naturally acquired immunity. Methods. In 339 adults (64% HIV infected), we measured antibodies to Plasmodium falciparum variant surface antigens (VSA) and antibodies that opsonise infected erythrocytes using parasite lines FCR3, E8B, and R29, and antibodies to merozoite antigens AMA-1 and MSP2. We determined the relationship between malaria antibodies, HIV infection, markers of immune compromise, and risk of incident parasitemia. Results. HIV-infected adults had significantly lower mean levels of opsonizing antibody to all parasite lines (P < .0001), and lower levels of antibody to AMA-1 (P = .01) and MSP2 (P < .0001). Levels of immunoglobulin G (IgG) to VSA were not affected by HIV status. Opsonising antibody titres against some isolates were positively correlated with CD4 count. There were negative associations between human immunodeficiency virus type 1 (HIV-1) viral load and opsonizing antibodies to FCR3 (P = .04), and levels of IgG to AMA-1 (P ≤ .03) and MSP2-3D7 (P = .05). Lower opsonizing antibody levels on enrollment were seen in those who became parasitemic during follow-up, independent of HIV infection (P < .04 for each line). Conclusions. HIV-1 infection decreases opsonizing antibodies to VSA, and antibody to merozoite antigens. Opsonizing antibodies were associated with lack of parasitemia during follow up, suggesting a role in protection.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Antibodies</subject><subject>Antibodies, Protozoan - immunology</subject><subject>Antigens</subject><subject>Antigens, Protozoan - immunology</subject><subject>Case-Control Studies</subject><subject>CD4 Lymphocyte Count</subject><subject>Coinfection - immunology</subject><subject>Coinfection - parasitology</subject><subject>Coinfection - virology</subject><subject>Erythrocytes</subject><subject>Female</subject><subject>HIV</subject><subject>HIV 1</subject><subject>HIV infections</subject><subject>HIV Infections - complications</subject><subject>HIV Infections - immunology</subject><subject>HIV Infections - parasitology</subject><subject>HIV/AIDS</subject><subject>Human immunodeficiency virus</subject><subject>Human immunodeficiency virus 1</subject><subject>Humans</subject><subject>Immunoglobulin G - immunology</subject><subject>Malaria</subject><subject>Malaria, Falciparum - complications</subject><subject>Malaria, Falciparum - immunology</subject><subject>Malaria, Falciparum - virology</subject><subject>Male</subject><subject>Merozoites</subject><subject>Middle Aged</subject><subject>Parasitemia</subject><subject>Parasites</subject><subject>Plasmodium falciparum</subject><subject>Plasmodium falciparum - immunology</subject><subject>Young Adult</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkD1PwzAQhi0EoqUwMoIysoT6_BmPUQU0UiUYgDWKHVtylY8SJwP_HqOUzkx3Zz96dfcgdAv4EbCia9-52of13k9EkDO0BE5lKgTQc7TEmJAUMqUW6CqEPcaYUSEv0YIwqTjLYInybfGZQlJ0zprR911SdXWSd6PXfe1tSMY-eWuq0MZpahNXNcYfqiG2vkvyemrGcI0u4nOwN8e6Qh_PT--bbbp7fSk2-S41FOSYGhX3U5wLJxRQcNi4zHHLNWe61jUWEmdCUrDGCKOoY5oD0xHjWmOnGV2hhzn3MPRfkw1j2fpgbNNUne2nUILIZAzBVP4DBUIUBkkjms6oGfoQBuvKw-DbavguAZe_gstZcDkLjvz9MXrSra1P9J_RCNzNwD6M_XD6ZzTehyWhPxocgK0</recordid><startdate>20141101</startdate><enddate>20141101</enddate><creator>Hasang, Wina</creator><creator>Dembo, Edson G.</creator><creator>Wijesinghe, Rushika</creator><creator>Molyneux, Malcolm E.</creator><creator>Kublin, James G.</creator><creator>Rogerson, Stephen</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7U9</scope><scope>C1K</scope><scope>F1W</scope><scope>H94</scope><scope>H95</scope><scope>H97</scope><scope>L.G</scope><scope>M7N</scope></search><sort><creationdate>20141101</creationdate><title>HIV-1 Infection and Antibodies to Plasmodium falciparum in Adults</title><author>Hasang, Wina ; Dembo, Edson G. ; Wijesinghe, Rushika ; Molyneux, Malcolm E. ; Kublin, James G. ; Rogerson, Stephen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c317t-c92629556f69131f0cf8f5e5b54bdbd067086731ecc6c93f4b514bf0c5bb0fb43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Antibodies</topic><topic>Antibodies, Protozoan - immunology</topic><topic>Antigens</topic><topic>Antigens, Protozoan - immunology</topic><topic>Case-Control Studies</topic><topic>CD4 Lymphocyte Count</topic><topic>Coinfection - immunology</topic><topic>Coinfection - parasitology</topic><topic>Coinfection - virology</topic><topic>Erythrocytes</topic><topic>Female</topic><topic>HIV</topic><topic>HIV 1</topic><topic>HIV infections</topic><topic>HIV Infections - complications</topic><topic>HIV Infections - immunology</topic><topic>HIV Infections - parasitology</topic><topic>HIV/AIDS</topic><topic>Human immunodeficiency virus</topic><topic>Human immunodeficiency virus 1</topic><topic>Humans</topic><topic>Immunoglobulin G - immunology</topic><topic>Malaria</topic><topic>Malaria, Falciparum - complications</topic><topic>Malaria, Falciparum - immunology</topic><topic>Malaria, Falciparum - virology</topic><topic>Male</topic><topic>Merozoites</topic><topic>Middle Aged</topic><topic>Parasitemia</topic><topic>Parasites</topic><topic>Plasmodium falciparum</topic><topic>Plasmodium falciparum - immunology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hasang, Wina</creatorcontrib><creatorcontrib>Dembo, Edson G.</creatorcontrib><creatorcontrib>Wijesinghe, Rushika</creatorcontrib><creatorcontrib>Molyneux, Malcolm E.</creatorcontrib><creatorcontrib>Kublin, James G.</creatorcontrib><creatorcontrib>Rogerson, Stephen</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hasang, Wina</au><au>Dembo, Edson G.</au><au>Wijesinghe, Rushika</au><au>Molyneux, Malcolm E.</au><au>Kublin, James G.</au><au>Rogerson, Stephen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HIV-1 Infection and Antibodies to Plasmodium falciparum in Adults</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>2014-11-01</date><risdate>2014</risdate><volume>210</volume><issue>9</issue><spage>1407</spage><epage>1414</epage><pages>1407-1414</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><abstract>Background. Coinfection with human immunodeficiency virus (HIV) may increase susceptibility to malaria by compromising naturally acquired immunity. Methods. In 339 adults (64% HIV infected), we measured antibodies to Plasmodium falciparum variant surface antigens (VSA) and antibodies that opsonise infected erythrocytes using parasite lines FCR3, E8B, and R29, and antibodies to merozoite antigens AMA-1 and MSP2. We determined the relationship between malaria antibodies, HIV infection, markers of immune compromise, and risk of incident parasitemia. Results. HIV-infected adults had significantly lower mean levels of opsonizing antibody to all parasite lines (P < .0001), and lower levels of antibody to AMA-1 (P = .01) and MSP2 (P < .0001). Levels of immunoglobulin G (IgG) to VSA were not affected by HIV status. Opsonising antibody titres against some isolates were positively correlated with CD4 count. There were negative associations between human immunodeficiency virus type 1 (HIV-1) viral load and opsonizing antibodies to FCR3 (P = .04), and levels of IgG to AMA-1 (P ≤ .03) and MSP2-3D7 (P = .05). Lower opsonizing antibody levels on enrollment were seen in those who became parasitemic during follow-up, independent of HIV infection (P < .04 for each line). Conclusions. HIV-1 infection decreases opsonizing antibodies to VSA, and antibody to merozoite antigens. Opsonizing antibodies were associated with lack of parasitemia during follow up, suggesting a role in protection.</abstract><cop>United States</cop><pub>Oxford University Press</pub><pmid>24795481</pmid><doi>10.1093/infdis/jiu262</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | Jstor Complete Legacy; Oxford University Press Journals All Titles (1996-Current); MEDLINE; Alma/SFX Local Collection |
| subjects | Adolescent Adult Aged Antibodies Antibodies, Protozoan - immunology Antigens Antigens, Protozoan - immunology Case-Control Studies CD4 Lymphocyte Count Coinfection - immunology Coinfection - parasitology Coinfection - virology Erythrocytes Female HIV HIV 1 HIV infections HIV Infections - complications HIV Infections - immunology HIV Infections - parasitology HIV/AIDS Human immunodeficiency virus Human immunodeficiency virus 1 Humans Immunoglobulin G - immunology Malaria Malaria, Falciparum - complications Malaria, Falciparum - immunology Malaria, Falciparum - virology Male Merozoites Middle Aged Parasitemia Parasites Plasmodium falciparum Plasmodium falciparum - immunology Young Adult |
| title | HIV-1 Infection and Antibodies to Plasmodium falciparum in Adults |
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