Pokemon proto-oncogene in oral cancer: potential role in the early phase of tumorigenesis

Objectives Oral squamous cell carcinoma (OSCC) represents about 90% of all oral neoplasms with a poor clinical prognosis. To improve survival of OSCC patients, it is fundamental to understand the basic molecular mechanisms characterizing oral carcinogenesis. Dysregulation of oncogenes and tumor supp...

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Veröffentlicht in:	Oral diseases 2015-05, Vol.21 (4), p.462-469
Hauptverfasser:	Sartini, D, Lo Muzio, L, Morganti, S, Pozzi, V, Di Ruscio, G, Rocchetti, R, Rubini, C, Santarelli, A, Emanuelli, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Biomarkers, Tumor - biosynthesis Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Carcinogenesis - genetics Carcinogenesis - metabolism Carcinogenesis - pathology Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology DNA-Binding Proteins - biosynthesis DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Down-Regulation Female Genes Head and Neck Neoplasms - genetics Head and Neck Neoplasms - metabolism Head and Neck Neoplasms - pathology histological grading Humans Male Medical prognosis Middle Aged Mouth Mucosa - pathology Mouth Neoplasms - genetics Mouth Neoplasms - metabolism Mouth Neoplasms - pathology Oral cancer Pokemon Proto-Oncogenes RNA, Messenger - biosynthesis RNA, Messenger - genetics Rodents Squamous Cell Carcinoma of Head and Neck Transcription Factors - biosynthesis Transcription Factors - genetics Transcription Factors - metabolism tumor size Tumorigenesis
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