Protective effects of naringenin on carbon tetrachloride-induced acute nephrotoxicity in mouse kidney

•Aim: Naringenin (NGN) protection against renal toxicity induced by CCl4 in mice.•The inhibition of antioxidant enzymes activity induced by CCl4 was prevented by NGN.•Pre-treatment with NGN decreased lipid peroxidation significantly.•Structural and ultrastructural alteration of kidney was prevented...

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Veröffentlicht in:	Chemico-biological interactions 2013-09, Vol.205 (2), p.138-147
Hauptverfasser:	Hermenean, Anca, Ardelean, Aurel, Stan, Miruna, Herman, Hildegard, Mihali, Ciprian-Valentin, Costache, Marieta, Dinischiotu, Anca
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Kidney Injury - metabolism Acute Kidney Injury - pathology Acute Kidney Injury - prevention & control Animals Antioxidant effects antioxidants Antioxidants - pharmacology biomarkers carbon carbon tetrachloride Carbon Tetrachloride - antagonists & inhibitors Carbon Tetrachloride - toxicity catalase CCl4 collagen epithelial cells Flavanones - pharmacology glutathione glutathione peroxidase Hepatitis A Virus Cellular Receptor 1 histopathology Kidney - drug effects Kidney - metabolism Kidney - pathology kidneys Lipid Peroxidation - drug effects lysosomes Male malondialdehyde Membrane Proteins - metabolism Mice Microscopy, Electron, Transmission mitochondria Naringenin necrosis Nephroprotection nephrotoxicity Oxidative stress pretreatment protective effect superoxide dismutase transforming growth factor beta 1 Transforming Growth Factor beta1 - metabolism
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