Protective effects of naringenin on carbon tetrachloride-induced acute nephrotoxicity in mouse kidney
•Aim: Naringenin (NGN) protection against renal toxicity induced by CCl4 in mice.•The inhibition of antioxidant enzymes activity induced by CCl4 was prevented by NGN.•Pre-treatment with NGN decreased lipid peroxidation significantly.•Structural and ultrastructural alteration of kidney was prevented...
Gespeichert in:
| Veröffentlicht in: | Chemico-biological interactions 2013-09, Vol.205 (2), p.138-147 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 147 |
|---|---|
| container_issue | 2 |
| container_start_page | 138 |
| container_title | Chemico-biological interactions |
| container_volume | 205 |
| creator | Hermenean, Anca Ardelean, Aurel Stan, Miruna Herman, Hildegard Mihali, Ciprian-Valentin Costache, Marieta Dinischiotu, Anca |
| description | •Aim: Naringenin (NGN) protection against renal toxicity induced by CCl4 in mice.•The inhibition of antioxidant enzymes activity induced by CCl4 was prevented by NGN.•Pre-treatment with NGN decreased lipid peroxidation significantly.•Structural and ultrastructural alteration of kidney was prevented by NGN treatment.•NGN showed antioxidant and renal protective effects against injury induced by CCl4.
The ability of naringenin (NGN) to protect the kidney against CCl4-induced renal toxicity in male Swiss mice was investigated. The flavonoid was given orally to mice for 7days and then on the 8th day, these were intraperitoneally injected with 10mmol/kg CCl4. When the toxicant was administrated alone, an increase of malondialdehyde (MDA) concentration was observed and a significant decrease in superoxide dismutase (SOD), catalase (CAT) glutathione-peroxidase (GPx) specific activities as well as glutathione (GSH) levels was detected after 24h. These were accompanied by glomerular and tubular degenerations, vascular congestion, necrosis and fatty changes. Marked collagen deposition and strong TGF-β1 expression were observed mainly in the mesangial cells of the glomeruli and tubulointerstitial areas. Ultrastructural investigations showed proximal and distal tubular epithelial cells alterations including numerous lysosomes and dense granular bodies, altered mitochondria, appearance of “myeloid bodies” and basal enfolding dilatation. Pre-treatment with NGN resulted in the return of biochemical markers to control values. Histopathological and electron-microscopic examinations confirmed the biochemical results. In conclusion, NGN showed antioxidant and renal protective effects against injuries induced by CCl4. |
| doi_str_mv | 10.1016/j.cbi.2013.06.016 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1687666471</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0009279713001567</els_id><sourcerecordid>1687666471</sourcerecordid><originalsourceid>FETCH-LOGICAL-c476t-15dfa78f416a511ebcfadd9d0b85f893e05569a3dfb29eda7e10010257502f63</originalsourceid><addsrcrecordid>eNp9kMFu1DAQhi0EotvCA3ABH7kkjJPYTsQJVUCRKoFEOVuOPW697NqLnVTs2zPVFo6cxh5988_oY-yVgFaAUO-2rZtj24HoW1AtdZ6wjRh112g9qqdsAwBT0-lJn7HzWrf0hW6A5-ys68dBTkpvGH4reUG3xHvkGAK9Ks-BJ1tiusUUE8-JO1tmKgsuxbq7XS7RYxOTXx16bt26IE94uKOk_Du6uBw5ze3zWpH_jD7h8QV7Fuyu4svHesFuPn28ubxqrr9-_nL54bpxg1ZLI6QPVo9hEMpKIXB2wXo_eZhHGcapR5BSTbb3Ye4m9FajABDQSS2hC6q_YG9PsYeSf61YF7OP1eFuZxPSNUaoUSulBi0IFSfUlVxrwWAOJe5tORoB5kGu2RqSax7kGlCGOjTz-jF-nffo_038tUnAmxMQbDb2tsRqfnynBEniafUwEPH-RCBZuI9YTHURE3mMhdwbn-N_DvgDnIWVPQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1687666471</pqid></control><display><type>article</type><title>Protective effects of naringenin on carbon tetrachloride-induced acute nephrotoxicity in mouse kidney</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Hermenean, Anca ; Ardelean, Aurel ; Stan, Miruna ; Herman, Hildegard ; Mihali, Ciprian-Valentin ; Costache, Marieta ; Dinischiotu, Anca</creator><creatorcontrib>Hermenean, Anca ; Ardelean, Aurel ; Stan, Miruna ; Herman, Hildegard ; Mihali, Ciprian-Valentin ; Costache, Marieta ; Dinischiotu, Anca</creatorcontrib><description>•Aim: Naringenin (NGN) protection against renal toxicity induced by CCl4 in mice.•The inhibition of antioxidant enzymes activity induced by CCl4 was prevented by NGN.•Pre-treatment with NGN decreased lipid peroxidation significantly.•Structural and ultrastructural alteration of kidney was prevented by NGN treatment.•NGN showed antioxidant and renal protective effects against injury induced by CCl4.
The ability of naringenin (NGN) to protect the kidney against CCl4-induced renal toxicity in male Swiss mice was investigated. The flavonoid was given orally to mice for 7days and then on the 8th day, these were intraperitoneally injected with 10mmol/kg CCl4. When the toxicant was administrated alone, an increase of malondialdehyde (MDA) concentration was observed and a significant decrease in superoxide dismutase (SOD), catalase (CAT) glutathione-peroxidase (GPx) specific activities as well as glutathione (GSH) levels was detected after 24h. These were accompanied by glomerular and tubular degenerations, vascular congestion, necrosis and fatty changes. Marked collagen deposition and strong TGF-β1 expression were observed mainly in the mesangial cells of the glomeruli and tubulointerstitial areas. Ultrastructural investigations showed proximal and distal tubular epithelial cells alterations including numerous lysosomes and dense granular bodies, altered mitochondria, appearance of “myeloid bodies” and basal enfolding dilatation. Pre-treatment with NGN resulted in the return of biochemical markers to control values. Histopathological and electron-microscopic examinations confirmed the biochemical results. In conclusion, NGN showed antioxidant and renal protective effects against injuries induced by CCl4.</description><identifier>ISSN: 0009-2797</identifier><identifier>EISSN: 1872-7786</identifier><identifier>DOI: 10.1016/j.cbi.2013.06.016</identifier><identifier>PMID: 23845967</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Acute Kidney Injury - metabolism ; Acute Kidney Injury - pathology ; Acute Kidney Injury - prevention & control ; Animals ; Antioxidant effects ; antioxidants ; Antioxidants - pharmacology ; biomarkers ; carbon ; carbon tetrachloride ; Carbon Tetrachloride - antagonists & inhibitors ; Carbon Tetrachloride - toxicity ; catalase ; CCl4 ; collagen ; epithelial cells ; Flavanones - pharmacology ; glutathione ; glutathione peroxidase ; Hepatitis A Virus Cellular Receptor 1 ; histopathology ; Kidney - drug effects ; Kidney - metabolism ; Kidney - pathology ; kidneys ; Lipid Peroxidation - drug effects ; lysosomes ; Male ; malondialdehyde ; Membrane Proteins - metabolism ; Mice ; Microscopy, Electron, Transmission ; mitochondria ; Naringenin ; necrosis ; Nephroprotection ; nephrotoxicity ; Oxidative stress ; pretreatment ; protective effect ; superoxide dismutase ; transforming growth factor beta 1 ; Transforming Growth Factor beta1 - metabolism</subject><ispartof>Chemico-biological interactions, 2013-09, Vol.205 (2), p.138-147</ispartof><rights>2013 Elsevier Ireland Ltd</rights><rights>Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c476t-15dfa78f416a511ebcfadd9d0b85f893e05569a3dfb29eda7e10010257502f63</citedby><cites>FETCH-LOGICAL-c476t-15dfa78f416a511ebcfadd9d0b85f893e05569a3dfb29eda7e10010257502f63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0009279713001567$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23845967$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hermenean, Anca</creatorcontrib><creatorcontrib>Ardelean, Aurel</creatorcontrib><creatorcontrib>Stan, Miruna</creatorcontrib><creatorcontrib>Herman, Hildegard</creatorcontrib><creatorcontrib>Mihali, Ciprian-Valentin</creatorcontrib><creatorcontrib>Costache, Marieta</creatorcontrib><creatorcontrib>Dinischiotu, Anca</creatorcontrib><title>Protective effects of naringenin on carbon tetrachloride-induced acute nephrotoxicity in mouse kidney</title><title>Chemico-biological interactions</title><addtitle>Chem Biol Interact</addtitle><description>•Aim: Naringenin (NGN) protection against renal toxicity induced by CCl4 in mice.•The inhibition of antioxidant enzymes activity induced by CCl4 was prevented by NGN.•Pre-treatment with NGN decreased lipid peroxidation significantly.•Structural and ultrastructural alteration of kidney was prevented by NGN treatment.•NGN showed antioxidant and renal protective effects against injury induced by CCl4.
The ability of naringenin (NGN) to protect the kidney against CCl4-induced renal toxicity in male Swiss mice was investigated. The flavonoid was given orally to mice for 7days and then on the 8th day, these were intraperitoneally injected with 10mmol/kg CCl4. When the toxicant was administrated alone, an increase of malondialdehyde (MDA) concentration was observed and a significant decrease in superoxide dismutase (SOD), catalase (CAT) glutathione-peroxidase (GPx) specific activities as well as glutathione (GSH) levels was detected after 24h. These were accompanied by glomerular and tubular degenerations, vascular congestion, necrosis and fatty changes. Marked collagen deposition and strong TGF-β1 expression were observed mainly in the mesangial cells of the glomeruli and tubulointerstitial areas. Ultrastructural investigations showed proximal and distal tubular epithelial cells alterations including numerous lysosomes and dense granular bodies, altered mitochondria, appearance of “myeloid bodies” and basal enfolding dilatation. Pre-treatment with NGN resulted in the return of biochemical markers to control values. Histopathological and electron-microscopic examinations confirmed the biochemical results. In conclusion, NGN showed antioxidant and renal protective effects against injuries induced by CCl4.</description><subject>Acute Kidney Injury - metabolism</subject><subject>Acute Kidney Injury - pathology</subject><subject>Acute Kidney Injury - prevention & control</subject><subject>Animals</subject><subject>Antioxidant effects</subject><subject>antioxidants</subject><subject>Antioxidants - pharmacology</subject><subject>biomarkers</subject><subject>carbon</subject><subject>carbon tetrachloride</subject><subject>Carbon Tetrachloride - antagonists & inhibitors</subject><subject>Carbon Tetrachloride - toxicity</subject><subject>catalase</subject><subject>CCl4</subject><subject>collagen</subject><subject>epithelial cells</subject><subject>Flavanones - pharmacology</subject><subject>glutathione</subject><subject>glutathione peroxidase</subject><subject>Hepatitis A Virus Cellular Receptor 1</subject><subject>histopathology</subject><subject>Kidney - drug effects</subject><subject>Kidney - metabolism</subject><subject>Kidney - pathology</subject><subject>kidneys</subject><subject>Lipid Peroxidation - drug effects</subject><subject>lysosomes</subject><subject>Male</subject><subject>malondialdehyde</subject><subject>Membrane Proteins - metabolism</subject><subject>Mice</subject><subject>Microscopy, Electron, Transmission</subject><subject>mitochondria</subject><subject>Naringenin</subject><subject>necrosis</subject><subject>Nephroprotection</subject><subject>nephrotoxicity</subject><subject>Oxidative stress</subject><subject>pretreatment</subject><subject>protective effect</subject><subject>superoxide dismutase</subject><subject>transforming growth factor beta 1</subject><subject>Transforming Growth Factor beta1 - metabolism</subject><issn>0009-2797</issn><issn>1872-7786</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFu1DAQhi0EotvCA3ABH7kkjJPYTsQJVUCRKoFEOVuOPW697NqLnVTs2zPVFo6cxh5988_oY-yVgFaAUO-2rZtj24HoW1AtdZ6wjRh112g9qqdsAwBT0-lJn7HzWrf0hW6A5-ys68dBTkpvGH4reUG3xHvkGAK9Ks-BJ1tiusUUE8-JO1tmKgsuxbq7XS7RYxOTXx16bt26IE94uKOk_Du6uBw5ze3zWpH_jD7h8QV7Fuyu4svHesFuPn28ubxqrr9-_nL54bpxg1ZLI6QPVo9hEMpKIXB2wXo_eZhHGcapR5BSTbb3Ye4m9FajABDQSS2hC6q_YG9PsYeSf61YF7OP1eFuZxPSNUaoUSulBi0IFSfUlVxrwWAOJe5tORoB5kGu2RqSax7kGlCGOjTz-jF-nffo_038tUnAmxMQbDb2tsRqfnynBEniafUwEPH-RCBZuI9YTHURE3mMhdwbn-N_DvgDnIWVPQ</recordid><startdate>20130925</startdate><enddate>20130925</enddate><creator>Hermenean, Anca</creator><creator>Ardelean, Aurel</creator><creator>Stan, Miruna</creator><creator>Herman, Hildegard</creator><creator>Mihali, Ciprian-Valentin</creator><creator>Costache, Marieta</creator><creator>Dinischiotu, Anca</creator><general>Elsevier Ireland Ltd</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20130925</creationdate><title>Protective effects of naringenin on carbon tetrachloride-induced acute nephrotoxicity in mouse kidney</title><author>Hermenean, Anca ; Ardelean, Aurel ; Stan, Miruna ; Herman, Hildegard ; Mihali, Ciprian-Valentin ; Costache, Marieta ; Dinischiotu, Anca</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c476t-15dfa78f416a511ebcfadd9d0b85f893e05569a3dfb29eda7e10010257502f63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Acute Kidney Injury - metabolism</topic><topic>Acute Kidney Injury - pathology</topic><topic>Acute Kidney Injury - prevention & control</topic><topic>Animals</topic><topic>Antioxidant effects</topic><topic>antioxidants</topic><topic>Antioxidants - pharmacology</topic><topic>biomarkers</topic><topic>carbon</topic><topic>carbon tetrachloride</topic><topic>Carbon Tetrachloride - antagonists & inhibitors</topic><topic>Carbon Tetrachloride - toxicity</topic><topic>catalase</topic><topic>CCl4</topic><topic>collagen</topic><topic>epithelial cells</topic><topic>Flavanones - pharmacology</topic><topic>glutathione</topic><topic>glutathione peroxidase</topic><topic>Hepatitis A Virus Cellular Receptor 1</topic><topic>histopathology</topic><topic>Kidney - drug effects</topic><topic>Kidney - metabolism</topic><topic>Kidney - pathology</topic><topic>kidneys</topic><topic>Lipid Peroxidation - drug effects</topic><topic>lysosomes</topic><topic>Male</topic><topic>malondialdehyde</topic><topic>Membrane Proteins - metabolism</topic><topic>Mice</topic><topic>Microscopy, Electron, Transmission</topic><topic>mitochondria</topic><topic>Naringenin</topic><topic>necrosis</topic><topic>Nephroprotection</topic><topic>nephrotoxicity</topic><topic>Oxidative stress</topic><topic>pretreatment</topic><topic>protective effect</topic><topic>superoxide dismutase</topic><topic>transforming growth factor beta 1</topic><topic>Transforming Growth Factor beta1 - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hermenean, Anca</creatorcontrib><creatorcontrib>Ardelean, Aurel</creatorcontrib><creatorcontrib>Stan, Miruna</creatorcontrib><creatorcontrib>Herman, Hildegard</creatorcontrib><creatorcontrib>Mihali, Ciprian-Valentin</creatorcontrib><creatorcontrib>Costache, Marieta</creatorcontrib><creatorcontrib>Dinischiotu, Anca</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Chemico-biological interactions</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hermenean, Anca</au><au>Ardelean, Aurel</au><au>Stan, Miruna</au><au>Herman, Hildegard</au><au>Mihali, Ciprian-Valentin</au><au>Costache, Marieta</au><au>Dinischiotu, Anca</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protective effects of naringenin on carbon tetrachloride-induced acute nephrotoxicity in mouse kidney</atitle><jtitle>Chemico-biological interactions</jtitle><addtitle>Chem Biol Interact</addtitle><date>2013-09-25</date><risdate>2013</risdate><volume>205</volume><issue>2</issue><spage>138</spage><epage>147</epage><pages>138-147</pages><issn>0009-2797</issn><eissn>1872-7786</eissn><abstract>•Aim: Naringenin (NGN) protection against renal toxicity induced by CCl4 in mice.•The inhibition of antioxidant enzymes activity induced by CCl4 was prevented by NGN.•Pre-treatment with NGN decreased lipid peroxidation significantly.•Structural and ultrastructural alteration of kidney was prevented by NGN treatment.•NGN showed antioxidant and renal protective effects against injury induced by CCl4.
The ability of naringenin (NGN) to protect the kidney against CCl4-induced renal toxicity in male Swiss mice was investigated. The flavonoid was given orally to mice for 7days and then on the 8th day, these were intraperitoneally injected with 10mmol/kg CCl4. When the toxicant was administrated alone, an increase of malondialdehyde (MDA) concentration was observed and a significant decrease in superoxide dismutase (SOD), catalase (CAT) glutathione-peroxidase (GPx) specific activities as well as glutathione (GSH) levels was detected after 24h. These were accompanied by glomerular and tubular degenerations, vascular congestion, necrosis and fatty changes. Marked collagen deposition and strong TGF-β1 expression were observed mainly in the mesangial cells of the glomeruli and tubulointerstitial areas. Ultrastructural investigations showed proximal and distal tubular epithelial cells alterations including numerous lysosomes and dense granular bodies, altered mitochondria, appearance of “myeloid bodies” and basal enfolding dilatation. Pre-treatment with NGN resulted in the return of biochemical markers to control values. Histopathological and electron-microscopic examinations confirmed the biochemical results. In conclusion, NGN showed antioxidant and renal protective effects against injuries induced by CCl4.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>23845967</pmid><doi>10.1016/j.cbi.2013.06.016</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0009-2797 |
| ispartof | Chemico-biological interactions, 2013-09, Vol.205 (2), p.138-147 |
| issn | 0009-2797 1872-7786 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1687666471 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Acute Kidney Injury - metabolism Acute Kidney Injury - pathology Acute Kidney Injury - prevention & control Animals Antioxidant effects antioxidants Antioxidants - pharmacology biomarkers carbon carbon tetrachloride Carbon Tetrachloride - antagonists & inhibitors Carbon Tetrachloride - toxicity catalase CCl4 collagen epithelial cells Flavanones - pharmacology glutathione glutathione peroxidase Hepatitis A Virus Cellular Receptor 1 histopathology Kidney - drug effects Kidney - metabolism Kidney - pathology kidneys Lipid Peroxidation - drug effects lysosomes Male malondialdehyde Membrane Proteins - metabolism Mice Microscopy, Electron, Transmission mitochondria Naringenin necrosis Nephroprotection nephrotoxicity Oxidative stress pretreatment protective effect superoxide dismutase transforming growth factor beta 1 Transforming Growth Factor beta1 - metabolism |
| title | Protective effects of naringenin on carbon tetrachloride-induced acute nephrotoxicity in mouse kidney |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T04%3A19%3A23IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Protective%20effects%20of%20naringenin%20on%20carbon%20tetrachloride-induced%20acute%20nephrotoxicity%20in%20mouse%20kidney&rft.jtitle=Chemico-biological%20interactions&rft.au=Hermenean,%20Anca&rft.date=2013-09-25&rft.volume=205&rft.issue=2&rft.spage=138&rft.epage=147&rft.pages=138-147&rft.issn=0009-2797&rft.eissn=1872-7786&rft_id=info:doi/10.1016/j.cbi.2013.06.016&rft_dat=%3Cproquest_cross%3E1687666471%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1687666471&rft_id=info:pmid/23845967&rft_els_id=S0009279713001567&rfr_iscdi=true |