Essential role of Dkk3 for head formation by inhibiting Wnt/β-catenin and Nodal/Vg1 signaling pathways in the basal chordate amphioxus

SUMMARY To dissect the molecular mechanism of head specification in the basal chordate amphioxus, we investigated the function of Dkk3, a secreted protein in the Dickkopf family, which is expressed anteriorly in early embryos. Amphioxus Dkk3 has three domains characteristic of Dkk3 proteins—an N‐ter...

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Veröffentlicht in:	Evolution & development 2012-07, Vol.14 (4), p.338-350
Hauptverfasser:	Onai, Takayuki, Akira Takai, Setiamarga, Davin H. E., Holland, Linda Z.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals beta Catenin - genetics beta Catenin - metabolism Body Patterning - drug effects Body Patterning - physiology Branchiostoma lanceolatum Chordata Chordata, Nonvertebrate - embryology Chordata, Nonvertebrate - genetics Evolution, Molecular Head Morpholinos - genetics Morpholinos - pharmacology Nodal Protein - genetics Nodal Protein - metabolism Transforming Growth Factor beta - metabolism Wnt Proteins - genetics Wnt Proteins - metabolism Wnt Signaling Pathway - drug effects Wnt Signaling Pathway - physiology Xenopus
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