Addition of UVA-absorber butyl methoxy dibenzoylmethane to topical ketoprofen formulation reduces ketoprofen-photoallergic reaction

► We examine the inhibitory effect of UVA filters for ketoprofen photocontact dermatitis. ► Butyl methoxy dibenzoylmethane is the most effective UVA filter. ► Patch and gel containing the UVA filter retain the pharmacokinetic performance. ► The UVA filter in both topical formulations suppresses keto...

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Veröffentlicht in:	Journal of photochemistry and photobiology. B, Biology Biology, 2012-08, Vol.113, p.56-62
Hauptverfasser:	Atarashi, Kenji, Takano, Masashi, Kato, Shunsuke, Kuma, Hidekazu, Nakanishi, Masaru, Tokura, Yoshiki
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Topical adverse effects Alkanes - chemistry Animals anti-inflammatory activity benzophenone Butyl methoxy dibenzoylmethane Chalcones - chemistry Chemistry, Pharmaceutical cross reaction dermatitis Dermatitis, Phototoxic - etiology Dermatitis, Phototoxic - prevention & control ears Female gels Guinea Pigs irradiation Ketoprofen Ketoprofen - adverse effects Ketoprofen - chemistry local lymph node assay lymph nodes Mice Mice, Inbred BALB C Photoallergy photobiology photochemistry Photocontact dermatitis photosensitivity Plaster Propiophenones Radiation-Protective Agents - chemistry topical application Ultraviolet Rays UVA
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