Mouse gastrocnemius muscle regeneration after mechanical or cardiotoxin injury
The goal of our study was to compare the skeletal muscle regeneration induced by two types of injury: either crushing, that causes muscle degeneration as a result of mechanical devastation of myofibers, or the injection of a cardiotoxin that is a myotoxic agent causing myolysis of myofibers leading...
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| Veröffentlicht in: | Folia histochemica et cytobiologica 2012-01, Vol.50 (1), p.144-153 |
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| container_title | Folia histochemica et cytobiologica |
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| creator | Czerwinska, Areta M Streminska, Wladyslawa Ciemerych, Maria A Grabowska, Iwona |
| description | The goal of our study was to compare the skeletal muscle regeneration induced by two types of injury: either crushing, that causes muscle degeneration as a result of mechanical devastation of myofibers, or the injection of a cardiotoxin that is a myotoxic agent causing myolysis of myofibers leading to muscle degeneration. Regenerating muscles were analyzed at selected intervals, until the 14th day following the injury. We analyzed their weight and morphology. We also studied the expression of different myosin heavy chain isoforms as a molecular marker of the regeneration progress. Histological analysis revealed that inflammatory response and myotube formation in crushed muscles was delayed compared to cardiotoxin-injected ones. Moreover, the expression of myosin heavy chain isoforms was observed earlier in cardiotoxin-injured versus crushed muscles. We conclude that the dynamics of skeletal muscle regeneration depends on the method of injury. |
| doi_str_mv | 10.5603/FHC.2012.0021 |
| format | Article |
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Regenerating muscles were analyzed at selected intervals, until the 14th day following the injury. We analyzed their weight and morphology. We also studied the expression of different myosin heavy chain isoforms as a molecular marker of the regeneration progress. Histological analysis revealed that inflammatory response and myotube formation in crushed muscles was delayed compared to cardiotoxin-injected ones. Moreover, the expression of myosin heavy chain isoforms was observed earlier in cardiotoxin-injured versus crushed muscles. We conclude that the dynamics of skeletal muscle regeneration depends on the method of injury.</description><identifier>ISSN: 0239-8508</identifier><identifier>EISSN: 1897-5631</identifier><identifier>DOI: 10.5603/FHC.2012.0021</identifier><language>eng</language><publisher>Bialystok: Wydawnictwo Via Medica</publisher><subject>Chains ; Crushing ; Degeneration ; Gastrocnemius muscle ; Inflammation ; Inflammatory response ; Injuries ; Injury analysis ; Isoforms ; Muscles ; Myosin ; Myotubes ; Regeneration ; Skeletal muscle</subject><ispartof>Folia histochemica et cytobiologica, 2012-01, Vol.50 (1), p.144-153</ispartof><rights>Copyright Folia Histochemica et Cytobiologica 2012</rights><rights>2012. This work is published under https://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c326t-53e045336551078ad0cae6c66fce3ba8c05099b2487d7126a54d2e6ad1f440fc3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,864,27924,27925</link.rule.ids></links><search><creatorcontrib>Czerwinska, Areta M</creatorcontrib><creatorcontrib>Streminska, Wladyslawa</creatorcontrib><creatorcontrib>Ciemerych, Maria A</creatorcontrib><creatorcontrib>Grabowska, Iwona</creatorcontrib><title>Mouse gastrocnemius muscle regeneration after mechanical or cardiotoxin injury</title><title>Folia histochemica et cytobiologica</title><description>The goal of our study was to compare the skeletal muscle regeneration induced by two types of injury: either crushing, that causes muscle degeneration as a result of mechanical devastation of myofibers, or the injection of a cardiotoxin that is a myotoxic agent causing myolysis of myofibers leading to muscle degeneration. Regenerating muscles were analyzed at selected intervals, until the 14th day following the injury. We analyzed their weight and morphology. We also studied the expression of different myosin heavy chain isoforms as a molecular marker of the regeneration progress. Histological analysis revealed that inflammatory response and myotube formation in crushed muscles was delayed compared to cardiotoxin-injected ones. Moreover, the expression of myosin heavy chain isoforms was observed earlier in cardiotoxin-injured versus crushed muscles. We conclude that the dynamics of skeletal muscle regeneration depends on the method of injury.</description><subject>Chains</subject><subject>Crushing</subject><subject>Degeneration</subject><subject>Gastrocnemius muscle</subject><subject>Inflammation</subject><subject>Inflammatory response</subject><subject>Injuries</subject><subject>Injury analysis</subject><subject>Isoforms</subject><subject>Muscles</subject><subject>Myosin</subject><subject>Myotubes</subject><subject>Regeneration</subject><subject>Skeletal 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| source | DOAJ Directory of Open Access Journals; EZB Electronic Journals Library |
| subjects | Chains Crushing Degeneration Gastrocnemius muscle Inflammation Inflammatory response Injuries Injury analysis Isoforms Muscles Myosin Myotubes Regeneration Skeletal muscle |
| title | Mouse gastrocnemius muscle regeneration after mechanical or cardiotoxin injury |
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