Effects of Zinc on Interleukins and Antioxidant Enzyme Values in Psoriasis-Induced Mice

The effects of zinc chloride (ZnCl₂), disodium zinc ethylenediamine tetraacetate (Zn-EDTA), and zinc gluconate (Zn-GLU) on the antioxidant enzyme activities and levels of interleukins (ILs) in psoriasis-induced mice were studied. One hundred twenty female mice were randomly divided into six groups w...

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Veröffentlicht in:	Biological trace element research 2013-12, Vol.155 (3), p.411-415
Hauptverfasser:	Yin, L. L, Zhang, Y, Guo, D. M, An, K, Yin, M. S, Cui, X
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants Antioxidants - metabolism Biochemistry Biomedical and Life Sciences Biotechnology blood serum catalase Catalase - metabolism Dietary supplements diethylstilbestrol Enzymatic activity enzyme activity Enzymes epithelium Female glutathione peroxidase Glutathione Peroxidase - metabolism interleukin-2 Interleukin-2 - blood Interleukins - metabolism Life Sciences Lipid Peroxidation - drug effects liver Liver - drug effects Liver - metabolism malondialdehyde Malondialdehyde - metabolism methotrexate Mice mitosis Nutrition Oncology Oxidative stress Oxidative Stress - drug effects Psoriasis Psoriasis - blood Psoriasis - drug therapy Psoriasis - metabolism Skin diseases superoxide dismutase Superoxide Dismutase - metabolism Zinc Zinc - therapeutic use
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Zusammenfassung:	The effects of zinc chloride (ZnCl₂), disodium zinc ethylenediamine tetraacetate (Zn-EDTA), and zinc gluconate (Zn-GLU) on the antioxidant enzyme activities and levels of interleukins (ILs) in psoriasis-induced mice were studied. One hundred twenty female mice were randomly divided into six groups with 20 mice in each group: the control, positive control (PC), methotrexate (MTX), ZnCl₂, Zn-EDTA, and Zn-GLU groups. All animals except the control group were given diethylstilbestrol for three consecutive days. After successfully inducing psoriasis, the control and PC groups were given normal saline (i.g.) daily while the remaining groups were given MTX, ZnCl₂, Zn-EDTA, and Zn-GLU, respectively. The results revealed that the zinc supplementation could significantly (p
ISSN:	0163-4984 1559-0720
DOI:	10.1007/s12011-013-9799-0