Water-restraint stress enhances methamphetamine-induced cardiotoxicity
Methamphetamine (MAP) and stress both cause a variety of cardiovascular problems. Stress also increases stimulant drug-seeking or drug-taking behavior by both humans and animals. In addition to the physiological effects on circulation, metabolism, and excretion, stress affects subject's respons...
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| Veröffentlicht in: | Chemico-biological interactions 2011-03, Vol.190 (1), p.54-61 |
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| creator | Tomita, Masafumi Katsuyama, Hironobu Watanabe, Yoko Hidaka, Kazuo Yoshitome, Kei Miyaishi, Satoru Ishikawa, Takaki Shinone, Kotaro Nata, Masayuki |
| description | Methamphetamine (MAP) and stress both cause a variety of cardiovascular problems. Stress also increases stimulant drug-seeking or drug-taking behavior by both humans and animals. In addition to the physiological effects on circulation, metabolism, and excretion, stress affects subject's responses to stimulant drugs such as MAP. However, the mechanisms underlying the drug–stress interactions remain unknown. In the present study, we assessed the effects of stress on myocardial responses to MAP in mice. Mice were injected with MAP (30mg/kg) immediately before exposure to water-restraint stress (WRS), which has often been used as a stressor in animal experiments. The combination of MAP with WRS produced a significant increase (p |
| doi_str_mv | 10.1016/j.cbi.2011.01.025 |
| format | Article |
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Stress also increases stimulant drug-seeking or drug-taking behavior by both humans and animals. In addition to the physiological effects on circulation, metabolism, and excretion, stress affects subject's responses to stimulant drugs such as MAP. However, the mechanisms underlying the drug–stress interactions remain unknown. In the present study, we assessed the effects of stress on myocardial responses to MAP in mice. Mice were injected with MAP (30mg/kg) immediately before exposure to water-restraint stress (WRS), which has often been used as a stressor in animal experiments. The combination of MAP with WRS produced a significant increase (p<0.01) in the leakage of proteins specific to myocardial damage and the levels of cytokines IL-6, TNF-α, and IL-10. The histological findings indicated the possibility that a combination of MAP with WRS induced cardiac myocytolysis. We also examined the expression of heat shock proteins (Hsps), which have cardioprotective effects. Administration of MAP alone significantly stimulated the RNA expressions of Hsp32, 60, 70, and 90 and the protein Hsp70 in cardiac muscles, whereas the expressions due to WRS or MAP plus WRS were not increased. These results reveal the fact that exposure to WRS depresses the induction of Hsps, in particular Hsp70, due to MAP injection, following to enhance MAP-induced myocardial damage. We believe that interactions between MAP and severe stress, including environmental temperature, affect the induction of Hsps, following to susceptibility of hosts to cardiotoxicity due to the stimulant drug.</description><identifier>ISSN: 0009-2797</identifier><identifier>EISSN: 1872-7786</identifier><identifier>DOI: 10.1016/j.cbi.2011.01.025</identifier><identifier>PMID: 21276779</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>ambient temperature ; animal experimentation ; Animals ; cardioprotective effect ; Cardiotoxicity ; Central Nervous System Stimulants - toxicity ; Chaperonin 60 - genetics ; Chaperonin 60 - metabolism ; drugs ; excretion ; Fatty Acid-Binding Proteins - metabolism ; Heart - drug effects ; Heat shock protein ; heat shock proteins ; hosts ; HSP70 Heat-Shock Proteins - genetics ; HSP70 Heat-Shock Proteins - metabolism ; HSP90 Heat-Shock Proteins - genetics ; HSP90 Heat-Shock Proteins - metabolism ; humans ; Immersion ; interleukin-10 ; Interleukin-10 - metabolism ; interleukin-6 ; Interleukin-6 - metabolism ; metabolism ; Methamphetamine ; Methamphetamine - toxicity ; Mice ; muscles ; Myocardia ; Myocardium - metabolism ; Myocardium - pathology ; RNA ; Stress, Physiological ; Temperature ; Tumor Necrosis Factor-alpha - metabolism ; Water-restraint stress</subject><ispartof>Chemico-biological interactions, 2011-03, Vol.190 (1), p.54-61</ispartof><rights>2011 Elsevier Ireland Ltd</rights><rights>2011 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c409t-9e690eb2298c4526059ce08e16e754cb651a7c64cc8130ff91d47dac55f4397e3</citedby><cites>FETCH-LOGICAL-c409t-9e690eb2298c4526059ce08e16e754cb651a7c64cc8130ff91d47dac55f4397e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0009279711000494$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21276779$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tomita, Masafumi</creatorcontrib><creatorcontrib>Katsuyama, Hironobu</creatorcontrib><creatorcontrib>Watanabe, Yoko</creatorcontrib><creatorcontrib>Hidaka, Kazuo</creatorcontrib><creatorcontrib>Yoshitome, Kei</creatorcontrib><creatorcontrib>Miyaishi, Satoru</creatorcontrib><creatorcontrib>Ishikawa, Takaki</creatorcontrib><creatorcontrib>Shinone, Kotaro</creatorcontrib><creatorcontrib>Nata, Masayuki</creatorcontrib><title>Water-restraint stress enhances methamphetamine-induced cardiotoxicity</title><title>Chemico-biological interactions</title><addtitle>Chem Biol Interact</addtitle><description>Methamphetamine (MAP) and stress both cause a variety of cardiovascular problems. Stress also increases stimulant drug-seeking or drug-taking behavior by both humans and animals. In addition to the physiological effects on circulation, metabolism, and excretion, stress affects subject's responses to stimulant drugs such as MAP. However, the mechanisms underlying the drug–stress interactions remain unknown. In the present study, we assessed the effects of stress on myocardial responses to MAP in mice. Mice were injected with MAP (30mg/kg) immediately before exposure to water-restraint stress (WRS), which has often been used as a stressor in animal experiments. The combination of MAP with WRS produced a significant increase (p<0.01) in the leakage of proteins specific to myocardial damage and the levels of cytokines IL-6, TNF-α, and IL-10. The histological findings indicated the possibility that a combination of MAP with WRS induced cardiac myocytolysis. We also examined the expression of heat shock proteins (Hsps), which have cardioprotective effects. Administration of MAP alone significantly stimulated the RNA expressions of Hsp32, 60, 70, and 90 and the protein Hsp70 in cardiac muscles, whereas the expressions due to WRS or MAP plus WRS were not increased. These results reveal the fact that exposure to WRS depresses the induction of Hsps, in particular Hsp70, due to MAP injection, following to enhance MAP-induced myocardial damage. We believe that interactions between MAP and severe stress, including environmental temperature, affect the induction of Hsps, following to susceptibility of hosts to cardiotoxicity due to the stimulant drug.</description><subject>ambient temperature</subject><subject>animal experimentation</subject><subject>Animals</subject><subject>cardioprotective effect</subject><subject>Cardiotoxicity</subject><subject>Central Nervous System Stimulants - toxicity</subject><subject>Chaperonin 60 - genetics</subject><subject>Chaperonin 60 - metabolism</subject><subject>drugs</subject><subject>excretion</subject><subject>Fatty Acid-Binding Proteins - metabolism</subject><subject>Heart - drug effects</subject><subject>Heat shock protein</subject><subject>heat shock proteins</subject><subject>hosts</subject><subject>HSP70 Heat-Shock Proteins - genetics</subject><subject>HSP70 Heat-Shock Proteins - metabolism</subject><subject>HSP90 Heat-Shock Proteins - genetics</subject><subject>HSP90 Heat-Shock Proteins - metabolism</subject><subject>humans</subject><subject>Immersion</subject><subject>interleukin-10</subject><subject>Interleukin-10 - metabolism</subject><subject>interleukin-6</subject><subject>Interleukin-6 - metabolism</subject><subject>metabolism</subject><subject>Methamphetamine</subject><subject>Methamphetamine - toxicity</subject><subject>Mice</subject><subject>muscles</subject><subject>Myocardia</subject><subject>Myocardium - metabolism</subject><subject>Myocardium - pathology</subject><subject>RNA</subject><subject>Stress, Physiological</subject><subject>Temperature</subject><subject>Tumor Necrosis Factor-alpha - metabolism</subject><subject>Water-restraint stress</subject><issn>0009-2797</issn><issn>1872-7786</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LAzEQhoMoWqs_wIv26GXrJN0kGzxJ8QsEDyoeQzo7a1O6uzVJRf-9KVWPwsAw8Lwvw8PYCYcxB64uFmOc-bEAzseQR8gdNuCVFoXWldplAwAwhdBGH7DDGBf5BFHCPjsQXGiltRmwm1eXKBSBYgrOd2mUN8U4om7uOqQ4ainNXbuaU3Kt76jwXb1GqkfoQu371H969OnriO01bhnp-GcP2cvN9fP0rnh4vL2fXj0UWIJJhSFlgGZCmApLKRRIgwQVcUValjhTkjuNqkSs-ASaxvC61LVDKZtyYjRNhux827sK_fs6P21bH5GWS9dRv46Wq0orVQLXGeVbFEMfY6DGroJvXfiyHOxGn13YrM9u9FnII2TOnP7Ur2ct1X-JX18ZONsCjeutews-2pen3CCzWlVNhMrE5ZagrOHDU7ARPWWVtQ-Eyda9_-eBb1DEiZY</recordid><startdate>20110315</startdate><enddate>20110315</enddate><creator>Tomita, Masafumi</creator><creator>Katsuyama, Hironobu</creator><creator>Watanabe, Yoko</creator><creator>Hidaka, Kazuo</creator><creator>Yoshitome, Kei</creator><creator>Miyaishi, Satoru</creator><creator>Ishikawa, Takaki</creator><creator>Shinone, Kotaro</creator><creator>Nata, Masayuki</creator><general>Elsevier Ireland Ltd</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20110315</creationdate><title>Water-restraint stress enhances methamphetamine-induced cardiotoxicity</title><author>Tomita, Masafumi ; Katsuyama, Hironobu ; Watanabe, Yoko ; Hidaka, Kazuo ; Yoshitome, Kei ; Miyaishi, Satoru ; Ishikawa, Takaki ; Shinone, Kotaro ; Nata, Masayuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c409t-9e690eb2298c4526059ce08e16e754cb651a7c64cc8130ff91d47dac55f4397e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>ambient temperature</topic><topic>animal experimentation</topic><topic>Animals</topic><topic>cardioprotective effect</topic><topic>Cardiotoxicity</topic><topic>Central Nervous System Stimulants - toxicity</topic><topic>Chaperonin 60 - genetics</topic><topic>Chaperonin 60 - metabolism</topic><topic>drugs</topic><topic>excretion</topic><topic>Fatty Acid-Binding Proteins - metabolism</topic><topic>Heart - drug effects</topic><topic>Heat shock protein</topic><topic>heat shock proteins</topic><topic>hosts</topic><topic>HSP70 Heat-Shock Proteins - genetics</topic><topic>HSP70 Heat-Shock Proteins - metabolism</topic><topic>HSP90 Heat-Shock Proteins - genetics</topic><topic>HSP90 Heat-Shock Proteins - metabolism</topic><topic>humans</topic><topic>Immersion</topic><topic>interleukin-10</topic><topic>Interleukin-10 - metabolism</topic><topic>interleukin-6</topic><topic>Interleukin-6 - metabolism</topic><topic>metabolism</topic><topic>Methamphetamine</topic><topic>Methamphetamine - toxicity</topic><topic>Mice</topic><topic>muscles</topic><topic>Myocardia</topic><topic>Myocardium - metabolism</topic><topic>Myocardium - pathology</topic><topic>RNA</topic><topic>Stress, Physiological</topic><topic>Temperature</topic><topic>Tumor Necrosis Factor-alpha - metabolism</topic><topic>Water-restraint stress</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tomita, Masafumi</creatorcontrib><creatorcontrib>Katsuyama, Hironobu</creatorcontrib><creatorcontrib>Watanabe, Yoko</creatorcontrib><creatorcontrib>Hidaka, Kazuo</creatorcontrib><creatorcontrib>Yoshitome, Kei</creatorcontrib><creatorcontrib>Miyaishi, Satoru</creatorcontrib><creatorcontrib>Ishikawa, Takaki</creatorcontrib><creatorcontrib>Shinone, Kotaro</creatorcontrib><creatorcontrib>Nata, Masayuki</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Chemico-biological interactions</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tomita, Masafumi</au><au>Katsuyama, Hironobu</au><au>Watanabe, Yoko</au><au>Hidaka, Kazuo</au><au>Yoshitome, Kei</au><au>Miyaishi, Satoru</au><au>Ishikawa, Takaki</au><au>Shinone, Kotaro</au><au>Nata, Masayuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Water-restraint stress enhances methamphetamine-induced cardiotoxicity</atitle><jtitle>Chemico-biological interactions</jtitle><addtitle>Chem Biol Interact</addtitle><date>2011-03-15</date><risdate>2011</risdate><volume>190</volume><issue>1</issue><spage>54</spage><epage>61</epage><pages>54-61</pages><issn>0009-2797</issn><eissn>1872-7786</eissn><abstract>Methamphetamine (MAP) and stress both cause a variety of cardiovascular problems. Stress also increases stimulant drug-seeking or drug-taking behavior by both humans and animals. In addition to the physiological effects on circulation, metabolism, and excretion, stress affects subject's responses to stimulant drugs such as MAP. However, the mechanisms underlying the drug–stress interactions remain unknown. In the present study, we assessed the effects of stress on myocardial responses to MAP in mice. Mice were injected with MAP (30mg/kg) immediately before exposure to water-restraint stress (WRS), which has often been used as a stressor in animal experiments. The combination of MAP with WRS produced a significant increase (p<0.01) in the leakage of proteins specific to myocardial damage and the levels of cytokines IL-6, TNF-α, and IL-10. The histological findings indicated the possibility that a combination of MAP with WRS induced cardiac myocytolysis. We also examined the expression of heat shock proteins (Hsps), which have cardioprotective effects. Administration of MAP alone significantly stimulated the RNA expressions of Hsp32, 60, 70, and 90 and the protein Hsp70 in cardiac muscles, whereas the expressions due to WRS or MAP plus WRS were not increased. These results reveal the fact that exposure to WRS depresses the induction of Hsps, in particular Hsp70, due to MAP injection, following to enhance MAP-induced myocardial damage. We believe that interactions between MAP and severe stress, including environmental temperature, affect the induction of Hsps, following to susceptibility of hosts to cardiotoxicity due to the stimulant drug.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>21276779</pmid><doi>10.1016/j.cbi.2011.01.025</doi><tpages>8</tpages></addata></record> |
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| subjects | ambient temperature animal experimentation Animals cardioprotective effect Cardiotoxicity Central Nervous System Stimulants - toxicity Chaperonin 60 - genetics Chaperonin 60 - metabolism drugs excretion Fatty Acid-Binding Proteins - metabolism Heart - drug effects Heat shock protein heat shock proteins hosts HSP70 Heat-Shock Proteins - genetics HSP70 Heat-Shock Proteins - metabolism HSP90 Heat-Shock Proteins - genetics HSP90 Heat-Shock Proteins - metabolism humans Immersion interleukin-10 Interleukin-10 - metabolism interleukin-6 Interleukin-6 - metabolism metabolism Methamphetamine Methamphetamine - toxicity Mice muscles Myocardia Myocardium - metabolism Myocardium - pathology RNA Stress, Physiological Temperature Tumor Necrosis Factor-alpha - metabolism Water-restraint stress |
| title | Water-restraint stress enhances methamphetamine-induced cardiotoxicity |
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