Genetic Mechanisms in Interval Colon Cancers

Background and Aim The factors underlying the development of interval colon cancers are not well defined and are likely heterogeneous. We sought to determine whether there are distinct molecular properties associated with interval colon cancers. Methods Colon cancers diagnosed within 5 years of a co...

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Veröffentlicht in:	Digestive diseases and sciences 2014-09, Vol.59 (9), p.2255-2263
Hauptverfasser:	Richter, James M., Pino, Maria Simona, Austin, Thomas R., Campbell, Emily, Szymonifka, Jackie, Russo, Andrea L., Hong, Theodore S., Borger, Darrell, Iafrate, A. John, Chung, Daniel C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - analysis Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Adenocarcinoma - chemistry Adenocarcinoma - genetics Adenocarcinoma - pathology Adenoma - diagnosis Adenosine Triphosphatases - analysis Adult Aged Aged, 80 and over Analysis Biochemistry Cancer Cecal Neoplasms - chemistry Cecal Neoplasms - genetics Cecal Neoplasms - pathology Class I Phosphatidylinositol 3-Kinases Colon cancer Colon, Ascending - pathology Colonic Neoplasms - chemistry Colonic Neoplasms - genetics Colonic Neoplasms - pathology Colonic Polyps - diagnosis Colonoscopy Colorectal Neoplasms, Hereditary Nonpolyposis - genetics Development and progression DNA Methylation DNA Mismatch Repair DNA Repair Enzymes - analysis DNA-Binding Proteins - analysis Ethylenediaminetetraacetic acid Female Gastroenterology Genetic aspects Genotype GTP Phosphohydrolases - genetics Hepatology Humans Immunohistochemistry Male Medicine Medicine & Public Health Membrane Proteins - genetics Methylation Microsatellite Instability Middle Aged Mismatch Repair Endonuclease PMS2 MutL Protein Homolog 1 MutS Homolog 2 Protein - analysis Nuclear Proteins - analysis Nuclear Proteins - genetics Nuclear Proteins - metabolism Oncology Original Article Phosphatidylinositol 3-Kinases - genetics Promoter Regions, Genetic Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins B-raf - genetics Proto-Oncogene Proteins p21(ras) ras Proteins - genetics Time Factors Transplant Surgery
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