Effect of chronic consumption of Piliostigma thonningii on activities of alanine aminotransferase and aspartate aminotransferase in serum and liver in Rattus novergicus
The effect of chronic consumption of Piliostigma thonningii on the activities of Aspartate Aminotransferases (AST) and Alanine Aminotransferases (ALT) on serum and liver of Rattus novergicus was investigated in this research. The aim of this study was to check the possible effect of chronic consumpt...
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| Veröffentlicht in: | Pakistan journal of biological sciences 2013-12, Vol.16 (24), p.2062-2065 |
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| creator | Awhin, E P Jeroh, E Anigboro, A A Rachael, Nwaoroko |
| description | The effect of chronic consumption of Piliostigma thonningii on the activities of Aspartate Aminotransferases (AST) and Alanine Aminotransferases (ALT) on serum and liver of Rattus novergicus was investigated in this research. The aim of this study was to check the possible effect of chronic consumption of Piliostigma thonningii on the activities of the liver biomarkers (ALT and AST) in Rattus novergicus. The results from this study revealed that the activities of aspartate aminotransferase (AST) in serum, showed a significant increase (34.20 +/- 12.9*) at (p < 0.05) upon chronic consumption of ethanolic extract of P. thonningii when compared with that of the control B (18.02 +/- 1.54). The result also showed that the liver AST was significantly increased (32.75 +/- 5.89*) when compared to that of the control B (17.01 +/- 1.81) at (p < 0.05). The results from the study also revealed that there was a significant increase in the activity of alanine aminotransferase in the liver (17.01 +/- 5.86*) when compared with that of the control B (5.1 +/- 1.11) at (p < 0.05). There was a corresponding increase in serum activity of the enzyme ALT (13.65 +/- 3.79*) when compared with that of the control B (9.4 +/- 1.98) at (p < 0.05). The results from this research has shown that chronic consumption of P. thonningii may cause liver injury thereby, increasing the liver enzyme activity (17.01 +/- 5.86*). This was shown in the corresponding increase in the serum level. Excessive consumption of the extract of P. thonningii has a toxicity potential on the liver and possibly other organs and tissues. |
| doi_str_mv | 10.3923/pjbs.2013.2062.2065 |
| format | Article |
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The aim of this study was to check the possible effect of chronic consumption of Piliostigma thonningii on the activities of the liver biomarkers (ALT and AST) in Rattus novergicus. The results from this study revealed that the activities of aspartate aminotransferase (AST) in serum, showed a significant increase (34.20 +/- 12.9*) at (p < 0.05) upon chronic consumption of ethanolic extract of P. thonningii when compared with that of the control B (18.02 +/- 1.54). The result also showed that the liver AST was significantly increased (32.75 +/- 5.89*) when compared to that of the control B (17.01 +/- 1.81) at (p < 0.05). The results from the study also revealed that there was a significant increase in the activity of alanine aminotransferase in the liver (17.01 +/- 5.86*) when compared with that of the control B (5.1 +/- 1.11) at (p < 0.05). There was a corresponding increase in serum activity of the enzyme ALT (13.65 +/- 3.79*) when compared with that of the control B (9.4 +/- 1.98) at (p < 0.05). The results from this research has shown that chronic consumption of P. thonningii may cause liver injury thereby, increasing the liver enzyme activity (17.01 +/- 5.86*). This was shown in the corresponding increase in the serum level. Excessive consumption of the extract of P. thonningii has a toxicity potential on the liver and possibly other organs and tissues.</description><identifier>ISSN: 1028-8880</identifier><identifier>EISSN: 1812-5735</identifier><identifier>DOI: 10.3923/pjbs.2013.2062.2065</identifier><identifier>PMID: 24517031</identifier><language>eng</language><publisher>Pakistan</publisher><subject>Alanine Transaminase - blood ; Animals ; Aspartate Aminotransferases - blood ; Biomarkers - blood ; Chemical and Drug Induced Liver Injury - blood ; Chemical and Drug Induced Liver Injury - enzymology ; Chemical and Drug Induced Liver Injury - etiology ; Ethanol - chemistry ; Fabaceae ; Female ; Liver - drug effects ; Liver - enzymology ; Male ; Phytotherapy ; Plant Bark ; Plant Extracts - administration & dosage ; Plant Extracts - toxicity ; Plants, Medicinal ; Rats ; Rats, Wistar ; Rattus ; Solvents - chemistry ; Time Factors ; Up-Regulation</subject><ispartof>Pakistan journal of biological sciences, 2013-12, Vol.16 (24), p.2062-2065</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c253t-b03f98cda8be1dcf0d35ea3734a06f8691c5b3d3fe577e1f1c51c380a903c0983</citedby><cites>FETCH-LOGICAL-c253t-b03f98cda8be1dcf0d35ea3734a06f8691c5b3d3fe577e1f1c51c380a903c0983</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4123,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24517031$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Awhin, E P</creatorcontrib><creatorcontrib>Jeroh, E</creatorcontrib><creatorcontrib>Anigboro, A A</creatorcontrib><creatorcontrib>Rachael, Nwaoroko</creatorcontrib><title>Effect of chronic consumption of Piliostigma thonningii on activities of alanine aminotransferase and aspartate aminotransferase in serum and liver in Rattus novergicus</title><title>Pakistan journal of biological sciences</title><addtitle>Pak J Biol Sci</addtitle><description>The effect of chronic consumption of Piliostigma thonningii on the activities of Aspartate Aminotransferases (AST) and Alanine Aminotransferases (ALT) on serum and liver of Rattus novergicus was investigated in this research. The aim of this study was to check the possible effect of chronic consumption of Piliostigma thonningii on the activities of the liver biomarkers (ALT and AST) in Rattus novergicus. The results from this study revealed that the activities of aspartate aminotransferase (AST) in serum, showed a significant increase (34.20 +/- 12.9*) at (p < 0.05) upon chronic consumption of ethanolic extract of P. thonningii when compared with that of the control B (18.02 +/- 1.54). The result also showed that the liver AST was significantly increased (32.75 +/- 5.89*) when compared to that of the control B (17.01 +/- 1.81) at (p < 0.05). The results from the study also revealed that there was a significant increase in the activity of alanine aminotransferase in the liver (17.01 +/- 5.86*) when compared with that of the control B (5.1 +/- 1.11) at (p < 0.05). There was a corresponding increase in serum activity of the enzyme ALT (13.65 +/- 3.79*) when compared with that of the control B (9.4 +/- 1.98) at (p < 0.05). The results from this research has shown that chronic consumption of P. thonningii may cause liver injury thereby, increasing the liver enzyme activity (17.01 +/- 5.86*). This was shown in the corresponding increase in the serum level. Excessive consumption of the extract of P. thonningii has a toxicity potential on the liver and possibly other organs and tissues.</description><subject>Alanine Transaminase - blood</subject><subject>Animals</subject><subject>Aspartate Aminotransferases - blood</subject><subject>Biomarkers - blood</subject><subject>Chemical and Drug Induced Liver Injury - blood</subject><subject>Chemical and Drug Induced Liver Injury - enzymology</subject><subject>Chemical and Drug Induced Liver Injury - etiology</subject><subject>Ethanol - chemistry</subject><subject>Fabaceae</subject><subject>Female</subject><subject>Liver - drug effects</subject><subject>Liver - enzymology</subject><subject>Male</subject><subject>Phytotherapy</subject><subject>Plant Bark</subject><subject>Plant Extracts - administration & dosage</subject><subject>Plant Extracts - toxicity</subject><subject>Plants, Medicinal</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Rattus</subject><subject>Solvents - chemistry</subject><subject>Time Factors</subject><subject>Up-Regulation</subject><issn>1028-8880</issn><issn>1812-5735</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUc1u3iAQRFWjJk37BJUqjrk4BdbY-FhF6Y8UqVWUnC2M4QuRDS6LI_WN-piFJu0pUi-z7MwsaBlC3nF2DoOAD9v9hOeCcSjQiQryBTnhiotG9iBfljMTqlFKsWPyGvGesbYXvXpFjkUrec-An5Bfl85Zk2l01NylGLyhJgbc1y37GCr93S8-YvaHVdN8F0Pw4eA9LaI22T_47C1Wn150kSzVqw8xJx3Q2aSxEGGmGjedss7PyD5QtGlf__gW_2BTpa51zjvSEEt_8GbHN-TI6QXt26d6Sm4_Xd5cfGmuvn3-evHxqjFCQm4mBm5QZtZqsnw2js0grYYeWs06p7qBGznBDM7KvrfclZYbUEwPDAwbFJySs8d7txR_7BbzuHo0dinb2bjjyDvVd51g5fv-a22HgbdKdG2xwqPVpIiYrBu35Fedfo6cjTXNsaY51jTHmmYFWabePz2wT6ud_838jQ9-A1JqoL0</recordid><startdate>20131215</startdate><enddate>20131215</enddate><creator>Awhin, E P</creator><creator>Jeroh, E</creator><creator>Anigboro, A A</creator><creator>Rachael, Nwaoroko</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20131215</creationdate><title>Effect of chronic consumption of Piliostigma thonningii on activities of alanine aminotransferase and aspartate aminotransferase in serum and liver in Rattus novergicus</title><author>Awhin, E P ; Jeroh, E ; Anigboro, A A ; Rachael, Nwaoroko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c253t-b03f98cda8be1dcf0d35ea3734a06f8691c5b3d3fe577e1f1c51c380a903c0983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Alanine Transaminase - blood</topic><topic>Animals</topic><topic>Aspartate Aminotransferases - blood</topic><topic>Biomarkers - blood</topic><topic>Chemical and Drug Induced Liver Injury - blood</topic><topic>Chemical and Drug Induced Liver Injury - enzymology</topic><topic>Chemical and Drug Induced Liver Injury - etiology</topic><topic>Ethanol - chemistry</topic><topic>Fabaceae</topic><topic>Female</topic><topic>Liver - drug effects</topic><topic>Liver - enzymology</topic><topic>Male</topic><topic>Phytotherapy</topic><topic>Plant Bark</topic><topic>Plant Extracts - administration & dosage</topic><topic>Plant Extracts - toxicity</topic><topic>Plants, Medicinal</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Rattus</topic><topic>Solvents - chemistry</topic><topic>Time Factors</topic><topic>Up-Regulation</topic><toplevel>online_resources</toplevel><creatorcontrib>Awhin, E P</creatorcontrib><creatorcontrib>Jeroh, E</creatorcontrib><creatorcontrib>Anigboro, A A</creatorcontrib><creatorcontrib>Rachael, Nwaoroko</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Pakistan journal of biological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Awhin, E P</au><au>Jeroh, E</au><au>Anigboro, A A</au><au>Rachael, Nwaoroko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of chronic consumption of Piliostigma thonningii on activities of alanine aminotransferase and aspartate aminotransferase in serum and liver in Rattus novergicus</atitle><jtitle>Pakistan journal of biological sciences</jtitle><addtitle>Pak J Biol Sci</addtitle><date>2013-12-15</date><risdate>2013</risdate><volume>16</volume><issue>24</issue><spage>2062</spage><epage>2065</epage><pages>2062-2065</pages><issn>1028-8880</issn><eissn>1812-5735</eissn><abstract>The effect of chronic consumption of Piliostigma thonningii on the activities of Aspartate Aminotransferases (AST) and Alanine Aminotransferases (ALT) on serum and liver of Rattus novergicus was investigated in this research. The aim of this study was to check the possible effect of chronic consumption of Piliostigma thonningii on the activities of the liver biomarkers (ALT and AST) in Rattus novergicus. The results from this study revealed that the activities of aspartate aminotransferase (AST) in serum, showed a significant increase (34.20 +/- 12.9*) at (p < 0.05) upon chronic consumption of ethanolic extract of P. thonningii when compared with that of the control B (18.02 +/- 1.54). The result also showed that the liver AST was significantly increased (32.75 +/- 5.89*) when compared to that of the control B (17.01 +/- 1.81) at (p < 0.05). The results from the study also revealed that there was a significant increase in the activity of alanine aminotransferase in the liver (17.01 +/- 5.86*) when compared with that of the control B (5.1 +/- 1.11) at (p < 0.05). There was a corresponding increase in serum activity of the enzyme ALT (13.65 +/- 3.79*) when compared with that of the control B (9.4 +/- 1.98) at (p < 0.05). The results from this research has shown that chronic consumption of P. thonningii may cause liver injury thereby, increasing the liver enzyme activity (17.01 +/- 5.86*). This was shown in the corresponding increase in the serum level. Excessive consumption of the extract of P. thonningii has a toxicity potential on the liver and possibly other organs and tissues.</abstract><cop>Pakistan</cop><pmid>24517031</pmid><doi>10.3923/pjbs.2013.2062.2065</doi><tpages>4</tpages></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Science Alert |
| subjects | Alanine Transaminase - blood Animals Aspartate Aminotransferases - blood Biomarkers - blood Chemical and Drug Induced Liver Injury - blood Chemical and Drug Induced Liver Injury - enzymology Chemical and Drug Induced Liver Injury - etiology Ethanol - chemistry Fabaceae Female Liver - drug effects Liver - enzymology Male Phytotherapy Plant Bark Plant Extracts - administration & dosage Plant Extracts - toxicity Plants, Medicinal Rats Rats, Wistar Rattus Solvents - chemistry Time Factors Up-Regulation |
| title | Effect of chronic consumption of Piliostigma thonningii on activities of alanine aminotransferase and aspartate aminotransferase in serum and liver in Rattus novergicus |
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