Docosahexaenoic acid alters Gsα localization in lipid raft and potentiates adenylate cyclase

Abstract Objective Supplementation with docosahexaenoic acid (DHA), an ω-3 polyunsaturated fatty acid (PUFA), recently has become popular for the amelioration of depression; however the molecular mechanism of DHA action remains unclear. The aim of this study was to investigate the mechanism underlyi...

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Veröffentlicht in:	Nutrition (Burbank, Los Angeles County, Calif.) Los Angeles County, Calif.), 2015-07, Vol.31 (7), p.1025-1030
Hauptverfasser:	Zhu, Zhuoran, M.D, Tan, Zhoubin, M.D, Li, Yan, M.S, Luo, Hongyan, B.S, Hu, Xinwu, B.S, Tang, Ming, B.S, Hescheler, Jürgen, Ph.D, Mu, Yangling, Ph.D, Zhang, Lanqiu, M.D., Ph.D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenylate cyclase Adenylyl Cyclases - metabolism Animals Antidepressant Antidepressive Agents - pharmacology Cell Line, Tumor Cyclic AMP - analysis Docosahexaenoic acid Docosahexaenoic Acids - pharmacology Gastroenterology and Hepatology Gsα GTP-Binding Protein alpha Subunits, Gs - metabolism Lipid raft Membrane Microdomains - drug effects Membrane Microdomains - pathology Rats Signal Transduction - drug effects
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