Vitreous and Aqueous Penetration of Orally Administered Trimethoprim-Sulfamethoxazole Combination in Humans
To determine the penetration of orally administered trimethoprim (TMP)-sulfamethoxazole (SMX) into the aqueous and vitreous cavity of noninflamed human eyes. Nine adult patients undergoing cataract surgery and 10 adult patients undergoing pars plana vitrectomy were given 3 doses of oral TMP-SMX ever...
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| Veröffentlicht in: | Cornea 2013-10, Vol.32 (10), p.1315-1320 |
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| creator | Feiz, Vahid Nijm, Lisa Glickman, Randolph D Morse, Lawrence S Telander, David G Park, Susanna S Polage, Christopher R Christiansen, Steven M Moshirfar, Majid |
| description | To determine the penetration of orally administered trimethoprim (TMP)-sulfamethoxazole (SMX) into the aqueous and vitreous cavity of noninflamed human eyes.
Nine adult patients undergoing cataract surgery and 10 adult patients undergoing pars plana vitrectomy were given 3 doses of oral TMP-SMX every 12 hours before the surgery. Aqueous and blood samples were collected from patients undergoing cataract surgery; vitreous and blood samples were collected from patients undergoing vitrectomy. The levels of TMP and SMX were analyzed using high-performance liquid chromatography and were compared with the mean minimum inhibitory concentrations (MIC) of potential ocular pathogens.
TMP-SMX was present in all samples. Among eyes undergoing cataract surgery, the mean concentrations of TMP in aqueous and blood were 0.341 ± 0.141 μg/mL (mean ± SD) and 1.501 ± 0.433 μg/mL and of SMX were 5.259 ± 0.929 μg/mL and 11.835 ± 2.100 μg/mL, respectively. Among eyes undergoing vitrectomy, the mean concentrations of TMP in vitreous and blood were 1.864 ± 0.807 μg/mL and 4.591 ± 2.979 μg/mL and of SMX were 5.910 ± 2.705 μg/mL and 39.289 ± 15.469 μg/mL, respectively. MIC levels were achieved against many bacterial pathogens, including methicillin-resistant Staphylococcus aureus.
TMP-SMX penetrates both the aqueous and vitreous cavities when given orally. The components reach therapeutic inhibitory concentrations in the ocular cavity against many potential pathogens. |
| doi_str_mv | 10.1097/ICO.0b013e318298ddf8 |
| format | Article |
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Nine adult patients undergoing cataract surgery and 10 adult patients undergoing pars plana vitrectomy were given 3 doses of oral TMP-SMX every 12 hours before the surgery. Aqueous and blood samples were collected from patients undergoing cataract surgery; vitreous and blood samples were collected from patients undergoing vitrectomy. The levels of TMP and SMX were analyzed using high-performance liquid chromatography and were compared with the mean minimum inhibitory concentrations (MIC) of potential ocular pathogens.
TMP-SMX was present in all samples. Among eyes undergoing cataract surgery, the mean concentrations of TMP in aqueous and blood were 0.341 ± 0.141 μg/mL (mean ± SD) and 1.501 ± 0.433 μg/mL and of SMX were 5.259 ± 0.929 μg/mL and 11.835 ± 2.100 μg/mL, respectively. Among eyes undergoing vitrectomy, the mean concentrations of TMP in vitreous and blood were 1.864 ± 0.807 μg/mL and 4.591 ± 2.979 μg/mL and of SMX were 5.910 ± 2.705 μg/mL and 39.289 ± 15.469 μg/mL, respectively. MIC levels were achieved against many bacterial pathogens, including methicillin-resistant Staphylococcus aureus.
TMP-SMX penetrates both the aqueous and vitreous cavities when given orally. The components reach therapeutic inhibitory concentrations in the ocular cavity against many potential pathogens.</description><identifier>ISSN: 0277-3740</identifier><identifier>EISSN: 1536-4798</identifier><identifier>DOI: 10.1097/ICO.0b013e318298ddf8</identifier><identifier>PMID: 23928948</identifier><language>eng</language><publisher>United States</publisher><subject>Administration, Oral ; Aged ; Aged, 80 and over ; Anti-Bacterial Agents - pharmacokinetics ; Aqueous Humor - metabolism ; Bacteria - drug effects ; Biological Availability ; Cataract Extraction ; Chromatography, High Pressure Liquid ; Humans ; Microbial Sensitivity Tests ; Middle Aged ; Tissue Distribution ; Trimethoprim, Sulfamethoxazole Drug Combination - pharmacokinetics ; Vitrectomy ; Vitreous Body - metabolism</subject><ispartof>Cornea, 2013-10, Vol.32 (10), p.1315-1320</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c307t-a193ae937f15aadc8b21703984ad96210465a16fa446c861687222d92d00247d3</citedby><cites>FETCH-LOGICAL-c307t-a193ae937f15aadc8b21703984ad96210465a16fa446c861687222d92d00247d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23928948$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Feiz, Vahid</creatorcontrib><creatorcontrib>Nijm, Lisa</creatorcontrib><creatorcontrib>Glickman, Randolph D</creatorcontrib><creatorcontrib>Morse, Lawrence S</creatorcontrib><creatorcontrib>Telander, David G</creatorcontrib><creatorcontrib>Park, Susanna S</creatorcontrib><creatorcontrib>Polage, Christopher R</creatorcontrib><creatorcontrib>Christiansen, Steven M</creatorcontrib><creatorcontrib>Moshirfar, Majid</creatorcontrib><title>Vitreous and Aqueous Penetration of Orally Administered Trimethoprim-Sulfamethoxazole Combination in Humans</title><title>Cornea</title><addtitle>Cornea</addtitle><description>To determine the penetration of orally administered trimethoprim (TMP)-sulfamethoxazole (SMX) into the aqueous and vitreous cavity of noninflamed human eyes.
Nine adult patients undergoing cataract surgery and 10 adult patients undergoing pars plana vitrectomy were given 3 doses of oral TMP-SMX every 12 hours before the surgery. Aqueous and blood samples were collected from patients undergoing cataract surgery; vitreous and blood samples were collected from patients undergoing vitrectomy. The levels of TMP and SMX were analyzed using high-performance liquid chromatography and were compared with the mean minimum inhibitory concentrations (MIC) of potential ocular pathogens.
TMP-SMX was present in all samples. Among eyes undergoing cataract surgery, the mean concentrations of TMP in aqueous and blood were 0.341 ± 0.141 μg/mL (mean ± SD) and 1.501 ± 0.433 μg/mL and of SMX were 5.259 ± 0.929 μg/mL and 11.835 ± 2.100 μg/mL, respectively. Among eyes undergoing vitrectomy, the mean concentrations of TMP in vitreous and blood were 1.864 ± 0.807 μg/mL and 4.591 ± 2.979 μg/mL and of SMX were 5.910 ± 2.705 μg/mL and 39.289 ± 15.469 μg/mL, respectively. MIC levels were achieved against many bacterial pathogens, including methicillin-resistant Staphylococcus aureus.
TMP-SMX penetrates both the aqueous and vitreous cavities when given orally. The components reach therapeutic inhibitory concentrations in the ocular cavity against many potential pathogens.</description><subject>Administration, Oral</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anti-Bacterial Agents - pharmacokinetics</subject><subject>Aqueous Humor - metabolism</subject><subject>Bacteria - drug effects</subject><subject>Biological Availability</subject><subject>Cataract Extraction</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Humans</subject><subject>Microbial Sensitivity Tests</subject><subject>Middle Aged</subject><subject>Tissue Distribution</subject><subject>Trimethoprim, Sulfamethoxazole Drug Combination - pharmacokinetics</subject><subject>Vitrectomy</subject><subject>Vitreous Body - metabolism</subject><issn>0277-3740</issn><issn>1536-4798</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkEtLw0AUhQdRbK3-A5FZukmdV-exLEFtoVDB6jZMMhMcTSZ1JgHrrzdpqwtX914451zOB8A1RlOMlLhbpuspyhGmlmJJlDSmlCdgjGeUJ0woeQrGiAiRUMHQCFzE-I4QEoKTczAiVBGpmByDj1fXBtt0EWpv4Pyz2-9P1ts26NY1HjYlXAddVTs4N7XzLrY2WAM3wdW2fWu2_Uyeu6rU-_NLfzeVhWlT584fApyHi67WPl6Cs1JX0V4d5wS8PNxv0kWyWj8u0_kqKSgSbaKxotoqKko809oUMidYIKok00ZxghHjM415qRnjheSYS0EIMYoYhAgThk7A7SF3G5q-UGyz2sXCVpX2Q7tscHCGpRS9lB2kRWhiDLbMhj467DKMsgFz1mPO_mPubTfHD11eW_Nn-uVKfwA-untF</recordid><startdate>201310</startdate><enddate>201310</enddate><creator>Feiz, Vahid</creator><creator>Nijm, Lisa</creator><creator>Glickman, Randolph D</creator><creator>Morse, Lawrence S</creator><creator>Telander, David G</creator><creator>Park, Susanna S</creator><creator>Polage, Christopher R</creator><creator>Christiansen, Steven M</creator><creator>Moshirfar, Majid</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201310</creationdate><title>Vitreous and Aqueous Penetration of Orally Administered Trimethoprim-Sulfamethoxazole Combination in Humans</title><author>Feiz, Vahid ; Nijm, Lisa ; Glickman, Randolph D ; Morse, Lawrence S ; Telander, David G ; Park, Susanna S ; Polage, Christopher R ; Christiansen, Steven M ; Moshirfar, Majid</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c307t-a193ae937f15aadc8b21703984ad96210465a16fa446c861687222d92d00247d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Administration, Oral</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anti-Bacterial Agents - pharmacokinetics</topic><topic>Aqueous Humor - metabolism</topic><topic>Bacteria - drug effects</topic><topic>Biological Availability</topic><topic>Cataract Extraction</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Humans</topic><topic>Microbial Sensitivity Tests</topic><topic>Middle Aged</topic><topic>Tissue Distribution</topic><topic>Trimethoprim, Sulfamethoxazole Drug Combination - pharmacokinetics</topic><topic>Vitrectomy</topic><topic>Vitreous Body - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Feiz, Vahid</creatorcontrib><creatorcontrib>Nijm, Lisa</creatorcontrib><creatorcontrib>Glickman, Randolph D</creatorcontrib><creatorcontrib>Morse, Lawrence S</creatorcontrib><creatorcontrib>Telander, David G</creatorcontrib><creatorcontrib>Park, Susanna S</creatorcontrib><creatorcontrib>Polage, Christopher R</creatorcontrib><creatorcontrib>Christiansen, Steven M</creatorcontrib><creatorcontrib>Moshirfar, Majid</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cornea</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Feiz, Vahid</au><au>Nijm, Lisa</au><au>Glickman, Randolph D</au><au>Morse, Lawrence S</au><au>Telander, David G</au><au>Park, Susanna S</au><au>Polage, Christopher R</au><au>Christiansen, Steven M</au><au>Moshirfar, Majid</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vitreous and Aqueous Penetration of Orally Administered Trimethoprim-Sulfamethoxazole Combination in Humans</atitle><jtitle>Cornea</jtitle><addtitle>Cornea</addtitle><date>2013-10</date><risdate>2013</risdate><volume>32</volume><issue>10</issue><spage>1315</spage><epage>1320</epage><pages>1315-1320</pages><issn>0277-3740</issn><eissn>1536-4798</eissn><abstract>To determine the penetration of orally administered trimethoprim (TMP)-sulfamethoxazole (SMX) into the aqueous and vitreous cavity of noninflamed human eyes.
Nine adult patients undergoing cataract surgery and 10 adult patients undergoing pars plana vitrectomy were given 3 doses of oral TMP-SMX every 12 hours before the surgery. Aqueous and blood samples were collected from patients undergoing cataract surgery; vitreous and blood samples were collected from patients undergoing vitrectomy. The levels of TMP and SMX were analyzed using high-performance liquid chromatography and were compared with the mean minimum inhibitory concentrations (MIC) of potential ocular pathogens.
TMP-SMX was present in all samples. Among eyes undergoing cataract surgery, the mean concentrations of TMP in aqueous and blood were 0.341 ± 0.141 μg/mL (mean ± SD) and 1.501 ± 0.433 μg/mL and of SMX were 5.259 ± 0.929 μg/mL and 11.835 ± 2.100 μg/mL, respectively. Among eyes undergoing vitrectomy, the mean concentrations of TMP in vitreous and blood were 1.864 ± 0.807 μg/mL and 4.591 ± 2.979 μg/mL and of SMX were 5.910 ± 2.705 μg/mL and 39.289 ± 15.469 μg/mL, respectively. MIC levels were achieved against many bacterial pathogens, including methicillin-resistant Staphylococcus aureus.
TMP-SMX penetrates both the aqueous and vitreous cavities when given orally. The components reach therapeutic inhibitory concentrations in the ocular cavity against many potential pathogens.</abstract><cop>United States</cop><pmid>23928948</pmid><doi>10.1097/ICO.0b013e318298ddf8</doi><tpages>6</tpages></addata></record> |
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| subjects | Administration, Oral Aged Aged, 80 and over Anti-Bacterial Agents - pharmacokinetics Aqueous Humor - metabolism Bacteria - drug effects Biological Availability Cataract Extraction Chromatography, High Pressure Liquid Humans Microbial Sensitivity Tests Middle Aged Tissue Distribution Trimethoprim, Sulfamethoxazole Drug Combination - pharmacokinetics Vitrectomy Vitreous Body - metabolism |
| title | Vitreous and Aqueous Penetration of Orally Administered Trimethoprim-Sulfamethoxazole Combination in Humans |
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