Sterol liganding of OSBP-related proteins (ORPs) regulates the subcellular distribution of ORP–VAPA complexes and their impacts on organelle structure

•Effects of HuH7 cell sterol manipulations on ORP–VAP complexes were assayed with BiFC.•Treatments with 25OHC or 22(R)OHC reduced cellular free and total cholesterol.•Statin treatment or 25OHC moved scattered OSBP–VAP to a clustered Golgi complex.•Statin treatment or 25OHC redistributed ORP4–VAP and...

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Veröffentlicht in:	Steroids 2015-07, Vol.99 (Pt B), p.248-258
Hauptverfasser:	Kentala, Henriikka, Pfisterer, Simon G., Olkkonen, Vesa M., Weber-Boyvat, Marion
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line, Tumor Cholesterol Fluorescence Golgi Apparatus - drug effects Golgi Apparatus - metabolism Humans Hydroxycholesterols - pharmacology Intracellular Space - metabolism Ligands Lipid signaling Lipid transport Multiprotein Complexes - metabolism Organelles - drug effects Organelles - metabolism Oxysterol Oxysterol-binding protein Protein Transport - drug effects Receptors, Steroid - metabolism Sterols - metabolism Subcellular Fractions - metabolism Triglycerides - metabolism VAMP-associated protein Vesicular Transport Proteins - metabolism Vimentin - metabolism
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