Loss of PCDH9 is associated with the differentiation of tumor cells and metastasis and predicts poor survival in gastric cancer
Microarray studies revealed down-regulation of PCDH9 mRNA level in lymph node metastasis of gastric cancer compared with the primary tumors. The expression of PCDH9 protein and its clinicopathological relevance were assessed on tissue microarrays of 1072 cases of gastric cancer. Its prognostic value...
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| Veröffentlicht in: | Clinical & experimental metastasis 2015-06, Vol.32 (5), p.417-428 |
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| creator | Chen, Ying Xiang, Honggang Zhang, Yingfan Wang, Jiejun Yu, Guanzhen |
| description | Microarray studies revealed down-regulation of PCDH9 mRNA level in lymph node metastasis of gastric cancer compared with the primary tumors. The expression of PCDH9 protein and its clinicopathological relevance were assessed on tissue microarrays of 1072 cases of gastric cancer. Its prognostic value was further evaluated on a small cohort of 175 gastric cancers. PCDH9 was down-regulated during the development and progression of gastric cancer. The overall rates of PCDH9 expression in normal, primary tumor, nodal and hepatic metastatic tissues were 100 % (1072/1072), 48.0 % (515/1072), 20.1 % (34/169), and 5.6 % (1/18), respectively. Positive staining of PCDH9 protein was significantly reversely correlated with tumor size, tumor differentiation, tumor invasion, lymph node metastasis, and disease progression. The Cox proportional hazards model revealed that the PCDH9 was an independent prognostic factor for gastric cancer. Therefore, decreased expression of PCDH9 is frequent in human gastric cancer metastasis and PCDH9 expression is an independent prognostic factor, suggesting that PCDH9 could be a promising biomarker of this malignancy. |
| doi_str_mv | 10.1007/s10585-015-9712-7 |
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The expression of PCDH9 protein and its clinicopathological relevance were assessed on tissue microarrays of 1072 cases of gastric cancer. Its prognostic value was further evaluated on a small cohort of 175 gastric cancers. PCDH9 was down-regulated during the development and progression of gastric cancer. The overall rates of PCDH9 expression in normal, primary tumor, nodal and hepatic metastatic tissues were 100 % (1072/1072), 48.0 % (515/1072), 20.1 % (34/169), and 5.6 % (1/18), respectively. Positive staining of PCDH9 protein was significantly reversely correlated with tumor size, tumor differentiation, tumor invasion, lymph node metastasis, and disease progression. The Cox proportional hazards model revealed that the PCDH9 was an independent prognostic factor for gastric cancer. Therefore, decreased expression of PCDH9 is frequent in human gastric cancer metastasis and PCDH9 expression is an independent prognostic factor, suggesting that PCDH9 could be a promising biomarker of this malignancy.</description><identifier>ISSN: 0262-0898</identifier><identifier>EISSN: 1573-7276</identifier><identifier>DOI: 10.1007/s10585-015-9712-7</identifier><identifier>PMID: 25869928</identifier><identifier>CODEN: CEXMD2</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Biomarkers, Tumor - genetics ; Biomarkers, Tumor - metabolism ; Biomedical and Life Sciences ; Biomedicine ; Cadherins - genetics ; Cadherins - metabolism ; Cancer Research ; Cell Differentiation ; Cohort Studies ; Disease Progression ; DNA Mutational Analysis ; Female ; Hematology ; Humans ; Immunoenzyme Techniques ; Liver Neoplasms - metabolism ; Liver Neoplasms - mortality ; Liver Neoplasms - secondary ; Lymphatic Metastasis ; Male ; Middle Aged ; Mutation - genetics ; Neoplasm Invasiveness ; Neoplasm Staging ; Oncology ; Prognosis ; Real-Time Polymerase Chain Reaction ; Research Paper ; Reverse Transcriptase Polymerase Chain Reaction ; RNA, Messenger - genetics ; Stomach - metabolism ; Stomach Neoplasms - metabolism ; Stomach Neoplasms - mortality ; Stomach Neoplasms - pathology ; Surgical Oncology ; Survival Rate ; Tissue Array Analysis ; Tumor Cells, Cultured</subject><ispartof>Clinical & experimental metastasis, 2015-06, Vol.32 (5), p.417-428</ispartof><rights>Springer Science+Business Media Dordrecht 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-193428976da684a5b0449ae59f0f2c28d896d2f47b1f22577e53d0f5a5b2ee563</citedby><cites>FETCH-LOGICAL-c372t-193428976da684a5b0449ae59f0f2c28d896d2f47b1f22577e53d0f5a5b2ee563</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10585-015-9712-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10585-015-9712-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27929,27930,41493,42562,51324</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25869928$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Ying</creatorcontrib><creatorcontrib>Xiang, Honggang</creatorcontrib><creatorcontrib>Zhang, Yingfan</creatorcontrib><creatorcontrib>Wang, Jiejun</creatorcontrib><creatorcontrib>Yu, Guanzhen</creatorcontrib><title>Loss of PCDH9 is associated with the differentiation of tumor cells and metastasis and predicts poor survival in gastric cancer</title><title>Clinical & experimental metastasis</title><addtitle>Clin Exp Metastasis</addtitle><addtitle>Clin Exp Metastasis</addtitle><description>Microarray studies revealed down-regulation of PCDH9 mRNA level in lymph node metastasis of gastric cancer compared with the primary tumors. The expression of PCDH9 protein and its clinicopathological relevance were assessed on tissue microarrays of 1072 cases of gastric cancer. Its prognostic value was further evaluated on a small cohort of 175 gastric cancers. PCDH9 was down-regulated during the development and progression of gastric cancer. The overall rates of PCDH9 expression in normal, primary tumor, nodal and hepatic metastatic tissues were 100 % (1072/1072), 48.0 % (515/1072), 20.1 % (34/169), and 5.6 % (1/18), respectively. Positive staining of PCDH9 protein was significantly reversely correlated with tumor size, tumor differentiation, tumor invasion, lymph node metastasis, and disease progression. The Cox proportional hazards model revealed that the PCDH9 was an independent prognostic factor for gastric cancer. Therefore, decreased expression of PCDH9 is frequent in human gastric cancer metastasis and PCDH9 expression is an independent prognostic factor, suggesting that PCDH9 could be a promising biomarker of this malignancy.</description><subject>Biomarkers, Tumor - genetics</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cadherins - genetics</subject><subject>Cadherins - metabolism</subject><subject>Cancer Research</subject><subject>Cell Differentiation</subject><subject>Cohort Studies</subject><subject>Disease Progression</subject><subject>DNA Mutational Analysis</subject><subject>Female</subject><subject>Hematology</subject><subject>Humans</subject><subject>Immunoenzyme Techniques</subject><subject>Liver Neoplasms - metabolism</subject><subject>Liver Neoplasms - mortality</subject><subject>Liver Neoplasms - secondary</subject><subject>Lymphatic Metastasis</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mutation - genetics</subject><subject>Neoplasm Invasiveness</subject><subject>Neoplasm Staging</subject><subject>Oncology</subject><subject>Prognosis</subject><subject>Real-Time Polymerase Chain Reaction</subject><subject>Research Paper</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>RNA, Messenger - genetics</subject><subject>Stomach - metabolism</subject><subject>Stomach Neoplasms - metabolism</subject><subject>Stomach Neoplasms - mortality</subject><subject>Stomach Neoplasms - pathology</subject><subject>Surgical Oncology</subject><subject>Survival Rate</subject><subject>Tissue Array Analysis</subject><subject>Tumor Cells, Cultured</subject><issn>0262-0898</issn><issn>1573-7276</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kU9rFTEUxYMo9rX6AdxIwI2b0SQz-beUV7XCg3ZR1yEvuWlT3kyeSabiyq_eDNOKCJILITe_c3LJQegNJR8oIfJjoYQr3hHKOy0p6-QztKFc9p1kUjxHG8IE64jS6gSdlnJHCBmkVC_RCeNKaM3UBv3epVJwCvhqe36hcSzYlpJctBU8_hnrLa63gH0MATJMtfVjmha-zmPK2MHh0CSTxyNUW1rF9XjM4KOrBR9Tw8qc7-O9PeA44ZuG5eiws5OD_Aq9CPZQ4PXjfoa-f_l8vb3odpdfv20_7TrXS1Y7qvuBKS2Ft0INlu_JMGgLXAcSmGPKKy08C4Pc08AYlxJ470ngjWQAXPRn6P3qe8zpxwylmjGWZXo7QZqLoULJflCD0g199w96l-Y8tekWSsi29ELRlXK5_WCGYI45jjb_MpSYJR2zpmNaOmZJx8imefvoPO9H8H8UT3E0gK1AaVfTDeS_nv6v6wN2h5qq</recordid><startdate>20150601</startdate><enddate>20150601</enddate><creator>Chen, Ying</creator><creator>Xiang, Honggang</creator><creator>Zhang, Yingfan</creator><creator>Wang, Jiejun</creator><creator>Yu, Guanzhen</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FG</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20150601</creationdate><title>Loss of PCDH9 is associated with the differentiation of tumor cells and metastasis and predicts poor survival in gastric cancer</title><author>Chen, Ying ; Xiang, Honggang ; Zhang, Yingfan ; Wang, Jiejun ; Yu, Guanzhen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-193428976da684a5b0449ae59f0f2c28d896d2f47b1f22577e53d0f5a5b2ee563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Biomarkers, Tumor - genetics</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cadherins - genetics</topic><topic>Cadherins - metabolism</topic><topic>Cancer Research</topic><topic>Cell Differentiation</topic><topic>Cohort Studies</topic><topic>Disease Progression</topic><topic>DNA Mutational Analysis</topic><topic>Female</topic><topic>Hematology</topic><topic>Humans</topic><topic>Immunoenzyme Techniques</topic><topic>Liver Neoplasms - metabolism</topic><topic>Liver Neoplasms - mortality</topic><topic>Liver Neoplasms - secondary</topic><topic>Lymphatic Metastasis</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mutation - genetics</topic><topic>Neoplasm Invasiveness</topic><topic>Neoplasm Staging</topic><topic>Oncology</topic><topic>Prognosis</topic><topic>Real-Time Polymerase Chain Reaction</topic><topic>Research Paper</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>RNA, Messenger - genetics</topic><topic>Stomach - metabolism</topic><topic>Stomach Neoplasms - metabolism</topic><topic>Stomach Neoplasms - mortality</topic><topic>Stomach Neoplasms - pathology</topic><topic>Surgical Oncology</topic><topic>Survival Rate</topic><topic>Tissue Array Analysis</topic><topic>Tumor Cells, Cultured</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Ying</creatorcontrib><creatorcontrib>Xiang, Honggang</creatorcontrib><creatorcontrib>Zhang, Yingfan</creatorcontrib><creatorcontrib>Wang, Jiejun</creatorcontrib><creatorcontrib>Yu, Guanzhen</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical & experimental metastasis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Ying</au><au>Xiang, Honggang</au><au>Zhang, Yingfan</au><au>Wang, Jiejun</au><au>Yu, Guanzhen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Loss of PCDH9 is associated with the differentiation of tumor cells and metastasis and predicts poor survival in gastric cancer</atitle><jtitle>Clinical & experimental metastasis</jtitle><stitle>Clin Exp Metastasis</stitle><addtitle>Clin Exp Metastasis</addtitle><date>2015-06-01</date><risdate>2015</risdate><volume>32</volume><issue>5</issue><spage>417</spage><epage>428</epage><pages>417-428</pages><issn>0262-0898</issn><eissn>1573-7276</eissn><coden>CEXMD2</coden><abstract>Microarray studies revealed down-regulation of PCDH9 mRNA level in lymph node metastasis of gastric cancer compared with the primary tumors. The expression of PCDH9 protein and its clinicopathological relevance were assessed on tissue microarrays of 1072 cases of gastric cancer. Its prognostic value was further evaluated on a small cohort of 175 gastric cancers. PCDH9 was down-regulated during the development and progression of gastric cancer. The overall rates of PCDH9 expression in normal, primary tumor, nodal and hepatic metastatic tissues were 100 % (1072/1072), 48.0 % (515/1072), 20.1 % (34/169), and 5.6 % (1/18), respectively. Positive staining of PCDH9 protein was significantly reversely correlated with tumor size, tumor differentiation, tumor invasion, lymph node metastasis, and disease progression. The Cox proportional hazards model revealed that the PCDH9 was an independent prognostic factor for gastric cancer. Therefore, decreased expression of PCDH9 is frequent in human gastric cancer metastasis and PCDH9 expression is an independent prognostic factor, suggesting that PCDH9 could be a promising biomarker of this malignancy.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>25869928</pmid><doi>10.1007/s10585-015-9712-7</doi><tpages>12</tpages></addata></record> |
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| subjects | Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Biomedical and Life Sciences Biomedicine Cadherins - genetics Cadherins - metabolism Cancer Research Cell Differentiation Cohort Studies Disease Progression DNA Mutational Analysis Female Hematology Humans Immunoenzyme Techniques Liver Neoplasms - metabolism Liver Neoplasms - mortality Liver Neoplasms - secondary Lymphatic Metastasis Male Middle Aged Mutation - genetics Neoplasm Invasiveness Neoplasm Staging Oncology Prognosis Real-Time Polymerase Chain Reaction Research Paper Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Stomach - metabolism Stomach Neoplasms - metabolism Stomach Neoplasms - mortality Stomach Neoplasms - pathology Surgical Oncology Survival Rate Tissue Array Analysis Tumor Cells, Cultured |
| title | Loss of PCDH9 is associated with the differentiation of tumor cells and metastasis and predicts poor survival in gastric cancer |
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