The different expression profiles of microRNAs in elderly and young human dental pulp and the role of miR-433 in human dental pulp cells

•Conduct expression profiles of miRNAs in HDPCs of young and elderly people.•MiR-433 was most up-regulated in the aging group and direct target GRB2.•MiR-433 control the RAS–MAPK signaling pathway by negatively regulating GRB2.•MiR-433 can affect HDPCs biological behavior and function during senesce...

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Veröffentlicht in:	Mechanisms of ageing and development 2015-03, Vol.146-148, p.1-11
Hauptverfasser:	Wang, Kejing, Li, Li, Wu, Junjun, Qiu, Qin, Zhou, Fengjuan, Wu, Hongkun
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aging - metabolism Apoptosis - physiology Cell Proliferation - physiology Cells, Cultured Cellular Senescence - physiology Dental Pulp - cytology Dental Pulp - metabolism Gene Expression Regulation - physiology GRB2 Human dental pulp cell Humans Male MAP Kinase Signaling System - physiology MicroRNAs MicroRNAs - biosynthesis RAS–MAPK signaling pathways Senescence
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