Mechanisms that lead to the regulation of NLRP3 inflammasome expression and activation in human dental pulp fibroblasts

The NLRP3 inflammasome plays an important role in the cellular defense against invading pathogens and is reported to be expressed in human dental pulp fibroblasts (HDPFs). However, the role of the NLRP3 inflammasome in HDPFs during pulpal infection and inflammation remains unclear. To elucidate the...

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Veröffentlicht in:	Molecular immunology 2015-08, Vol.66 (2), p.253-262
Hauptverfasser:	Zhang, Ansheng, Wang, Peina, Ma, Xiaoying, Yin, Xiao, Li, Jiguo, Wang, Haijing, Jiang, Wenkai, Jia, Qian, Ni, Longxing
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine - pharmacology Adenosine Triphosphate - pharmacology Bicuspid - cytology Bicuspid - drug effects Bicuspid - immunology Carrier Proteins - antagonists & inhibitors Carrier Proteins - genetics Carrier Proteins - immunology Caspase 1 - genetics Caspase 1 - immunology Dental Pulp - cytology Dental Pulp - drug effects Dental Pulp - immunology Fibroblasts - cytology Fibroblasts - drug effects Fibroblasts - immunology Gene Expression Regulation Humans I-kappa B Proteins - antagonists & inhibitors I-kappa B Proteins - genetics I-kappa B Proteins - immunology Inflammasomes - drug effects Inflammasomes - immunology Interleukin-1beta - genetics Interleukin-1beta - immunology Lipopolysaccharides - pharmacology Myeloid Differentiation Factor 88 - antagonists & inhibitors Myeloid Differentiation Factor 88 - genetics Myeloid Differentiation Factor 88 - immunology NF-KappaB Inhibitor alpha NLR Family, Pyrin Domain-Containing 3 Protein Peptides - pharmacology Phosphorylation - drug effects Primary Cell Culture Reactive Oxygen Species - immunology Reactive Oxygen Species - metabolism RNA, Small Interfering - genetics RNA, Small Interfering - metabolism Signal Transduction Toll-Like Receptor 4 - genetics Toll-Like Receptor 4 - immunology Tooth Extraction
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