The expression of ATF3, MMP-2 and maspin in tissue chip of glioma

This paper tested and analyzed the expression of ATF3 (activating transcription factor), MMP-2 (matrix metalloprotease) and maspin in tissue chip of glioma and its correlation with glioma advancement. Based on immunohistochemical staining, this paper selected 100 patients with glioma and 13 healthy...

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Veröffentlicht in:Pakistan journal of pharmaceutical sciences 2015-05, Vol.28 (3 Suppl), p.1059-1063
Hauptverfasser: Ma, Siqi, Pang, Changhe, Song, Laijun, Guo, Fuyou, Sun, Hongwei
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container_end_page 1063
container_issue 3 Suppl
container_start_page 1059
container_title Pakistan journal of pharmaceutical sciences
container_volume 28
creator Ma, Siqi
Pang, Changhe
Song, Laijun
Guo, Fuyou
Sun, Hongwei
description This paper tested and analyzed the expression of ATF3 (activating transcription factor), MMP-2 (matrix metalloprotease) and maspin in tissue chip of glioma and its correlation with glioma advancement. Based on immunohistochemical staining, this paper selected 100 patients with glioma and 13 healthy persons to test the relative expression of ATF3, MMP-2 and maspin. The result witnessed 72.0% of ATF3 expression in glioma and 15.4% in healthy brain tissues with P
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Based on immunohistochemical staining, this paper selected 100 patients with glioma and 13 healthy persons to test the relative expression of ATF3, MMP-2 and maspin. The result witnessed 72.0% of ATF3 expression in glioma and 15.4% in healthy brain tissues with P<0.05; glioma had 76.0% of MMP-2 expression while healthy brain tissues only had 7.7% (P<0.05); but maspin expression with 53.0% in glioma was much lower than that with 100% in healthy tissues with P<0.05. If the pathological stage of glioma rose up, the expression of ATF3 and MMP-2 accordingly increased while maspin expression decreased. The correlation between ATF3 expression and MMP-2 expression was positive with r=0.553 and p<0.01; negative correlation between ATF3 expression and maspin expression was found with r=-0.457 and p<0.01; and the expression of MMP-2 and maspin were negatively related with r=-0.551 and p<0.01. According to the above results, it could be concluded that the expression of ATF3, MMP-2 and maspin did relate with each other. Besides, the high expression of ATF3 and MMP-2 as well as the low expression of maspin had great influence on glioma, playing a key role in glioma's occurrence, advancement, invasion and metastasis.]]></description><identifier>ISSN: 1011-601X</identifier><identifier>PMID: 26051724</identifier><language>eng</language><publisher>Pakistan</publisher><subject>Activating Transcription Factor 3 - analysis ; Adolescent ; Adult ; Aged ; Biomarkers, Tumor - analysis ; Brain Neoplasms - enzymology ; Brain Neoplasms - pathology ; Case-Control Studies ; Disease Progression ; Female ; Glioma - enzymology ; Glioma - pathology ; Humans ; Immunohistochemistry ; Male ; Matrix Metalloproteinase 2 - analysis ; Middle Aged ; Neoplasm Invasiveness ; Serpins - analysis ; Tissue Array Analysis ; Young Adult</subject><ispartof>Pakistan journal of pharmaceutical sciences, 2015-05, Vol.28 (3 Suppl), p.1059-1063</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26051724$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ma, Siqi</creatorcontrib><creatorcontrib>Pang, Changhe</creatorcontrib><creatorcontrib>Song, Laijun</creatorcontrib><creatorcontrib>Guo, Fuyou</creatorcontrib><creatorcontrib>Sun, Hongwei</creatorcontrib><title>The expression of ATF3, MMP-2 and maspin in tissue chip of glioma</title><title>Pakistan journal of pharmaceutical sciences</title><addtitle>Pak J Pharm Sci</addtitle><description><![CDATA[This paper tested and analyzed the expression of ATF3 (activating transcription factor), MMP-2 (matrix metalloprotease) and maspin in tissue chip of glioma and its correlation with glioma advancement. Based on immunohistochemical staining, this paper selected 100 patients with glioma and 13 healthy persons to test the relative expression of ATF3, MMP-2 and maspin. The result witnessed 72.0% of ATF3 expression in glioma and 15.4% in healthy brain tissues with P<0.05; glioma had 76.0% of MMP-2 expression while healthy brain tissues only had 7.7% (P<0.05); but maspin expression with 53.0% in glioma was much lower than that with 100% in healthy tissues with P<0.05. If the pathological stage of glioma rose up, the expression of ATF3 and MMP-2 accordingly increased while maspin expression decreased. The correlation between ATF3 expression and MMP-2 expression was positive with r=0.553 and p<0.01; negative correlation between ATF3 expression and maspin expression was found with r=-0.457 and p<0.01; and the expression of MMP-2 and maspin were negatively related with r=-0.551 and p<0.01. According to the above results, it could be concluded that the expression of ATF3, MMP-2 and maspin did relate with each other. Besides, the high expression of ATF3 and MMP-2 as well as the low expression of maspin had great influence on glioma, playing a key role in glioma's occurrence, advancement, invasion and metastasis.]]></description><subject>Activating Transcription Factor 3 - analysis</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Brain Neoplasms - enzymology</subject><subject>Brain Neoplasms - pathology</subject><subject>Case-Control Studies</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Glioma - enzymology</subject><subject>Glioma - pathology</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Male</subject><subject>Matrix Metalloproteinase 2 - analysis</subject><subject>Middle Aged</subject><subject>Neoplasm Invasiveness</subject><subject>Serpins - analysis</subject><subject>Tissue Array Analysis</subject><subject>Young Adult</subject><issn>1011-601X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1j01LxDAYhHNQ3HX1L0iOHizko02aY1lcFXbRQwVvJU3euJGmjU0L-u-tuMLAwMzDwJyhNSWUZoLQtxW6TOmDEJErpS7QiglSUMnyNarqI2D4iiOk5IceDw5X9Y7f4cPhJWNY9xYHnaLv8aLJpzQDNkcff8H3zg9BX6Fzp7sE1yffoNfdfb19zPbPD0_bap9FRumUSaltya2kTjlthXDGgtJUta5gsDTMMs4AGOGlzEstW7MEBXPGCadMy_kG3f7txnH4nCFNTfDJQNfpHoY5NVSUQinBinJBb07o3AawTRx90ON383-b_wBUDVFW</recordid><startdate>201505</startdate><enddate>201505</enddate><creator>Ma, Siqi</creator><creator>Pang, Changhe</creator><creator>Song, Laijun</creator><creator>Guo, Fuyou</creator><creator>Sun, Hongwei</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201505</creationdate><title>The expression of ATF3, MMP-2 and maspin in tissue chip of glioma</title><author>Ma, Siqi ; Pang, Changhe ; Song, Laijun ; Guo, Fuyou ; Sun, Hongwei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p211t-77ad83d71f9fad66fcde9a19bf52ed832d232ee2038748a7bcd2352fcf6f9cb33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Activating Transcription Factor 3 - analysis</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Brain Neoplasms - enzymology</topic><topic>Brain Neoplasms - pathology</topic><topic>Case-Control Studies</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Glioma - enzymology</topic><topic>Glioma - pathology</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Male</topic><topic>Matrix Metalloproteinase 2 - analysis</topic><topic>Middle Aged</topic><topic>Neoplasm Invasiveness</topic><topic>Serpins - analysis</topic><topic>Tissue Array Analysis</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ma, Siqi</creatorcontrib><creatorcontrib>Pang, Changhe</creatorcontrib><creatorcontrib>Song, Laijun</creatorcontrib><creatorcontrib>Guo, Fuyou</creatorcontrib><creatorcontrib>Sun, Hongwei</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Pakistan journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ma, Siqi</au><au>Pang, Changhe</au><au>Song, Laijun</au><au>Guo, Fuyou</au><au>Sun, Hongwei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The expression of ATF3, MMP-2 and maspin in tissue chip of glioma</atitle><jtitle>Pakistan journal of pharmaceutical sciences</jtitle><addtitle>Pak J Pharm Sci</addtitle><date>2015-05</date><risdate>2015</risdate><volume>28</volume><issue>3 Suppl</issue><spage>1059</spage><epage>1063</epage><pages>1059-1063</pages><issn>1011-601X</issn><abstract><![CDATA[This paper tested and analyzed the expression of ATF3 (activating transcription factor), MMP-2 (matrix metalloprotease) and maspin in tissue chip of glioma and its correlation with glioma advancement. Based on immunohistochemical staining, this paper selected 100 patients with glioma and 13 healthy persons to test the relative expression of ATF3, MMP-2 and maspin. The result witnessed 72.0% of ATF3 expression in glioma and 15.4% in healthy brain tissues with P<0.05; glioma had 76.0% of MMP-2 expression while healthy brain tissues only had 7.7% (P<0.05); but maspin expression with 53.0% in glioma was much lower than that with 100% in healthy tissues with P<0.05. If the pathological stage of glioma rose up, the expression of ATF3 and MMP-2 accordingly increased while maspin expression decreased. The correlation between ATF3 expression and MMP-2 expression was positive with r=0.553 and p<0.01; negative correlation between ATF3 expression and maspin expression was found with r=-0.457 and p<0.01; and the expression of MMP-2 and maspin were negatively related with r=-0.551 and p<0.01. According to the above results, it could be concluded that the expression of ATF3, MMP-2 and maspin did relate with each other. Besides, the high expression of ATF3 and MMP-2 as well as the low expression of maspin had great influence on glioma, playing a key role in glioma's occurrence, advancement, invasion and metastasis.]]></abstract><cop>Pakistan</cop><pmid>26051724</pmid><tpages>5</tpages></addata></record>
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subjects Activating Transcription Factor 3 - analysis
Adolescent
Adult
Aged
Biomarkers, Tumor - analysis
Brain Neoplasms - enzymology
Brain Neoplasms - pathology
Case-Control Studies
Disease Progression
Female
Glioma - enzymology
Glioma - pathology
Humans
Immunohistochemistry
Male
Matrix Metalloproteinase 2 - analysis
Middle Aged
Neoplasm Invasiveness
Serpins - analysis
Tissue Array Analysis
Young Adult
title The expression of ATF3, MMP-2 and maspin in tissue chip of glioma
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