Versatile Synthesis of Stable, Functional Polypeptides via Reaction with Epoxides

Methodology was developed for efficient alkylation of methionine residues using epoxides as a general strategy to introduce a wide range of functional groups onto polypeptides. Use of a spacer between epoxide and functional groups further allowed addition of sterically demanding functionalities. Con...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Biomacromolecules 2015-06, Vol.16 (6), p.1802-1806
Hauptverfasser:	Gharakhanian, Eric G, Deming, Timothy J
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylation Epoxy Compounds - chemistry Methionine - chemistry Peptides - chemical synthesis Peptides - chemistry
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!