Kinetics of co-crystal formation with caffeine and citric acid via liquid-assisted grinding analyzed using the distinct element method

[Display omitted] The kinetics of co-crystal formation of caffeine (CF) with citric acid (CTA) was evaluated. Ball milling of CF and CTA in molar ratios of 4:1, 3:1, 2:1, 1:1, 1:2, 1:3, and 1:4 was performed by the liquid-assisted grinding (LAG) method. The samples were characterized by powder X-ray...

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Veröffentlicht in:	European journal of pharmaceutical sciences 2015-08, Vol.76, p.217-224
Hauptverfasser:	Shimono, Keisuke, Kadota, Kazunori, Tozuka, Yuichi, Shimosaka, Atsuko, Shirakawa, Yoshiyuki, Hidaka, Jusuke
Format:	Artikel
Sprache:	eng
Schlagworte:	Caffeine - chemistry Calorimetry, Differential Scanning Chemistry, Pharmaceutical Citric Acid - chemistry Crystallization Crystallography, X-Ray Impact energy Jander equation Kinetics Mechanochemistry Models, Chemical Planetary ball mill Powder Diffraction Spectroscopy, Fourier Transform Infrared Technology, Pharmaceutical - methods
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