Colloidal and antibacterial properties of novel triple-headed, double-tailed amphiphiles: Exploring structure–activity relationships and synergistic mixtures

[Display omitted] Two novel series of tris-cationic, tripled-headed, double-tailed amphiphiles were synthesized and the effects of tail length and head group composition on the critical aggregation concentration (CAC), thermodynamic parameters, and minimum inhibitory concentration (MIC) against six...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2015-07, Vol.23 (13), p.3566-3573
Hauptverfasser:	Marafino, John N., Gallagher, Tara M., Barragan, Jhosdyn, Volkers, Brandi L., LaDow, Jade E., Bonifer, Kyle, Fitzgerald, Gabriel, Floyd, Jason L., McKenna, Kristin, Minahan, Nicholas T., Walsh, Brenna, Seifert, Kyle, Caran, Kevin L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amphiphile Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - pharmacology Antibacterial Bacillus cereus - drug effects Bacillus cereus - growth & development Bacteria Benzene Derivatives - chemical synthesis Benzene Derivatives - pharmacology Bromides - chemistry Cationic amphiphiles Chain length Colloids Critical aggregation concentration Critical micelle concentration Drug Synergism Enterococcus faecalis - drug effects Enterococcus faecalis - growth & development Enthalpy of aggregate formation Enthalpy of micelle formation Entropy of aggregate formation Entropy of micelle formation Escherichia coli - drug effects Escherichia coli - growth & development Flocculation Gram-negative Gram-positive Isothermal titration calorimetry Micelle Microbial Sensitivity Tests Minimum inhibitory concentration Molecular Structure Multi-headed amphiphile Polycephalic amphiphile Pseudomonas aeruginosa - drug effects Pseudomonas aeruginosa - growth & development Quaternary Ammonium Compounds - chemical synthesis Quaternary Ammonium Compounds - chemistry Quaternary Ammonium Compounds - pharmacology Staphylococcus aureus - drug effects Staphylococcus aureus - growth & development Streptococcus agalactiae - drug effects Streptococcus agalactiae - growth & development Structure-Activity Relationship Surface-Active Agents - chemical synthesis Surface-Active Agents - pharmacology Surfactant Synergy Temperature Thermodynamics Thermodynamics of aggregate formation Thermodynamics of micelle formation Tricephalic amphiphile Triple-headed amphiphile
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