Genistein Induces Apoptosis in Immature Human Thymocytes by Inhibiting Topoisomerase-II

The toxicity of genistein, an inhibitor of tyrosine kinases and topoisomerase-II, on human thymocytes was investigated. Genistein induced marked chromatin fragmentation indicative of apoptosis in human thymocyte cultures. Genistein-induced thymocyte apoptosis is unlikely due to an inhibition of basa...

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Veröffentlicht in:	Biochemical and biophysical research communications 1993-07, Vol.194 (2), p.944-950
Hauptverfasser:	Mccabe, M.J., Orrenius, S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Ageing, cell death Apoptosis - drug effects Benzoquinones Biological and medical sciences Cell physiology Cells, Cultured Chromatin - drug effects Chromatin - ultrastructure DNA Damage Etoposide - pharmacology Fundamental and applied biological sciences. Psychology Genistein Humans Immunophenotyping Infant Isoflavones - pharmacology Kinetics Lactams, Macrocyclic Methylprednisolone - pharmacology Molecular and cellular biology Novobiocin - pharmacology Phorbol 12,13-Dibutyrate - pharmacology Protein-Tyrosine Kinases - antagonists & inhibitors Quinones - pharmacology Rifabutin - analogs & derivatives T-Lymphocytes - cytology T-Lymphocytes - drug effects T-Lymphocytes - enzymology Tetradecanoylphorbol Acetate - pharmacology Thymus Gland - cytology Thymus Gland - drug effects Thymus Gland - enzymology Time Factors Topoisomerase II Inhibitors
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