Photoaffinity labeling of the Ah receptor with 3-[3H]methylcholanthrene and formation of a 165-kDa complex between the ligand-binding subunit and a novel cytosolic protein

The aromatic hydrocarbon (Ah) receptor is a cytosolic protein that binds halogenated ligands such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and nonhalogenated ligands such as 3-methylcholanthrene (MC) and benzo[a]pyrene. The best characterized biological response mediated by the Ah receptor is i...

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Veröffentlicht in:	The Journal of biological chemistry 1994-04, Vol.269 (16), p.12129-12136
Hauptverfasser:	de Morais, S M, Giannone, J V, Okey, A B
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Labels - metabolism Animals Cell Line Cytochrome P-450 Enzyme System - biosynthesis Cytosol - metabolism Enzyme Induction Kinetics Liver Neoplasms, Experimental Macromolecular Substances Methylcholanthrene - metabolism Mice Polychlorinated Dibenzodioxins - metabolism Receptors, Aryl Hydrocarbon - isolation & purification Receptors, Aryl Hydrocarbon - metabolism Tritium Tumor Cells, Cultured
Online-Zugang:	Volltext
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