Novel carbon nanohybrids as highly efficient magnetic resonance imaging contrast agents
Novel carbon nanohybrids based on unmodified metallofullerenes have been successfully fabricated for use as a new magnetic resonance imaging （MRI） contrast agent. The nanohybrids showed higher R1 relaxivity and better brightening effect than Gd@C82（OH）x, in Tl-weighted MR images in vivo. This is a r...
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| Veröffentlicht in: | Nano research 2015-04, Vol.8 (4), p.1259-1268 |
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| container_title | Nano research |
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| creator | Cui, Rongli Li, Juan Huang, Huan Zhang, Mingyi Guo, Xihong Chang, Yanan Li, Min Dong, Jinquan Sun, Baoyun Xing, Gengmei |
| description | Novel carbon nanohybrids based on unmodified metallofullerenes have been successfully fabricated for use as a new magnetic resonance imaging （MRI） contrast agent. The nanohybrids showed higher R1 relaxivity and better brightening effect than Gd@C82（OH）x, in Tl-weighted MR images in vivo. This is a result of the proton relaxivity from the original gadofullerenes, which retained a perfect carbon cage structure and so might completely avoid the release of Gd^3＋ ions. A ＂secondary spin-electron transfer＂ relaxation mechanism was proposed to explain how the encaged Gd^3＋ ions of carbon nanohybrids interact with the surrounding water molecules. This approach opens new opportunities for developing highly efficient and low toxicity MRI contrast agents. |
| doi_str_mv | 10.1007/s12274-014-0613-x |
| format | Article |
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The nanohybrids showed higher R1 relaxivity and better brightening effect than Gd@C82（OH）x, in Tl-weighted MR images in vivo. This is a result of the proton relaxivity from the original gadofullerenes, which retained a perfect carbon cage structure and so might completely avoid the release of Gd^3＋ ions. A ＂secondary spin-electron transfer＂ relaxation mechanism was proposed to explain how the encaged Gd^3＋ ions of carbon nanohybrids interact with the surrounding water molecules. This approach opens new opportunities for developing highly efficient and low toxicity MRI contrast agents.</description><identifier>ISSN: 1998-0124</identifier><identifier>EISSN: 1998-0000</identifier><identifier>DOI: 10.1007/s12274-014-0613-x</identifier><language>eng</language><publisher>Beijing: Tsinghua University Press</publisher><subject>Aqueous solutions ; Atomic/Molecular Structure and Spectra ; Biocompatibility ; Biomedical materials ; Biomedicine ; Biotechnology ; Carbon ; Chemistry and Materials Science ; Condensed Matter Physics ; Contrast agents ; Graphene ; Graphite ; High energy physics ; In vivo testing ; Ions ; Magnetic resonance imaging ; Materials Science ; Metallofullerenes ; MRI造影剂 ; Nanomaterials ; Nanostructure ; Nanotechnology ; Research Article ; Toxicity ; 分子相互作用 ; 电子转移 ; 碳 ; 磁共振成像造影剂 ; 笼形结构 ; 高效低毒</subject><ispartof>Nano research, 2015-04, Vol.8 (4), p.1259-1268</ispartof><rights>Tsinghua University Press and Springer-Verlag Berlin Heidelberg 2014</rights><rights>Tsinghua University Press and Springer-Verlag Berlin Heidelberg 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c446t-7cfd7b6d4810e0b53ea0f4e53a32f88f4ba1da22b820c77946825255b47816a33</citedby><cites>FETCH-LOGICAL-c446t-7cfd7b6d4810e0b53ea0f4e53a32f88f4ba1da22b820c77946825255b47816a33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/71233X/71233X.jpg</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12274-014-0613-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12274-014-0613-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids></links><search><creatorcontrib>Cui, Rongli</creatorcontrib><creatorcontrib>Li, Juan</creatorcontrib><creatorcontrib>Huang, Huan</creatorcontrib><creatorcontrib>Zhang, Mingyi</creatorcontrib><creatorcontrib>Guo, Xihong</creatorcontrib><creatorcontrib>Chang, Yanan</creatorcontrib><creatorcontrib>Li, Min</creatorcontrib><creatorcontrib>Dong, Jinquan</creatorcontrib><creatorcontrib>Sun, Baoyun</creatorcontrib><creatorcontrib>Xing, Gengmei</creatorcontrib><title>Novel carbon nanohybrids as highly efficient magnetic resonance imaging contrast agents</title><title>Nano research</title><addtitle>Nano Res</addtitle><addtitle>Nano Research</addtitle><description>Novel carbon nanohybrids based on unmodified metallofullerenes have been successfully fabricated for use as a new magnetic resonance imaging （MRI） contrast agent. The nanohybrids showed higher R1 relaxivity and better brightening effect than Gd@C82（OH）x, in Tl-weighted MR images in vivo. This is a result of the proton relaxivity from the original gadofullerenes, which retained a perfect carbon cage structure and so might completely avoid the release of Gd^3＋ ions. A ＂secondary spin-electron transfer＂ relaxation mechanism was proposed to explain how the encaged Gd^3＋ ions of carbon nanohybrids interact with the surrounding water molecules. This approach opens new opportunities for developing highly efficient and low toxicity MRI contrast agents.</description><subject>Aqueous solutions</subject><subject>Atomic/Molecular Structure and Spectra</subject><subject>Biocompatibility</subject><subject>Biomedical materials</subject><subject>Biomedicine</subject><subject>Biotechnology</subject><subject>Carbon</subject><subject>Chemistry and Materials Science</subject><subject>Condensed Matter Physics</subject><subject>Contrast agents</subject><subject>Graphene</subject><subject>Graphite</subject><subject>High energy physics</subject><subject>In vivo testing</subject><subject>Ions</subject><subject>Magnetic resonance imaging</subject><subject>Materials Science</subject><subject>Metallofullerenes</subject><subject>MRI造影剂</subject><subject>Nanomaterials</subject><subject>Nanostructure</subject><subject>Nanotechnology</subject><subject>Research Article</subject><subject>Toxicity</subject><subject>分子相互作用</subject><subject>电子转移</subject><subject>碳</subject><subject>磁共振成像造影剂</subject><subject>笼形结构</subject><subject>高效低毒</subject><issn>1998-0124</issn><issn>1998-0000</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp9kEtLAzEUhYMoWKs_wF3QjZvRvCbJLEV8QdGN4jJkMplHmSZtMpX235syVcSFgZBL-M659x4AzjG6xgiJm4gJESxDOF2OabY5ABNcFDJD6Rx-15iwY3AS4xwhTjCTE_Dx4j9tD40OpXfQaefbbRm6KkIdYds1bb-Ftq4701k3wIVunB06A4ONPsHGwi79da6Bxrsh6DhA3SQynoKjWvfRnu3fKXh_uH-7e8pmr4_Pd7ezzDDGh0yYuhIlr5jEyKIyp1ajmtmcakpqKWtWalxpQkpJkBGiYFySnOR5yYTEXFM6BVej7zL41drGQS26aGzfa2f9OirMJWdUspwn9PIPOvfr4NJ0iRJCYMaoSBQeKRN8jMHWahnSjmGrMFK7qNUYtUpRq13UapM0ZNTExLrGhl_O_4gu9o1a75pV0v104jxHBWFFQb8ANQ6NAA</recordid><startdate>20150401</startdate><enddate>20150401</enddate><creator>Cui, Rongli</creator><creator>Li, Juan</creator><creator>Huang, Huan</creator><creator>Zhang, 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carbon nanohybrids as highly efficient magnetic resonance imaging contrast agents</title><author>Cui, Rongli ; Li, Juan ; Huang, Huan ; Zhang, Mingyi ; Guo, Xihong ; Chang, Yanan ; Li, Min ; Dong, Jinquan ; Sun, Baoyun ; Xing, Gengmei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c446t-7cfd7b6d4810e0b53ea0f4e53a32f88f4ba1da22b820c77946825255b47816a33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aqueous solutions</topic><topic>Atomic/Molecular Structure and Spectra</topic><topic>Biocompatibility</topic><topic>Biomedical materials</topic><topic>Biomedicine</topic><topic>Biotechnology</topic><topic>Carbon</topic><topic>Chemistry and Materials Science</topic><topic>Condensed Matter Physics</topic><topic>Contrast agents</topic><topic>Graphene</topic><topic>Graphite</topic><topic>High energy physics</topic><topic>In vivo testing</topic><topic>Ions</topic><topic>Magnetic 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Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cui, Rongli</au><au>Li, Juan</au><au>Huang, Huan</au><au>Zhang, Mingyi</au><au>Guo, Xihong</au><au>Chang, Yanan</au><au>Li, Min</au><au>Dong, Jinquan</au><au>Sun, Baoyun</au><au>Xing, Gengmei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Novel carbon nanohybrids as highly efficient magnetic resonance imaging contrast agents</atitle><jtitle>Nano research</jtitle><stitle>Nano Res</stitle><addtitle>Nano Research</addtitle><date>2015-04-01</date><risdate>2015</risdate><volume>8</volume><issue>4</issue><spage>1259</spage><epage>1268</epage><pages>1259-1268</pages><issn>1998-0124</issn><eissn>1998-0000</eissn><abstract>Novel carbon nanohybrids based on unmodified metallofullerenes have been successfully fabricated for use as a new magnetic resonance imaging （MRI） contrast agent. The nanohybrids showed higher R1 relaxivity and better brightening effect than Gd@C82（OH）x, in Tl-weighted MR images in vivo. This is a result of the proton relaxivity from the original gadofullerenes, which retained a perfect carbon cage structure and so might completely avoid the release of Gd^3＋ ions. A ＂secondary spin-electron transfer＂ relaxation mechanism was proposed to explain how the encaged Gd^3＋ ions of carbon nanohybrids interact with the surrounding water molecules. This approach opens new opportunities for developing highly efficient and low toxicity MRI contrast agents.</abstract><cop>Beijing</cop><pub>Tsinghua University Press</pub><doi>10.1007/s12274-014-0613-x</doi><tpages>10</tpages></addata></record> |
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| identifier | ISSN: 1998-0124 |
| ispartof | Nano research, 2015-04, Vol.8 (4), p.1259-1268 |
| issn | 1998-0124 1998-0000 |
| language | eng |
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| subjects | Aqueous solutions Atomic/Molecular Structure and Spectra Biocompatibility Biomedical materials Biomedicine Biotechnology Carbon Chemistry and Materials Science Condensed Matter Physics Contrast agents Graphene Graphite High energy physics In vivo testing Ions Magnetic resonance imaging Materials Science Metallofullerenes MRI造影剂 Nanomaterials Nanostructure Nanotechnology Research Article Toxicity 分子相互作用 电子转移 碳 磁共振成像造影剂 笼形结构 高效低毒 |
| title | Novel carbon nanohybrids as highly efficient magnetic resonance imaging contrast agents |
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