Hydroxyalkylation-Initiated Radical Cyclization of N‑Allylbenzamide for Direct Construction of Isoquinolinone

A metal-free hydroxyalkylation-initiated radical six-membered heterocycle formation reaction of N-allylbenzamide is developed. This reaction proceeds through C­(sp3)–H bond cleavage, oxyalkylation of the double bond, and intramolecular cyclization, which provides a new route toward 4-substituted 3,4...

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Veröffentlicht in:	Organic letters 2015-06, Vol.17 (11), p.2724-2727
Hauptverfasser:	Zhou, Wei, Ni, Shengyang, Mei, Haibo, Han, Jianlin, Pan, Yi
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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