Hydroxyalkylation-Initiated Radical Cyclization of N‑Allylbenzamide for Direct Construction of Isoquinolinone

Hydroxyalkylation-Initiated Radical Cyclization of N‑Allylbenzamide for Direct Construction of Isoquinolinone

A metal-free hydroxyalkylation-initiated radical six-membered heterocycle formation reaction of N-allylbenzamide is developed. This reaction proceeds through C­(sp3)–H bond cleavage, oxyalkylation of the double bond, and intramolecular cyclization, which provides a new route toward 4-substituted 3,4...

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Veröffentlicht in:Organic letters 2015-06, Vol.17 (11), p.2724-2727
Hauptverfasser: Zhou, Wei, Ni, Shengyang, Mei, Haibo, Han, Jianlin, Pan, Yi
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container_issue 11
container_start_page 2724
container_title Organic letters
container_volume 17
creator Zhou, Wei
Ni, Shengyang
Mei, Haibo
Han, Jianlin
Pan, Yi
description A metal-free hydroxyalkylation-initiated radical six-membered heterocycle formation reaction of N-allylbenzamide is developed. This reaction proceeds through C­(sp3)–H bond cleavage, oxyalkylation of the double bond, and intramolecular cyclization, which provides a new route toward 4-substituted 3,4-dihydroisoquinolin-1­(2H)-one derivatives.
doi_str_mv 10.1021/acs.orglett.5b01140
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title Hydroxyalkylation-Initiated Radical Cyclization of N‑Allylbenzamide for Direct Construction of Isoquinolinone
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