Examining the neuroprotective effects of protocatechuic acid and chrysin on in vitro and in vivo models of Parkinson disease

Polypharmacology-based strategies using drug combinations with different mechanisms of action are gaining increasing attention as a novel methodology to discover potentially innovative medicines for neurodegenerative disorders. We used this approach to examine the combined neuroprotective effects of...

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Veröffentlicht in:	Free radical biology & medicine 2015-07, Vol.84, p.331-343
Hauptverfasser:	Zhang, Zaijun, Li, Guohui, Szeto, Samuel S.W., Chong, Cheong Meng, Quan, Quan, Huang, Chen, Cui, Wei, Guo, Baojian, Wang, Yuqiang, Han, Yifan, Michael Siu, K.W., Yuen Lee, Simon Ming, Chu, Ivan K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-inflammation Antiparkinson Agents - pharmacology Antiparkinson Agents - therapeutic use Dopaminergic Neurons - drug effects Dopaminergic Neurons - physiology Drug Evaluation, Preclinical Flavonoids - pharmacology Flavonoids - therapeutic use Free radicals Heme Oxygenase-1 - metabolism Hydroxybenzoates - pharmacology Hydroxybenzoates - therapeutic use Neuroprotection Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use NF-E2-Related Factor 2 - metabolism NF-κB Nitric Oxide - metabolism Nitric Oxide Synthase Type II - metabolism NRF2 Oxidative Stress Parkinson disease Parkinson Disease - drug therapy PC12 Cells Proteome - metabolism Proteomics Rats Transcription Factor RelA - metabolism Zebrafish
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