Lycopene inhibits cyclic strain-induced endothelin-1 expression through the suppression of reactive oxygen species generation and induction of heme oxygenase-1 in human umbilical vein endothelial cells

Summary Lycopene is the most potent active antioxidant among the major carotenoids, and its use has been associated with a reduced risk for cardiovascular disease (CVD). Endothelin‐1 (ET‐1) is a powerful vasopressor synthesized by endothelial cells and plays a crucial role in the pathophysiology of...

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