Calcitonin gene-related peptide cooperates with substance P to inhibit melanogenesis and induces apoptosis of B16F10 cells

•CGRP makes no effect on tyrosinase activity and melanin synthesis.•CGRP cooperates with SP to inhibit melanogenesis.•CGRP up-regulates its receptor components expression in B16F10 cells.•CGRP improved NK-1R expression.•CGRP shows pro-apoptotic impact on B16F10 cells. Skin is the largest organ in hu...

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Veröffentlicht in:	Cytokine (Philadelphia, Pa.) Pa.), 2015-07, Vol.74 (1), p.137-144
Hauptverfasser:	Zhou, Jia, Feng, Jun-Yi, Wang, Qian, Shang, Jing
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects B16F10 cells bcl-2-Associated X Protein - genetics Calcitonin Gene-Related Peptide - pharmacology Caspases - classification Caspases - genetics Cell Line, Tumor CGRP Epidermis - cytology Epidermis - metabolism Melanins - antagonists & inhibitors Melanins - biosynthesis Melanocytes - drug effects Melanocytes - physiology Mice Monophenol Monooxygenase NK-1R Pro-apoptotic impact Substance P Up-Regulation
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