Monitoring glutamate levels in the posterior cingulate cortex of thyroid dysfunction patients with TE-averaged PRESS at 3T

Patients with thyroid dysfunction frequently have neuropsychiatric complaints such as lack of concentration, poor memory, depression, anxiety and mania, which suggest brain dysfunction. However, the underlying process of this dysfunction remains unclear. Recent studies of the glutamatergic system ha...

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Veröffentlicht in:Magnetic resonance imaging 2015-07, Vol.33 (6), p.774-778
Hauptverfasser: Zhang, Qiujuan, Bai, Zhilan, Gong, Yan, Liu, Xinxin, Dai, Xiaoqing, Wang, Shejiao, Liu, Feng
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container_end_page 778
container_issue 6
container_start_page 774
container_title Magnetic resonance imaging
container_volume 33
creator Zhang, Qiujuan
Bai, Zhilan
Gong, Yan
Liu, Xinxin
Dai, Xiaoqing
Wang, Shejiao
Liu, Feng
description Patients with thyroid dysfunction frequently have neuropsychiatric complaints such as lack of concentration, poor memory, depression, anxiety and mania, which suggest brain dysfunction. However, the underlying process of this dysfunction remains unclear. Recent studies of the glutamatergic system have offered important insight into the neuropsychiatric process. Thus, this study investigates changes in glutamate concentration in patients with thyroid dysfunction. It also clarifies whether Glu levels are related to thyroid hormones via proton magnetic resonance spectroscopy. 36 untreated patients with thyroid dysfunction (18 hyperthyroidism patients and 18 hypothyroidism patients) and 18 age- and gender-matched controls were included in this study. The posterior cingulate cortex was examined by MRS with TE-averaged PRESS at 3T. The intensity of glutamate, choline, N-acetylaspartate, and creatine was assessed using jMRUI v4.0 software. We found a significant difference among hyper-/hypo- and control groups in Glu (P=0.003) and Cho (P=0.015). The concentrations of glutamate increased (P=0.006) in the posterior cingulate cortex in patients with hypothyroidism and significantly decreased (P=0.002) in hyperthyroidism patients relative to controls. There were no difference in the concentrations of choline between hyperthyroidism patients and controls (P=0.679). Versus the hyperthyroidism group, the hypothyroidism group showed increased glutamate (P=0.018) and choline (P=0.001) in the posterior cingulate cortex. There was no significant difference in the concentrations of NAA or creatine across the three groups (P>0.05). The Glu level correlates with TT3 (P=0.000) and FT3 (P=0.022). The signal intensity of glutamate shows significant differences in the region of the posterior cingulate cortex in patients with thyroid dysfunction. This change indicates a potential role of glutamate in the brain dysfunction experience by patients with thyroid hormone disorders.
doi_str_mv 10.1016/j.mri.2015.03.004
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However, the underlying process of this dysfunction remains unclear. Recent studies of the glutamatergic system have offered important insight into the neuropsychiatric process. Thus, this study investigates changes in glutamate concentration in patients with thyroid dysfunction. It also clarifies whether Glu levels are related to thyroid hormones via proton magnetic resonance spectroscopy. 36 untreated patients with thyroid dysfunction (18 hyperthyroidism patients and 18 hypothyroidism patients) and 18 age- and gender-matched controls were included in this study. The posterior cingulate cortex was examined by MRS with TE-averaged PRESS at 3T. The intensity of glutamate, choline, N-acetylaspartate, and creatine was assessed using jMRUI v4.0 software. We found a significant difference among hyper-/hypo- and control groups in Glu (P=0.003) and Cho (P=0.015). The concentrations of glutamate increased (P=0.006) in the posterior cingulate cortex in patients with hypothyroidism and significantly decreased (P=0.002) in hyperthyroidism patients relative to controls. There were no difference in the concentrations of choline between hyperthyroidism patients and controls (P=0.679). Versus the hyperthyroidism group, the hypothyroidism group showed increased glutamate (P=0.018) and choline (P=0.001) in the posterior cingulate cortex. There was no significant difference in the concentrations of NAA or creatine across the three groups (P&gt;0.05). The Glu level correlates with TT3 (P=0.000) and FT3 (P=0.022). The signal intensity of glutamate shows significant differences in the region of the posterior cingulate cortex in patients with thyroid dysfunction. 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The concentrations of glutamate increased (P=0.006) in the posterior cingulate cortex in patients with hypothyroidism and significantly decreased (P=0.002) in hyperthyroidism patients relative to controls. There were no difference in the concentrations of choline between hyperthyroidism patients and controls (P=0.679). Versus the hyperthyroidism group, the hypothyroidism group showed increased glutamate (P=0.018) and choline (P=0.001) in the posterior cingulate cortex. There was no significant difference in the concentrations of NAA or creatine across the three groups (P&gt;0.05). The Glu level correlates with TT3 (P=0.000) and FT3 (P=0.022). The signal intensity of glutamate shows significant differences in the region of the posterior cingulate cortex in patients with thyroid dysfunction. This change indicates a potential role of glutamate in the brain dysfunction experience by patients with thyroid hormone disorders.</description><subject>Adult</subject><subject>Aspartic Acid - analogs &amp; derivatives</subject><subject>Aspartic Acid - metabolism</subject><subject>Choline - metabolism</subject><subject>Creatine - metabolism</subject><subject>Female</subject><subject>Glutamate</subject><subject>Glutamic Acid - metabolism</subject><subject>Gyrus Cinguli - metabolism</subject><subject>Humans</subject><subject>Hyperthyroidism</subject><subject>Hypothyroidism</subject><subject>Magnetic resonance spectroscopy</subject><subject>Male</subject><subject>Proton Magnetic Resonance Spectroscopy</subject><subject>TE-averaged PRESS</subject><subject>Thyroid Diseases - metabolism</subject><subject>Thyroid dysfunction</subject><subject>Thyroid Gland - metabolism</subject><issn>0730-725X</issn><issn>1873-5894</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90M1uEzEUhmELgWgoXAAb5CWbGY7teH7EClUpILUqokFiZ3nsM6mjmXGwPWnD1eMopcuuzuY53-Il5D2DkgGrPm3LMbiSA5MliBJg-YIsWFOLQjbt8iVZQC2gqLn8fUbexLgFAMmFfE3OuGxkU3G-IH-v_eSSD27a0M0wJz3qhHTAPQ6RuommO6Q7HxMG5wM1mc3DURgfEj5Q32dxCN5Zag-xnyeTnJ_oTieHU4r03qU7ul4Veo9Bb9DSHz9Xt7dUJyrWb8mrXg8R3z3ec_LrcrW--FZc3Xz9fvHlqjBCNKkwVW04aI5tgwidZT3aumLSGNkLK6zVjWbLxnSy6wRvQWphW9Nhjxxa3TNxTj6ednfB_5kxJjW6aHAY9IR-jopVTbVksgWRKTtRE3yMAXu1C27U4aAYqGNytVU5uTomVyBUTp5_PjzOz92I9unjf-MMPp9ATop7h0FFk-sYtC6gScp698z8PySilLE</recordid><startdate>20150701</startdate><enddate>20150701</enddate><creator>Zhang, Qiujuan</creator><creator>Bai, Zhilan</creator><creator>Gong, Yan</creator><creator>Liu, Xinxin</creator><creator>Dai, Xiaoqing</creator><creator>Wang, Shejiao</creator><creator>Liu, Feng</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150701</creationdate><title>Monitoring glutamate levels in the posterior cingulate cortex of thyroid dysfunction patients with TE-averaged PRESS at 3T</title><author>Zhang, Qiujuan ; Bai, Zhilan ; Gong, Yan ; Liu, Xinxin ; Dai, Xiaoqing ; Wang, Shejiao ; Liu, Feng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c338t-c67c20a2e98ee0bd1fed7615cc5f3d3dda8a148cb5bb32905a3d9cbefe209af13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Aspartic Acid - analogs &amp; derivatives</topic><topic>Aspartic Acid - metabolism</topic><topic>Choline - metabolism</topic><topic>Creatine - metabolism</topic><topic>Female</topic><topic>Glutamate</topic><topic>Glutamic Acid - metabolism</topic><topic>Gyrus Cinguli - metabolism</topic><topic>Humans</topic><topic>Hyperthyroidism</topic><topic>Hypothyroidism</topic><topic>Magnetic resonance spectroscopy</topic><topic>Male</topic><topic>Proton Magnetic Resonance Spectroscopy</topic><topic>TE-averaged PRESS</topic><topic>Thyroid Diseases - metabolism</topic><topic>Thyroid dysfunction</topic><topic>Thyroid Gland - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Qiujuan</creatorcontrib><creatorcontrib>Bai, Zhilan</creatorcontrib><creatorcontrib>Gong, Yan</creatorcontrib><creatorcontrib>Liu, Xinxin</creatorcontrib><creatorcontrib>Dai, Xiaoqing</creatorcontrib><creatorcontrib>Wang, Shejiao</creatorcontrib><creatorcontrib>Liu, Feng</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Magnetic resonance imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Qiujuan</au><au>Bai, Zhilan</au><au>Gong, Yan</au><au>Liu, Xinxin</au><au>Dai, Xiaoqing</au><au>Wang, Shejiao</au><au>Liu, Feng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Monitoring glutamate levels in the posterior cingulate cortex of thyroid dysfunction patients with TE-averaged PRESS at 3T</atitle><jtitle>Magnetic resonance imaging</jtitle><addtitle>Magn Reson Imaging</addtitle><date>2015-07-01</date><risdate>2015</risdate><volume>33</volume><issue>6</issue><spage>774</spage><epage>778</epage><pages>774-778</pages><issn>0730-725X</issn><eissn>1873-5894</eissn><abstract>Patients with thyroid dysfunction frequently have neuropsychiatric complaints such as lack of concentration, poor memory, depression, anxiety and mania, which suggest brain dysfunction. However, the underlying process of this dysfunction remains unclear. Recent studies of the glutamatergic system have offered important insight into the neuropsychiatric process. Thus, this study investigates changes in glutamate concentration in patients with thyroid dysfunction. It also clarifies whether Glu levels are related to thyroid hormones via proton magnetic resonance spectroscopy. 36 untreated patients with thyroid dysfunction (18 hyperthyroidism patients and 18 hypothyroidism patients) and 18 age- and gender-matched controls were included in this study. The posterior cingulate cortex was examined by MRS with TE-averaged PRESS at 3T. The intensity of glutamate, choline, N-acetylaspartate, and creatine was assessed using jMRUI v4.0 software. We found a significant difference among hyper-/hypo- and control groups in Glu (P=0.003) and Cho (P=0.015). The concentrations of glutamate increased (P=0.006) in the posterior cingulate cortex in patients with hypothyroidism and significantly decreased (P=0.002) in hyperthyroidism patients relative to controls. There were no difference in the concentrations of choline between hyperthyroidism patients and controls (P=0.679). Versus the hyperthyroidism group, the hypothyroidism group showed increased glutamate (P=0.018) and choline (P=0.001) in the posterior cingulate cortex. There was no significant difference in the concentrations of NAA or creatine across the three groups (P&gt;0.05). The Glu level correlates with TT3 (P=0.000) and FT3 (P=0.022). The signal intensity of glutamate shows significant differences in the region of the posterior cingulate cortex in patients with thyroid dysfunction. This change indicates a potential role of glutamate in the brain dysfunction experience by patients with thyroid hormone disorders.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>25858622</pmid><doi>10.1016/j.mri.2015.03.004</doi><tpages>5</tpages></addata></record>
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subjects Adult
Aspartic Acid - analogs & derivatives
Aspartic Acid - metabolism
Choline - metabolism
Creatine - metabolism
Female
Glutamate
Glutamic Acid - metabolism
Gyrus Cinguli - metabolism
Humans
Hyperthyroidism
Hypothyroidism
Magnetic resonance spectroscopy
Male
Proton Magnetic Resonance Spectroscopy
TE-averaged PRESS
Thyroid Diseases - metabolism
Thyroid dysfunction
Thyroid Gland - metabolism
title Monitoring glutamate levels in the posterior cingulate cortex of thyroid dysfunction patients with TE-averaged PRESS at 3T
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