A doxycycline-loaded polymer-lipid encapsulation matrix coating for the prevention of implant-related osteomyelitis due to doxycycline-resistant methicillin-resistant Staphylococcus aureus

Implant-associated bone infections caused by antibiotic-resistant pathogens pose significant clinical challenges to treating physicians. Prophylactic strategies that act against resistant organisms, such as methicillin-resistant Staphylococcus aureus (MRSA), are urgently required. In the present stu...

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Veröffentlicht in:	Journal of controlled release 2015-07, Vol.209, p.47-56
Hauptverfasser:	Metsemakers, Willem-Jan, Emanuel, Noam, Cohen, Or, Reichart, Malka, Potapova, Inga, Schmid, Tanja, Segal, David, Riool, Martijn, Kwakman, Paulus H S, de Boer, Leonie, de Breij, Anna, Nibbering, Peter H, Richards, R Geoff, Zaat, Sebastian A J, Moriarty, T Fintan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - therapeutic use Doxycycline - administration & dosage Doxycycline - chemistry Doxycycline - therapeutic use Drug Liberation Drug Resistance, Bacterial Female Lipids - chemistry Methicillin-Resistant Staphylococcus aureus Mice, Inbred C57BL Osteomyelitis - prevention & control Polymers - chemistry Prostheses and Implants Rabbits Staphylococcal Infections - prevention & control Titanium
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