The Relationship Between Variation in Size of the Primordial Follicle Pool and Age at Natural Menopause
Context: Menopause has been hypothesized to occur when the nongrowing follicle (NGF) number falls below a critical threshold. Age at natural menopause can be predicted using NGF numbers and this threshold. These predictions support the use of ovarian reserve tests, reflective of the ovarian follicle...
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| Veröffentlicht in: | The journal of clinical endocrinology and metabolism 2015-06, Vol.100 (6), p.E845-E851 |
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| container_issue | 6 |
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| container_title | The journal of clinical endocrinology and metabolism |
| container_volume | 100 |
| creator | Depmann, M Faddy, M. J van der Schouw, Y. T Peeters, P. H. M Broer, S. L Kelsey, T. W Nelson, S. M Broekmans, F. J. M |
| description | Context:
Menopause has been hypothesized to occur when the nongrowing follicle (NGF) number falls below a critical threshold. Age at natural menopause can be predicted using NGF numbers and this threshold. These predictions support the use of ovarian reserve tests, reflective of the ovarian follicle pool, in menopause forecasting.
Objective:
The objective of the study was to investigate the hypothesis that age-specific NGF numbers reflect age at natural menopause.
Design and Setting:
Histologically derived NGF numbers obtained from published literature (n = 218) and distribution of menopausal ages derived from the population-based Prospect-European Prospective Investigation into Cancer and Nutrition (Prospect-EPIC) cohort (n = 4037) were combined.
Participants:
NGF data were from single ovaries that had been obtained postnatally for various reasons, such as elective surgery or autopsy. From the Prospect-EPIC cohort, women aged 58 years and older with a known age at natural menopause were selected.
Interventions:
There were no interventions.
Main Outcome Measure(s):
Conformity between observed age at menopause in the Prospect-EPIC cohort and NGF-predicted age at menopause from a model for age-related NGF decline constructed using a robust regression analysis. A critical threshold for NGF number was estimated by comparing the probability distribution of the age at which the NGF numbers fall below this threshold with the observed distribution of age at natural menopause from the Prospect-EPIC cohort.
Results:
The distributions of observed age at natural menopause and predicted age at natural menopause showed close conformity.
Conclusion:
The close conformity observed between NGF-predicted and actual age at natural menopause supports the hypothesis that that the size of the primordial follicle pool is an important determinant for the length of the individual ovarian life span and supports the concept of menopause prediction using ovarian reserve tests, such as anti-Müllerian hormone and antral follicle count, as derivatives of the true ovarian reserve. |
| doi_str_mv | 10.1210/jc.2015-1298 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1686414640</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1686414640</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4840-d0f12acb8ae7a5a7bba4c6da5472311482ed9cd2617835c55e952a8cccf0cefe3</originalsourceid><addsrcrecordid>eNptkEFv1DAQRi0Eokvhxhn5yIG0tmPHybFUFJBaQFAQN2vWmXS9eO3UTrQqvx6HLZxqybJm9Pxp5hHykrMTLjg73doTwbiquOjaR2TFO6kqzTv9mKwYE7zqtPh5RJ7lvGWMS6nqp-RIqI4r1egVubneIP2KHiYXQ964kb7FaY8Y6A9I7m-XukC_ud9I40CnQn9JbhdT78DTi-i9s770YvQUQk_PbpDCRD_BNKcCXGGII8wZn5MnA_iML-7fY_L94t31-Yfq8vP7j-dnl5WVrWRVzwYuwK5bQA0K9HoN0jY9KKlFzblsBfad7UXDdVsrqxR2SkBrrR2YxQHrY_L6kDumeDtjnszOZYveQ8A4Z8ObtpFcNpIV9M0BtSnmnHAwY9kM0p3hzCxqzdaaRa1Z1Bb81X3yvN5h_x_-57IA8gDso58w5V9-3mMyGwQ_bQwrRza6rZZE1pSqKlctY9SHbxj6aJMLOCbM2WzjnEJR9fA0fwAKbZV7</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1686414640</pqid></control><display><type>article</type><title>The Relationship Between Variation in Size of the Primordial Follicle Pool and Age at Natural Menopause</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><source>Journals@Ovid Complete</source><creator>Depmann, M ; Faddy, M. J ; van der Schouw, Y. T ; Peeters, P. H. M ; Broer, S. L ; Kelsey, T. W ; Nelson, S. M ; Broekmans, F. J. M</creator><creatorcontrib>Depmann, M ; Faddy, M. J ; van der Schouw, Y. T ; Peeters, P. H. M ; Broer, S. L ; Kelsey, T. W ; Nelson, S. M ; Broekmans, F. J. M</creatorcontrib><description>Context:
Menopause has been hypothesized to occur when the nongrowing follicle (NGF) number falls below a critical threshold. Age at natural menopause can be predicted using NGF numbers and this threshold. These predictions support the use of ovarian reserve tests, reflective of the ovarian follicle pool, in menopause forecasting.
Objective:
The objective of the study was to investigate the hypothesis that age-specific NGF numbers reflect age at natural menopause.
Design and Setting:
Histologically derived NGF numbers obtained from published literature (n = 218) and distribution of menopausal ages derived from the population-based Prospect-European Prospective Investigation into Cancer and Nutrition (Prospect-EPIC) cohort (n = 4037) were combined.
Participants:
NGF data were from single ovaries that had been obtained postnatally for various reasons, such as elective surgery or autopsy. From the Prospect-EPIC cohort, women aged 58 years and older with a known age at natural menopause were selected.
Interventions:
There were no interventions.
Main Outcome Measure(s):
Conformity between observed age at menopause in the Prospect-EPIC cohort and NGF-predicted age at menopause from a model for age-related NGF decline constructed using a robust regression analysis. A critical threshold for NGF number was estimated by comparing the probability distribution of the age at which the NGF numbers fall below this threshold with the observed distribution of age at natural menopause from the Prospect-EPIC cohort.
Results:
The distributions of observed age at natural menopause and predicted age at natural menopause showed close conformity.
Conclusion:
The close conformity observed between NGF-predicted and actual age at natural menopause supports the hypothesis that that the size of the primordial follicle pool is an important determinant for the length of the individual ovarian life span and supports the concept of menopause prediction using ovarian reserve tests, such as anti-Müllerian hormone and antral follicle count, as derivatives of the true ovarian reserve.</description><identifier>ISSN: 0021-972X</identifier><identifier>EISSN: 1945-7197</identifier><identifier>DOI: 10.1210/jc.2015-1298</identifier><identifier>PMID: 25915567</identifier><language>eng</language><publisher>United States: Endocrine Society</publisher><subject>Adolescent ; Adult ; Age Factors ; Aging - physiology ; Cell Size ; Child ; Child, Preschool ; Female ; Humans ; Infant ; Infant, Newborn ; Menopause - physiology ; Middle Aged ; Ovarian Follicle - cytology ; Ovarian Reserve - physiology ; Ovary - cytology ; Pregnancy ; Young Adult</subject><ispartof>The journal of clinical endocrinology and metabolism, 2015-06, Vol.100 (6), p.E845-E851</ispartof><rights>Copyright © 2015 by the Endocrine Society</rights><rights>Copyright © 2015 by The Endocrine Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4840-d0f12acb8ae7a5a7bba4c6da5472311482ed9cd2617835c55e952a8cccf0cefe3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25915567$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Depmann, M</creatorcontrib><creatorcontrib>Faddy, M. J</creatorcontrib><creatorcontrib>van der Schouw, Y. T</creatorcontrib><creatorcontrib>Peeters, P. H. M</creatorcontrib><creatorcontrib>Broer, S. L</creatorcontrib><creatorcontrib>Kelsey, T. W</creatorcontrib><creatorcontrib>Nelson, S. M</creatorcontrib><creatorcontrib>Broekmans, F. J. M</creatorcontrib><title>The Relationship Between Variation in Size of the Primordial Follicle Pool and Age at Natural Menopause</title><title>The journal of clinical endocrinology and metabolism</title><addtitle>J Clin Endocrinol Metab</addtitle><description>Context:
Menopause has been hypothesized to occur when the nongrowing follicle (NGF) number falls below a critical threshold. Age at natural menopause can be predicted using NGF numbers and this threshold. These predictions support the use of ovarian reserve tests, reflective of the ovarian follicle pool, in menopause forecasting.
Objective:
The objective of the study was to investigate the hypothesis that age-specific NGF numbers reflect age at natural menopause.
Design and Setting:
Histologically derived NGF numbers obtained from published literature (n = 218) and distribution of menopausal ages derived from the population-based Prospect-European Prospective Investigation into Cancer and Nutrition (Prospect-EPIC) cohort (n = 4037) were combined.
Participants:
NGF data were from single ovaries that had been obtained postnatally for various reasons, such as elective surgery or autopsy. From the Prospect-EPIC cohort, women aged 58 years and older with a known age at natural menopause were selected.
Interventions:
There were no interventions.
Main Outcome Measure(s):
Conformity between observed age at menopause in the Prospect-EPIC cohort and NGF-predicted age at menopause from a model for age-related NGF decline constructed using a robust regression analysis. A critical threshold for NGF number was estimated by comparing the probability distribution of the age at which the NGF numbers fall below this threshold with the observed distribution of age at natural menopause from the Prospect-EPIC cohort.
Results:
The distributions of observed age at natural menopause and predicted age at natural menopause showed close conformity.
Conclusion:
The close conformity observed between NGF-predicted and actual age at natural menopause supports the hypothesis that that the size of the primordial follicle pool is an important determinant for the length of the individual ovarian life span and supports the concept of menopause prediction using ovarian reserve tests, such as anti-Müllerian hormone and antral follicle count, as derivatives of the true ovarian reserve.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Aging - physiology</subject><subject>Cell Size</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Menopause - physiology</subject><subject>Middle Aged</subject><subject>Ovarian Follicle - cytology</subject><subject>Ovarian Reserve - physiology</subject><subject>Ovary - cytology</subject><subject>Pregnancy</subject><subject>Young Adult</subject><issn>0021-972X</issn><issn>1945-7197</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkEFv1DAQRi0Eokvhxhn5yIG0tmPHybFUFJBaQFAQN2vWmXS9eO3UTrQqvx6HLZxqybJm9Pxp5hHykrMTLjg73doTwbiquOjaR2TFO6kqzTv9mKwYE7zqtPh5RJ7lvGWMS6nqp-RIqI4r1egVubneIP2KHiYXQ964kb7FaY8Y6A9I7m-XukC_ud9I40CnQn9JbhdT78DTi-i9s770YvQUQk_PbpDCRD_BNKcCXGGII8wZn5MnA_iML-7fY_L94t31-Yfq8vP7j-dnl5WVrWRVzwYuwK5bQA0K9HoN0jY9KKlFzblsBfad7UXDdVsrqxR2SkBrrR2YxQHrY_L6kDumeDtjnszOZYveQ8A4Z8ObtpFcNpIV9M0BtSnmnHAwY9kM0p3hzCxqzdaaRa1Z1Bb81X3yvN5h_x_-57IA8gDso58w5V9-3mMyGwQ_bQwrRza6rZZE1pSqKlctY9SHbxj6aJMLOCbM2WzjnEJR9fA0fwAKbZV7</recordid><startdate>201506</startdate><enddate>201506</enddate><creator>Depmann, M</creator><creator>Faddy, M. J</creator><creator>van der Schouw, Y. T</creator><creator>Peeters, P. H. M</creator><creator>Broer, S. L</creator><creator>Kelsey, T. W</creator><creator>Nelson, S. M</creator><creator>Broekmans, F. J. M</creator><general>Endocrine Society</general><general>Copyright by The Endocrine Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201506</creationdate><title>The Relationship Between Variation in Size of the Primordial Follicle Pool and Age at Natural Menopause</title><author>Depmann, M ; Faddy, M. J ; van der Schouw, Y. T ; Peeters, P. H. M ; Broer, S. L ; Kelsey, T. W ; Nelson, S. M ; Broekmans, F. J. M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4840-d0f12acb8ae7a5a7bba4c6da5472311482ed9cd2617835c55e952a8cccf0cefe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Aging - physiology</topic><topic>Cell Size</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Female</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Menopause - physiology</topic><topic>Middle Aged</topic><topic>Ovarian Follicle - cytology</topic><topic>Ovarian Reserve - physiology</topic><topic>Ovary - cytology</topic><topic>Pregnancy</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Depmann, M</creatorcontrib><creatorcontrib>Faddy, M. J</creatorcontrib><creatorcontrib>van der Schouw, Y. T</creatorcontrib><creatorcontrib>Peeters, P. H. M</creatorcontrib><creatorcontrib>Broer, S. L</creatorcontrib><creatorcontrib>Kelsey, T. W</creatorcontrib><creatorcontrib>Nelson, S. M</creatorcontrib><creatorcontrib>Broekmans, F. J. M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of clinical endocrinology and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Depmann, M</au><au>Faddy, M. J</au><au>van der Schouw, Y. T</au><au>Peeters, P. H. M</au><au>Broer, S. L</au><au>Kelsey, T. W</au><au>Nelson, S. M</au><au>Broekmans, F. J. M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Relationship Between Variation in Size of the Primordial Follicle Pool and Age at Natural Menopause</atitle><jtitle>The journal of clinical endocrinology and metabolism</jtitle><addtitle>J Clin Endocrinol Metab</addtitle><date>2015-06</date><risdate>2015</risdate><volume>100</volume><issue>6</issue><spage>E845</spage><epage>E851</epage><pages>E845-E851</pages><issn>0021-972X</issn><eissn>1945-7197</eissn><abstract>Context:
Menopause has been hypothesized to occur when the nongrowing follicle (NGF) number falls below a critical threshold. Age at natural menopause can be predicted using NGF numbers and this threshold. These predictions support the use of ovarian reserve tests, reflective of the ovarian follicle pool, in menopause forecasting.
Objective:
The objective of the study was to investigate the hypothesis that age-specific NGF numbers reflect age at natural menopause.
Design and Setting:
Histologically derived NGF numbers obtained from published literature (n = 218) and distribution of menopausal ages derived from the population-based Prospect-European Prospective Investigation into Cancer and Nutrition (Prospect-EPIC) cohort (n = 4037) were combined.
Participants:
NGF data were from single ovaries that had been obtained postnatally for various reasons, such as elective surgery or autopsy. From the Prospect-EPIC cohort, women aged 58 years and older with a known age at natural menopause were selected.
Interventions:
There were no interventions.
Main Outcome Measure(s):
Conformity between observed age at menopause in the Prospect-EPIC cohort and NGF-predicted age at menopause from a model for age-related NGF decline constructed using a robust regression analysis. A critical threshold for NGF number was estimated by comparing the probability distribution of the age at which the NGF numbers fall below this threshold with the observed distribution of age at natural menopause from the Prospect-EPIC cohort.
Results:
The distributions of observed age at natural menopause and predicted age at natural menopause showed close conformity.
Conclusion:
The close conformity observed between NGF-predicted and actual age at natural menopause supports the hypothesis that that the size of the primordial follicle pool is an important determinant for the length of the individual ovarian life span and supports the concept of menopause prediction using ovarian reserve tests, such as anti-Müllerian hormone and antral follicle count, as derivatives of the true ovarian reserve.</abstract><cop>United States</cop><pub>Endocrine Society</pub><pmid>25915567</pmid><doi>10.1210/jc.2015-1298</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-972X |
| ispartof | The journal of clinical endocrinology and metabolism, 2015-06, Vol.100 (6), p.E845-E851 |
| issn | 0021-972X 1945-7197 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1686414640 |
| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection; Journals@Ovid Complete |
| subjects | Adolescent Adult Age Factors Aging - physiology Cell Size Child Child, Preschool Female Humans Infant Infant, Newborn Menopause - physiology Middle Aged Ovarian Follicle - cytology Ovarian Reserve - physiology Ovary - cytology Pregnancy Young Adult |
| title | The Relationship Between Variation in Size of the Primordial Follicle Pool and Age at Natural Menopause |
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