17β-estradiol suppresses lipopolysaccharide-induced acute lung injury through PI3K/Akt/SGK1 mediated up-regulation of epithelial sodium channel (ENaC) in vivo and in vitro

17β-estradiol can suppress acute lung injury (ALI) and regulate alveolar epithelial sodium channel (ENaC). However the relationship between these two functions remains unclear. This study is conducted to assess the role of ENaC and the PI3K/Akt/SGK1 signaling pathway in 17β-estradiol therapy in atte...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Respiratory research 2014-12, Vol.15, p.159-159
Hauptverfasser:	Qi, Di, He, Jing, Wang, Daoxin, Deng, Wang, Zhao, Yan, Ye, Yuan, Feng, Longhua
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Lung Injury - chemically induced Acute Lung Injury - enzymology Acute Lung Injury - prevention & control Animals Bronchoalveolar Lavage Fluid - chemistry Cell Line Cytoprotection Disease Models, Animal Endotoxins Enzyme Activation Epithelial Sodium Channels - drug effects Epithelial Sodium Channels - metabolism Estradiol - pharmacology Immediate-Early Proteins - metabolism Inflammation Mediators - metabolism Lung - drug effects Lung - enzymology Male Mice, Inbred BALB C Mice, Inbred C57BL Phosphatidylinositol 3-Kinase - antagonists & inhibitors Phosphatidylinositol 3-Kinase - metabolism Phosphorylation Protein Kinase Inhibitors - pharmacology Protein-Serine-Threonine Kinases - metabolism Proto-Oncogene Proteins c-akt - metabolism Pulmonary Edema - chemically induced Pulmonary Edema - enzymology Pulmonary Edema - prevention & control Signal Transduction - drug effects Up-Regulation
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!