Therapeutic effects of hybrid liposomes with downregulation of inflammatory cytokine for model mice of rheumatoid arthritis in vivo

Remarkably high therapeutic effects without joint swelling were obtained in CIA mouse models of RA treated with HL. [Display omitted] Therapeutic effects of HL for a collagen-induced arthritis (CIA) mouse models of HL-23 composed of 95mol% l-α-dimyristoylphosphatidylcholine (DMPC) and 5mol% polyoxye...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2015-07, Vol.25 (13), p.2686-2689
Hauptverfasser:	Ichihara, Hideaki, Yamasaki, Shuichi, Hino, Motoki, Ueoka, Ryuichi, Matsumoto, Yoko
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arthritis, Experimental - drug therapy Arthritis, Experimental - immunology Arthritis, Experimental - pathology Arthritis, Rheumatoid - drug therapy Arthritis, Rheumatoid - immunology Arthritis, Rheumatoid - pathology Chemotherapy Collagen-induced arthritis mouse models Cytokines - metabolism Dimyristoylphosphatidylcholine - therapeutic use Down-Regulation - drug effects Female Humans Hybrid liposomes In vivo Inflammation Mediators - metabolism Interleukin-1beta - metabolism Interleukin-6 - metabolism Liposomes - chemistry Liposomes - therapeutic use Mice Mice, Inbred DBA Polyethylene Glycols - therapeutic use Rheumatoid arthritis Tumor Necrosis Factor-alpha - metabolism
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