Role of 5-HT2 receptors in diabetes: Swertiamarin seco-iridoid glycoside might be a possible 5-HT2 receptor modulator
Abstract In the present review, we are focusing on modulators of 5-HT2 receptors, swertiamarin and their role in diabetes. These drugs possess both central and peripheral actions in various animal models of depression, diabetes and obesity. Swertiamarin and 5-HT2 antagonist are reported antidepressa...
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| Veröffentlicht in: | Physiology & behavior 2015-05, Vol.144, p.66-72 |
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| creator | Sonawane, Rakesh Deelip Deore, Vijaykumar B Patil, Savita D Patil, Chandragouda R Surana, Sanjay J Goyal, Ramesh K |
| description | Abstract In the present review, we are focusing on modulators of 5-HT2 receptors, swertiamarin and their role in diabetes. These drugs possess both central and peripheral actions in various animal models of depression, diabetes and obesity. Swertiamarin and 5-HT2 antagonist are reported antidepressant, hypolipidemic and beneficial in peripheral vasculopathy. In contrast to this, 5-HT2C selective agonist decreases hyperglycemia, hyperlipidemia and insulin secretogogue by action. Selective serotonin reuptake inhibitors (SSRIs) are known antidepressant having weight gain as an adverse effect. Swertiamarin has similar pharmacological actions as 5-HT2 antagonist and 5-HT2C selective agonist. This warrants that swertiamarin might modulate 5-HT2 receptors rather than affecting the uptake of serotonin. In the light of present investigation, the mechanism of these drugs can correlate the role of central and peripheral 5-HT2 receptors in diabetes. |
| doi_str_mv | 10.1016/j.physbeh.2015.02.036 |
| format | Article |
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These drugs possess both central and peripheral actions in various animal models of depression, diabetes and obesity. Swertiamarin and 5-HT2 antagonist are reported antidepressant, hypolipidemic and beneficial in peripheral vasculopathy. In contrast to this, 5-HT2C selective agonist decreases hyperglycemia, hyperlipidemia and insulin secretogogue by action. Selective serotonin reuptake inhibitors (SSRIs) are known antidepressant having weight gain as an adverse effect. Swertiamarin has similar pharmacological actions as 5-HT2 antagonist and 5-HT2C selective agonist. This warrants that swertiamarin might modulate 5-HT2 receptors rather than affecting the uptake of serotonin. In the light of present investigation, the mechanism of these drugs can correlate the role of central and peripheral 5-HT2 receptors in diabetes.</description><identifier>ISSN: 0031-9384</identifier><identifier>EISSN: 1873-507X</identifier><identifier>DOI: 10.1016/j.physbeh.2015.02.036</identifier><identifier>PMID: 25708274</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>5-HT2 receptor ; Animals ; Anti-depressant ; Antidepressive Agents - therapeutic use ; Depression - drug therapy ; Diabetes ; Diabetes Mellitus - metabolism ; Diabetes Mellitus - psychology ; Humans ; Iridoid Glucosides - chemistry ; Iridoid Glucosides - therapeutic use ; Psychiatry ; Pyrones - chemistry ; Pyrones - therapeutic use ; Receptors, Serotonin, 5-HT2 - metabolism ; Serotonin ; Signal Transduction - drug effects ; Swertiamarin and receptor modulators</subject><ispartof>Physiology & behavior, 2015-05, Vol.144, p.66-72</ispartof><rights>Elsevier Inc.</rights><rights>2015 Elsevier Inc.</rights><rights>Copyright © 2015 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-4a3acfe5f713767db64c48a4a786dbdab77f26dc845bda0a43e442939c678cad3</citedby><cites>FETCH-LOGICAL-c420t-4a3acfe5f713767db64c48a4a786dbdab77f26dc845bda0a43e442939c678cad3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0031938415001109$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25708274$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sonawane, Rakesh Deelip</creatorcontrib><creatorcontrib>Deore, Vijaykumar B</creatorcontrib><creatorcontrib>Patil, Savita D</creatorcontrib><creatorcontrib>Patil, Chandragouda R</creatorcontrib><creatorcontrib>Surana, Sanjay J</creatorcontrib><creatorcontrib>Goyal, Ramesh K</creatorcontrib><title>Role of 5-HT2 receptors in diabetes: Swertiamarin seco-iridoid glycoside might be a possible 5-HT2 receptor modulator</title><title>Physiology & behavior</title><addtitle>Physiol Behav</addtitle><description>Abstract In the present review, we are focusing on modulators of 5-HT2 receptors, swertiamarin and their role in diabetes. These drugs possess both central and peripheral actions in various animal models of depression, diabetes and obesity. Swertiamarin and 5-HT2 antagonist are reported antidepressant, hypolipidemic and beneficial in peripheral vasculopathy. In contrast to this, 5-HT2C selective agonist decreases hyperglycemia, hyperlipidemia and insulin secretogogue by action. Selective serotonin reuptake inhibitors (SSRIs) are known antidepressant having weight gain as an adverse effect. Swertiamarin has similar pharmacological actions as 5-HT2 antagonist and 5-HT2C selective agonist. This warrants that swertiamarin might modulate 5-HT2 receptors rather than affecting the uptake of serotonin. In the light of present investigation, the mechanism of these drugs can correlate the role of central and peripheral 5-HT2 receptors in diabetes.</description><subject>5-HT2 receptor</subject><subject>Animals</subject><subject>Anti-depressant</subject><subject>Antidepressive Agents - therapeutic use</subject><subject>Depression - drug therapy</subject><subject>Diabetes</subject><subject>Diabetes Mellitus - metabolism</subject><subject>Diabetes Mellitus - psychology</subject><subject>Humans</subject><subject>Iridoid Glucosides - chemistry</subject><subject>Iridoid Glucosides - therapeutic use</subject><subject>Psychiatry</subject><subject>Pyrones - chemistry</subject><subject>Pyrones - therapeutic use</subject><subject>Receptors, Serotonin, 5-HT2 - metabolism</subject><subject>Serotonin</subject><subject>Signal Transduction - drug effects</subject><subject>Swertiamarin and receptor modulators</subject><issn>0031-9384</issn><issn>1873-507X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtv1DAUhS0EotPSnwDykk3C9SNxhgWoqihFqoREi9Sd5dg3HQ9JHOyEav49Hs2AVDZ444fOOdf3u4S8ZlAyYPW7bTltdqnFTcmBVSXwEkT9jKxYo0RRgbp_TlYAghVr0cgTcprSFvISUrwkJ7xS0HAlV2T5FnqkoaNVcX3HaUSL0xxion6kzpsWZ0zv6e0jxtmbwcT8nNCGwkfvgnf0od_ZkLxDOviHzUxbpIZOISXf5tynoXQIbulNPr0iLzrTJzw_7mfk-9Wnu8vr4ubr5y-XFzeFlRzmQhphbIdVp5hQtXJtLa1sjDSqqV3rTKtUx2tnG1nlGxgpUEq-Fmtbq8YaJ87I20PuFMPPBdOsB58s9r0ZMSxJs7qpJQPgTZZWB6mN-fcROz1FnxveaQZ6T1xv9ZG43hPXwHUmnn1vjiWWdkD31_UHcRZ8PAgwN_rLY9TJehwtOp_BzDpj_G-JD_8k2N6P3pr-B-4wbcMSx0xRM52yQd_ux76fOqsAGIO1-A2iOapY</recordid><startdate>20150515</startdate><enddate>20150515</enddate><creator>Sonawane, Rakesh Deelip</creator><creator>Deore, Vijaykumar B</creator><creator>Patil, Savita D</creator><creator>Patil, Chandragouda R</creator><creator>Surana, Sanjay J</creator><creator>Goyal, Ramesh K</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150515</creationdate><title>Role of 5-HT2 receptors in diabetes: Swertiamarin seco-iridoid glycoside might be a possible 5-HT2 receptor modulator</title><author>Sonawane, Rakesh Deelip ; Deore, Vijaykumar B ; Patil, Savita D ; Patil, Chandragouda R ; Surana, Sanjay J ; Goyal, Ramesh K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-4a3acfe5f713767db64c48a4a786dbdab77f26dc845bda0a43e442939c678cad3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>5-HT2 receptor</topic><topic>Animals</topic><topic>Anti-depressant</topic><topic>Antidepressive Agents - therapeutic use</topic><topic>Depression - drug therapy</topic><topic>Diabetes</topic><topic>Diabetes Mellitus - metabolism</topic><topic>Diabetes Mellitus - psychology</topic><topic>Humans</topic><topic>Iridoid Glucosides - chemistry</topic><topic>Iridoid Glucosides - therapeutic use</topic><topic>Psychiatry</topic><topic>Pyrones - chemistry</topic><topic>Pyrones - therapeutic use</topic><topic>Receptors, Serotonin, 5-HT2 - metabolism</topic><topic>Serotonin</topic><topic>Signal Transduction - drug effects</topic><topic>Swertiamarin and receptor modulators</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sonawane, Rakesh Deelip</creatorcontrib><creatorcontrib>Deore, Vijaykumar B</creatorcontrib><creatorcontrib>Patil, Savita D</creatorcontrib><creatorcontrib>Patil, Chandragouda R</creatorcontrib><creatorcontrib>Surana, Sanjay J</creatorcontrib><creatorcontrib>Goyal, Ramesh K</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Physiology & behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sonawane, Rakesh Deelip</au><au>Deore, Vijaykumar B</au><au>Patil, Savita D</au><au>Patil, Chandragouda R</au><au>Surana, Sanjay J</au><au>Goyal, Ramesh K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of 5-HT2 receptors in diabetes: Swertiamarin seco-iridoid glycoside might be a possible 5-HT2 receptor modulator</atitle><jtitle>Physiology & behavior</jtitle><addtitle>Physiol Behav</addtitle><date>2015-05-15</date><risdate>2015</risdate><volume>144</volume><spage>66</spage><epage>72</epage><pages>66-72</pages><issn>0031-9384</issn><eissn>1873-507X</eissn><abstract>Abstract In the present review, we are focusing on modulators of 5-HT2 receptors, swertiamarin and their role in diabetes. 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| subjects | 5-HT2 receptor Animals Anti-depressant Antidepressive Agents - therapeutic use Depression - drug therapy Diabetes Diabetes Mellitus - metabolism Diabetes Mellitus - psychology Humans Iridoid Glucosides - chemistry Iridoid Glucosides - therapeutic use Psychiatry Pyrones - chemistry Pyrones - therapeutic use Receptors, Serotonin, 5-HT2 - metabolism Serotonin Signal Transduction - drug effects Swertiamarin and receptor modulators |
| title | Role of 5-HT2 receptors in diabetes: Swertiamarin seco-iridoid glycoside might be a possible 5-HT2 receptor modulator |
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