Synthesis and anti-inflammatory activity of new 1,2,4-triazole derivatives

[Display omitted] The series of new 1,2,4-triazole derivatives with methacrylic acid moiety were synthesized and characterized by NMR and IR spectroscopy as well as X-ray crystallography. The influence of newly synthesized compounds on the inflammation on the level of cytokine production and the pro...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2015-07, Vol.25 (13), p.2664-2667
Hauptverfasser:	Paprocka, Renata, Wiese, Malgorzata, Eljaszewicz, Andrzej, Helmin-Basa, Anna, Gzella, Andrzej, Modzelewska-Banachiewicz, Bozena, Michalkiewicz, Jacek
Format:	Artikel
Sprache:	eng
Schlagworte:	Amidrazone Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis Anti-Inflammatory Agents, Non-Steroidal - chemistry Anti-Inflammatory Agents, Non-Steroidal - pharmacology Cell Proliferation - drug effects Crystallography, X-Ray Cytokines - biosynthesis Drug Design Humans Ibuprofen IL-10 IL-6 In Vitro Techniques Leukocytes, Mononuclear - cytology Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - immunology Magnetic Resonance Spectroscopy PBMC Proliferation Spectrophotometry, Infrared Structure-Activity Relationship TNF-α Triazole Triazoles - chemical synthesis Triazoles - chemistry Triazoles - pharmacology
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