Morphologic changes in mice trachea, bronchi and lungs after prolonged combined radiation and inhaled chemical exposure

Investigations of morphology and morphometry of the breathing organs (trachea, bronchi and lungs) and immunogenesis of mice subject to a combined sequential exposure to fractionated external γ-irradiation by the total dose of 350 cGy and a mix of acetone, ethanol and acetaldehyde in MPCs for piloted...

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Veröffentlicht in:	Aviakosmicheskaia i Äkologicheskaia meditsina 2014, Vol.48 (5), p.13-20
Hauptverfasser:	Mukhamedieval, L N, Oganesyan, M V, Tatarkin, S V, Barantseva M Yu, Shafirkin, A V
Format:	Artikel
Sprache:	rus
Schlagworte:	Acetaldehyde - toxicity Animals Bronchi - drug effects Bronchi - radiation effects Dose-Response Relationship, Radiation Gamma Rays Mice Respiration - drug effects Respiration - radiation effects Space life sciences Trachea - drug effects Trachea - radiation effects
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creator	Mukhamedieval, L N Oganesyan, M V Tatarkin, S V Barantseva M Yu Shafirkin, A V
description	Investigations of morphology and morphometry of the breathing organs (trachea, bronchi and lungs) and immunogenesis of mice subject to a combined sequential exposure to fractionated external γ-irradiation by the total dose of 350 cGy and a mix of acetone, ethanol and acetaldehyde in MPCs for piloted spacecrafts simulating the estimated levels in crewed exploration missions were conducted. Morphologic changes in the breathing organs of animals after space missions point to immunogenesis activation and appearance of a "structural trace" as a chronic inflammation with the growth of fibrous connective tissue in tracheal, bronchial and lung walls, increase in volume fractions of glands and vessels and reduction in loose fibrous connective tissue. Formation of the fibrous connective tissue was particularly noticeable in respiratory parts of the breathing organs suggesting a high risk of long-term adverse effects.
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Morphologic changes in the breathing organs of animals after space missions point to immunogenesis activation and appearance of a "structural trace" as a chronic inflammation with the growth of fibrous connective tissue in tracheal, bronchial and lung walls, increase in volume fractions of glands and vessels and reduction in loose fibrous connective tissue. 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Morphologic changes in the breathing organs of animals after space missions point to immunogenesis activation and appearance of a "structural trace" as a chronic inflammation with the growth of fibrous connective tissue in tracheal, bronchial and lung walls, increase in volume fractions of glands and vessels and reduction in loose fibrous connective tissue. 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subjects	Acetaldehyde - toxicity Animals Bronchi - drug effects Bronchi - radiation effects Dose-Response Relationship, Radiation Gamma Rays Mice Respiration - drug effects Respiration - radiation effects Space life sciences Trachea - drug effects Trachea - radiation effects
title	Morphologic changes in mice trachea, bronchi and lungs after prolonged combined radiation and inhaled chemical exposure
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