Assessment of diagnostic criteria between primary cutaneous anaplastic large-cell lymphoma and CD30-rich transformed mycosis fungoides; a study of 66 cases
Summary Background Transformed mycosis fungoides (TMF) large cells may express CD30 antigen, and because of this, the differential diagnosis between CD30‐rich TMF and primary cutaneous anaplastic large‐cell lymphoma (cALCL) may be difficult, and especially in distinguishing cALCL associated with MF...
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| Veröffentlicht in: | British journal of dermatology (1951) 2015-06, Vol.172 (6), p.1547-1554 |
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| container_title | British journal of dermatology (1951) |
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| creator | Fauconneau, A. Pham-Ledard, A. Cappellen, D. Frison, E. Prochazkova-Carlotti, M. Parrens, M. Dalle, S. Joly, P. Viraben, R. Franck, F. Ingen-Housz-Oro, S. Giacchero, D. Jullié, M.-L. Vergier, B. Merlio, J.-P. Beylot-Barry, M. |
| description | Summary
Background
Transformed mycosis fungoides (TMF) large cells may express CD30 antigen, and because of this, the differential diagnosis between CD30‐rich TMF and primary cutaneous anaplastic large‐cell lymphoma (cALCL) may be difficult, and especially in distinguishing cALCL associated with MF vs. CD30‐rich TMF.
Objectives
To find clinical, histological and molecular diagnostic features useful for differential diagnosis between cALCL and CD30‐rich TMF. To analyse and compare the prognostic value of clinical and pathological factors in these two diseases.
Material and methods
We conducted a retrospective study (1999–2012) of 32 patients with cALCL and 34 with CD30‐rich TMF, seen in reference centres of the French Study Group of Cutaneous Lymphoma. Clinical, histological and molecular features were analysed and compared to determine their diagnostic and prognostic value.
Results
Comparison of the two groups showed that age ˃ 60 years, ≥ 5 skin lesions, early progression, absence of spontaneous regression and trunk involvement were significantly associated with the diagnosis of TMF. Abnormal T‐cell phenotype and perforin expression were significantly more frequent in cALCL (both P |
| doi_str_mv | 10.1111/bjd.13690 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1686070036</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2190234298</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4920-e97a42ae6a16606c3c2874083bedd2ab2df490dd8d84f64ff09304ba55ebd6793</originalsourceid><addsrcrecordid>eNp1kcFu1DAQhi0EotvCgRdAlrjAIe3ETpxEnMoWurAVSKiIo-XYk62XJF7sRG2ehZfF22x7QGIuc5hvfv0zPyGvUjhNY53VW3OaclHBE7KIPU9YyvlTsgCAIoFK8CNyHMIWIOWQw3NyxHKR5ZyLBflzHgKG0GE_UNdQY9Wmd2GwmmpvB_RW0RqHW8Se7rztlJ-oHgfVoxsDVb3ateqebpXfYKKxbWk7dbsb16k4NnR5wSHxVt_Qwas-NM53aGg3aRdsoM3Yb5w1GN5TRcMwmmlvQgiqVXT1gjxrVBvw5aGfkB-fPl4vV8nVt8vPy_OrRGcVgwSrQmVMoVCpECA016wsMih5jcYwVTPTZBUYU5oya0TWNFBxyGqV51gbUVT8hLyddXfe_R4xDLKzYX_KfKZMRSmgAOAiom_-Qbdu9H10J1laAeMZq8pIvZsp7V0IHht5-J1MQe4TkzExeZ9YZF8fFMc6vuaRfIgoAmczcGtbnP6vJD98uXiQTOYNGwa8e9xQ_pcUBS9y-fPrpVx_XwNbr1bymv8FGV-wgw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2190234298</pqid></control><display><type>article</type><title>Assessment of diagnostic criteria between primary cutaneous anaplastic large-cell lymphoma and CD30-rich transformed mycosis fungoides; a study of 66 cases</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Fauconneau, A. ; Pham-Ledard, A. ; Cappellen, D. ; Frison, E. ; Prochazkova-Carlotti, M. ; Parrens, M. ; Dalle, S. ; Joly, P. ; Viraben, R. ; Franck, F. ; Ingen-Housz-Oro, S. ; Giacchero, D. ; Jullié, M.-L. ; Vergier, B. ; Merlio, J.-P. ; Beylot-Barry, M.</creator><creatorcontrib>Fauconneau, A. ; Pham-Ledard, A. ; Cappellen, D. ; Frison, E. ; Prochazkova-Carlotti, M. ; Parrens, M. ; Dalle, S. ; Joly, P. ; Viraben, R. ; Franck, F. ; Ingen-Housz-Oro, S. ; Giacchero, D. ; Jullié, M.-L. ; Vergier, B. ; Merlio, J.-P. ; Beylot-Barry, M.</creatorcontrib><description>Summary
Background
Transformed mycosis fungoides (TMF) large cells may express CD30 antigen, and because of this, the differential diagnosis between CD30‐rich TMF and primary cutaneous anaplastic large‐cell lymphoma (cALCL) may be difficult, and especially in distinguishing cALCL associated with MF vs. CD30‐rich TMF.
Objectives
To find clinical, histological and molecular diagnostic features useful for differential diagnosis between cALCL and CD30‐rich TMF. To analyse and compare the prognostic value of clinical and pathological factors in these two diseases.
Material and methods
We conducted a retrospective study (1999–2012) of 32 patients with cALCL and 34 with CD30‐rich TMF, seen in reference centres of the French Study Group of Cutaneous Lymphoma. Clinical, histological and molecular features were analysed and compared to determine their diagnostic and prognostic value.
Results
Comparison of the two groups showed that age ˃ 60 years, ≥ 5 skin lesions, early progression, absence of spontaneous regression and trunk involvement were significantly associated with the diagnosis of TMF. Abnormal T‐cell phenotype and perforin expression were significantly more frequent in cALCL (both P < 0·001). Overall survival (OS) at 5 years was 77·4% for cALCL and 20·7% for CD30‐rich TMF. Stage T3, ≥ 5 skin lesions, lower limb involvement for cALCL and stage T4, extracutaneous involvement, B symptoms, high levels of lactate dehydrogenase for CD30‐rich TMF were associated with poor OS and progression‐free survival. DUSP22 gene rearrangement had no diagnostic or prognostic value.
Conclusions
Clinical features and outcome are the most discriminative to differentiate the two entities. Even histological and molecular markers were not fully specific; abnormal vs. normal T‐cell phenotype and perforin expression may constitute helpful tools.
What's already known about this topic?
The differential diagnosis between cutaneous anaplastic large‐cell lymphoma (cALCL) and CD30+ transformed mycosis fungoides (TMF) can be difficult as the two can be associated and have overlapping features.
This distinction is crucial, as both entities have a different prognosis and require different therapy.
What does this study add?
Age > 60 years, ≥ 5 skin lesions, early progression, lack of spontaneous regression and trunk involvement are suggestive of TMF, while abnormal T‐cell phenotype and perforin expression are associated with cALCL.</description><identifier>ISSN: 0007-0963</identifier><identifier>EISSN: 1365-2133</identifier><identifier>DOI: 10.1111/bjd.13690</identifier><identifier>PMID: 25645336</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Anaplastic large-cell lymphoma ; Biomarkers, Tumor - metabolism ; CD30 antigen ; Diagnosis, Differential ; Differential diagnosis ; Female ; France - epidemiology ; Fungal infections ; Gene rearrangement ; Humans ; Ki-1 Antigen - metabolism ; L-Lactate dehydrogenase ; Lactic acid ; Lymphoma ; Lymphoma, Primary Cutaneous Anaplastic Large Cell - diagnosis ; Lymphoma, Primary Cutaneous Anaplastic Large Cell - mortality ; Male ; Medical diagnosis ; Middle Aged ; Mycosis ; Mycosis fungoides ; Mycosis Fungoides - diagnosis ; Mycosis Fungoides - mortality ; Perforin ; Perforin - metabolism ; Phenotype ; Phenotypes ; Retrospective Studies ; Skin diseases ; Skin Neoplasms - diagnosis ; Skin Neoplasms - mortality ; T-Lymphocytes - pathology ; Young Adult</subject><ispartof>British journal of dermatology (1951), 2015-06, Vol.172 (6), p.1547-1554</ispartof><rights>2015 British Association of Dermatologists</rights><rights>2015 British Association of Dermatologists.</rights><rights>Copyright © 2015 British Association of Dermatologists</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4920-e97a42ae6a16606c3c2874083bedd2ab2df490dd8d84f64ff09304ba55ebd6793</citedby><cites>FETCH-LOGICAL-c4920-e97a42ae6a16606c3c2874083bedd2ab2df490dd8d84f64ff09304ba55ebd6793</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fbjd.13690$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fbjd.13690$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25645336$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fauconneau, A.</creatorcontrib><creatorcontrib>Pham-Ledard, A.</creatorcontrib><creatorcontrib>Cappellen, D.</creatorcontrib><creatorcontrib>Frison, E.</creatorcontrib><creatorcontrib>Prochazkova-Carlotti, M.</creatorcontrib><creatorcontrib>Parrens, M.</creatorcontrib><creatorcontrib>Dalle, S.</creatorcontrib><creatorcontrib>Joly, P.</creatorcontrib><creatorcontrib>Viraben, R.</creatorcontrib><creatorcontrib>Franck, F.</creatorcontrib><creatorcontrib>Ingen-Housz-Oro, S.</creatorcontrib><creatorcontrib>Giacchero, D.</creatorcontrib><creatorcontrib>Jullié, M.-L.</creatorcontrib><creatorcontrib>Vergier, B.</creatorcontrib><creatorcontrib>Merlio, J.-P.</creatorcontrib><creatorcontrib>Beylot-Barry, M.</creatorcontrib><title>Assessment of diagnostic criteria between primary cutaneous anaplastic large-cell lymphoma and CD30-rich transformed mycosis fungoides; a study of 66 cases</title><title>British journal of dermatology (1951)</title><addtitle>Br J Dermatol</addtitle><description>Summary
Background
Transformed mycosis fungoides (TMF) large cells may express CD30 antigen, and because of this, the differential diagnosis between CD30‐rich TMF and primary cutaneous anaplastic large‐cell lymphoma (cALCL) may be difficult, and especially in distinguishing cALCL associated with MF vs. CD30‐rich TMF.
Objectives
To find clinical, histological and molecular diagnostic features useful for differential diagnosis between cALCL and CD30‐rich TMF. To analyse and compare the prognostic value of clinical and pathological factors in these two diseases.
Material and methods
We conducted a retrospective study (1999–2012) of 32 patients with cALCL and 34 with CD30‐rich TMF, seen in reference centres of the French Study Group of Cutaneous Lymphoma. Clinical, histological and molecular features were analysed and compared to determine their diagnostic and prognostic value.
Results
Comparison of the two groups showed that age ˃ 60 years, ≥ 5 skin lesions, early progression, absence of spontaneous regression and trunk involvement were significantly associated with the diagnosis of TMF. Abnormal T‐cell phenotype and perforin expression were significantly more frequent in cALCL (both P < 0·001). Overall survival (OS) at 5 years was 77·4% for cALCL and 20·7% for CD30‐rich TMF. Stage T3, ≥ 5 skin lesions, lower limb involvement for cALCL and stage T4, extracutaneous involvement, B symptoms, high levels of lactate dehydrogenase for CD30‐rich TMF were associated with poor OS and progression‐free survival. DUSP22 gene rearrangement had no diagnostic or prognostic value.
Conclusions
Clinical features and outcome are the most discriminative to differentiate the two entities. Even histological and molecular markers were not fully specific; abnormal vs. normal T‐cell phenotype and perforin expression may constitute helpful tools.
What's already known about this topic?
The differential diagnosis between cutaneous anaplastic large‐cell lymphoma (cALCL) and CD30+ transformed mycosis fungoides (TMF) can be difficult as the two can be associated and have overlapping features.
This distinction is crucial, as both entities have a different prognosis and require different therapy.
What does this study add?
Age > 60 years, ≥ 5 skin lesions, early progression, lack of spontaneous regression and trunk involvement are suggestive of TMF, while abnormal T‐cell phenotype and perforin expression are associated with cALCL.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anaplastic large-cell lymphoma</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>CD30 antigen</subject><subject>Diagnosis, Differential</subject><subject>Differential diagnosis</subject><subject>Female</subject><subject>France - epidemiology</subject><subject>Fungal infections</subject><subject>Gene rearrangement</subject><subject>Humans</subject><subject>Ki-1 Antigen - metabolism</subject><subject>L-Lactate dehydrogenase</subject><subject>Lactic acid</subject><subject>Lymphoma</subject><subject>Lymphoma, Primary Cutaneous Anaplastic Large Cell - diagnosis</subject><subject>Lymphoma, Primary Cutaneous Anaplastic Large Cell - mortality</subject><subject>Male</subject><subject>Medical diagnosis</subject><subject>Middle Aged</subject><subject>Mycosis</subject><subject>Mycosis fungoides</subject><subject>Mycosis Fungoides - diagnosis</subject><subject>Mycosis Fungoides - mortality</subject><subject>Perforin</subject><subject>Perforin - metabolism</subject><subject>Phenotype</subject><subject>Phenotypes</subject><subject>Retrospective Studies</subject><subject>Skin diseases</subject><subject>Skin Neoplasms - diagnosis</subject><subject>Skin Neoplasms - mortality</subject><subject>T-Lymphocytes - pathology</subject><subject>Young Adult</subject><issn>0007-0963</issn><issn>1365-2133</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kcFu1DAQhi0EotvCgRdAlrjAIe3ETpxEnMoWurAVSKiIo-XYk62XJF7sRG2ehZfF22x7QGIuc5hvfv0zPyGvUjhNY53VW3OaclHBE7KIPU9YyvlTsgCAIoFK8CNyHMIWIOWQw3NyxHKR5ZyLBflzHgKG0GE_UNdQY9Wmd2GwmmpvB_RW0RqHW8Se7rztlJ-oHgfVoxsDVb3ateqebpXfYKKxbWk7dbsb16k4NnR5wSHxVt_Qwas-NM53aGg3aRdsoM3Yb5w1GN5TRcMwmmlvQgiqVXT1gjxrVBvw5aGfkB-fPl4vV8nVt8vPy_OrRGcVgwSrQmVMoVCpECA016wsMih5jcYwVTPTZBUYU5oya0TWNFBxyGqV51gbUVT8hLyddXfe_R4xDLKzYX_KfKZMRSmgAOAiom_-Qbdu9H10J1laAeMZq8pIvZsp7V0IHht5-J1MQe4TkzExeZ9YZF8fFMc6vuaRfIgoAmczcGtbnP6vJD98uXiQTOYNGwa8e9xQ_pcUBS9y-fPrpVx_XwNbr1bymv8FGV-wgw</recordid><startdate>201506</startdate><enddate>201506</enddate><creator>Fauconneau, A.</creator><creator>Pham-Ledard, A.</creator><creator>Cappellen, D.</creator><creator>Frison, E.</creator><creator>Prochazkova-Carlotti, M.</creator><creator>Parrens, M.</creator><creator>Dalle, S.</creator><creator>Joly, P.</creator><creator>Viraben, R.</creator><creator>Franck, F.</creator><creator>Ingen-Housz-Oro, S.</creator><creator>Giacchero, D.</creator><creator>Jullié, M.-L.</creator><creator>Vergier, B.</creator><creator>Merlio, J.-P.</creator><creator>Beylot-Barry, M.</creator><general>Blackwell Publishing Ltd</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>201506</creationdate><title>Assessment of diagnostic criteria between primary cutaneous anaplastic large-cell lymphoma and CD30-rich transformed mycosis fungoides; a study of 66 cases</title><author>Fauconneau, A. ; Pham-Ledard, A. ; Cappellen, D. ; Frison, E. ; Prochazkova-Carlotti, M. ; Parrens, M. ; Dalle, S. ; Joly, P. ; Viraben, R. ; Franck, F. ; Ingen-Housz-Oro, S. ; Giacchero, D. ; Jullié, M.-L. ; Vergier, B. ; Merlio, J.-P. ; Beylot-Barry, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4920-e97a42ae6a16606c3c2874083bedd2ab2df490dd8d84f64ff09304ba55ebd6793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anaplastic large-cell lymphoma</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>CD30 antigen</topic><topic>Diagnosis, Differential</topic><topic>Differential diagnosis</topic><topic>Female</topic><topic>France - epidemiology</topic><topic>Fungal infections</topic><topic>Gene rearrangement</topic><topic>Humans</topic><topic>Ki-1 Antigen - metabolism</topic><topic>L-Lactate dehydrogenase</topic><topic>Lactic acid</topic><topic>Lymphoma</topic><topic>Lymphoma, Primary Cutaneous Anaplastic Large Cell - diagnosis</topic><topic>Lymphoma, Primary Cutaneous Anaplastic Large Cell - mortality</topic><topic>Male</topic><topic>Medical diagnosis</topic><topic>Middle Aged</topic><topic>Mycosis</topic><topic>Mycosis fungoides</topic><topic>Mycosis Fungoides - diagnosis</topic><topic>Mycosis Fungoides - mortality</topic><topic>Perforin</topic><topic>Perforin - metabolism</topic><topic>Phenotype</topic><topic>Phenotypes</topic><topic>Retrospective Studies</topic><topic>Skin diseases</topic><topic>Skin Neoplasms - diagnosis</topic><topic>Skin Neoplasms - mortality</topic><topic>T-Lymphocytes - pathology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fauconneau, A.</creatorcontrib><creatorcontrib>Pham-Ledard, A.</creatorcontrib><creatorcontrib>Cappellen, D.</creatorcontrib><creatorcontrib>Frison, E.</creatorcontrib><creatorcontrib>Prochazkova-Carlotti, M.</creatorcontrib><creatorcontrib>Parrens, M.</creatorcontrib><creatorcontrib>Dalle, S.</creatorcontrib><creatorcontrib>Joly, P.</creatorcontrib><creatorcontrib>Viraben, R.</creatorcontrib><creatorcontrib>Franck, F.</creatorcontrib><creatorcontrib>Ingen-Housz-Oro, S.</creatorcontrib><creatorcontrib>Giacchero, D.</creatorcontrib><creatorcontrib>Jullié, M.-L.</creatorcontrib><creatorcontrib>Vergier, B.</creatorcontrib><creatorcontrib>Merlio, J.-P.</creatorcontrib><creatorcontrib>Beylot-Barry, M.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of dermatology (1951)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fauconneau, A.</au><au>Pham-Ledard, A.</au><au>Cappellen, D.</au><au>Frison, E.</au><au>Prochazkova-Carlotti, M.</au><au>Parrens, M.</au><au>Dalle, S.</au><au>Joly, P.</au><au>Viraben, R.</au><au>Franck, F.</au><au>Ingen-Housz-Oro, S.</au><au>Giacchero, D.</au><au>Jullié, M.-L.</au><au>Vergier, B.</au><au>Merlio, J.-P.</au><au>Beylot-Barry, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessment of diagnostic criteria between primary cutaneous anaplastic large-cell lymphoma and CD30-rich transformed mycosis fungoides; a study of 66 cases</atitle><jtitle>British journal of dermatology (1951)</jtitle><addtitle>Br J Dermatol</addtitle><date>2015-06</date><risdate>2015</risdate><volume>172</volume><issue>6</issue><spage>1547</spage><epage>1554</epage><pages>1547-1554</pages><issn>0007-0963</issn><eissn>1365-2133</eissn><abstract>Summary
Background
Transformed mycosis fungoides (TMF) large cells may express CD30 antigen, and because of this, the differential diagnosis between CD30‐rich TMF and primary cutaneous anaplastic large‐cell lymphoma (cALCL) may be difficult, and especially in distinguishing cALCL associated with MF vs. CD30‐rich TMF.
Objectives
To find clinical, histological and molecular diagnostic features useful for differential diagnosis between cALCL and CD30‐rich TMF. To analyse and compare the prognostic value of clinical and pathological factors in these two diseases.
Material and methods
We conducted a retrospective study (1999–2012) of 32 patients with cALCL and 34 with CD30‐rich TMF, seen in reference centres of the French Study Group of Cutaneous Lymphoma. Clinical, histological and molecular features were analysed and compared to determine their diagnostic and prognostic value.
Results
Comparison of the two groups showed that age ˃ 60 years, ≥ 5 skin lesions, early progression, absence of spontaneous regression and trunk involvement were significantly associated with the diagnosis of TMF. Abnormal T‐cell phenotype and perforin expression were significantly more frequent in cALCL (both P < 0·001). Overall survival (OS) at 5 years was 77·4% for cALCL and 20·7% for CD30‐rich TMF. Stage T3, ≥ 5 skin lesions, lower limb involvement for cALCL and stage T4, extracutaneous involvement, B symptoms, high levels of lactate dehydrogenase for CD30‐rich TMF were associated with poor OS and progression‐free survival. DUSP22 gene rearrangement had no diagnostic or prognostic value.
Conclusions
Clinical features and outcome are the most discriminative to differentiate the two entities. Even histological and molecular markers were not fully specific; abnormal vs. normal T‐cell phenotype and perforin expression may constitute helpful tools.
What's already known about this topic?
The differential diagnosis between cutaneous anaplastic large‐cell lymphoma (cALCL) and CD30+ transformed mycosis fungoides (TMF) can be difficult as the two can be associated and have overlapping features.
This distinction is crucial, as both entities have a different prognosis and require different therapy.
What does this study add?
Age > 60 years, ≥ 5 skin lesions, early progression, lack of spontaneous regression and trunk involvement are suggestive of TMF, while abnormal T‐cell phenotype and perforin expression are associated with cALCL.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>25645336</pmid><doi>10.1111/bjd.13690</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-0963 |
| ispartof | British journal of dermatology (1951), 2015-06, Vol.172 (6), p.1547-1554 |
| issn | 0007-0963 1365-2133 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1686070036 |
| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adolescent Adult Aged Aged, 80 and over Anaplastic large-cell lymphoma Biomarkers, Tumor - metabolism CD30 antigen Diagnosis, Differential Differential diagnosis Female France - epidemiology Fungal infections Gene rearrangement Humans Ki-1 Antigen - metabolism L-Lactate dehydrogenase Lactic acid Lymphoma Lymphoma, Primary Cutaneous Anaplastic Large Cell - diagnosis Lymphoma, Primary Cutaneous Anaplastic Large Cell - mortality Male Medical diagnosis Middle Aged Mycosis Mycosis fungoides Mycosis Fungoides - diagnosis Mycosis Fungoides - mortality Perforin Perforin - metabolism Phenotype Phenotypes Retrospective Studies Skin diseases Skin Neoplasms - diagnosis Skin Neoplasms - mortality T-Lymphocytes - pathology Young Adult |
| title | Assessment of diagnostic criteria between primary cutaneous anaplastic large-cell lymphoma and CD30-rich transformed mycosis fungoides; a study of 66 cases |
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