Deletion of aquaporin-4 is neuroprotective during the acute stage of micro traumatic brain injury in mice

•Two-photon microscopy was use to examine the role of AQP4 in micro TBI.•AQP4 deletion reduced cells death, astrocytes swelling and lesion volume.•Treatment inhibiting AQP4 can be used to protect micro brain injury. Micro traumatic brain injury (TBI) is the most common type of brain injury, but the...

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Veröffentlicht in:	Neuroscience letters 2015-06, Vol.598, p.29-35
Hauptverfasser:	Liang, Fengyin, Luo, Chuanming, Xu, Guangqing, Su, Fengjuan, He, Xiaofei, Long, Simei, Ren, Huixia, Liu, Yaning, Feng, Yanqing, Pei, Zhong
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Acute stage Animals Aquaporin 4 - genetics Aquaporin 4 - metabolism Aquaporin-4 (AQP4) Astrocytes - pathology Blood-Brain Barrier - metabolism Brain Edema - metabolism Brain Edema - pathology Brain Injuries - metabolism Brain Injuries - pathology Cell Death Cell Size Cerebral edema Head Injuries, Closed - metabolism Head Injuries, Closed - pathology Male Mice, Knockout Micro traumatic brain injury Microglia - pathology
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