Anti-Tumor Effect of the Mammalian Target of Rapamycin Inhibitor Everolimus in Oral Squamous Cell Carcinoma

The mammalian target of rapamycin (mTOR) has recently emerged as a promising target for therapeutic anti-cancer interventions in several human tumors. In present study, we investigated the expression of mTOR, and subsequently examined its relationship with clinicopathological factors and the anti-tu...

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Veröffentlicht in:	Pathology oncology research 2015-07, Vol.21 (3), p.765-773
Hauptverfasser:	Naruse, Tomofumi, Yanamoto, Souichi, Yamada, Shin-ichi, Rokutanda, Satoshi, Kawakita, Akiko, Kawasaki, Goro, Umeda, Masahiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Apoptosis - drug effects Biomedical and Life Sciences Biomedicine Cancer Research Carcinoma, Squamous Cell - drug therapy Carcinoma, Squamous Cell - mortality Carcinoma, Squamous Cell - pathology Cell Cycle - drug effects Cell Movement - drug effects Cell Proliferation - drug effects Everolimus - pharmacology Female Follow-Up Studies Gene Expression Regulation, Neoplastic - drug effects Humans Immunoenzyme Techniques Immunology Male Middle Aged Mouth Neoplasms - drug therapy Mouth Neoplasms - mortality Mouth Neoplasms - pathology Neoplasm Invasiveness Neoplasm Staging Oncology Pathology Phosphorylation - drug effects Prognosis Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Survival Rate TOR Serine-Threonine Kinases - antagonists & inhibitors Tumor Cells, Cultured Wound Healing - drug effects
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