Serum Mac-2 binding protein levels as a novel diagnostic biomarker for prediction of disease severity and nonalcoholic steatohepatitis

Purpose Mac‐2 binding protein (Mac‐2bp) is one of the major fucosylated glycoproteins, which we identified with glycol‐proteomic analyses. We previously reported that fucosylated glycoproteins are secreted into bile, but scarcely secreted into sera in normal liver and hypothesized that the fucosylat...

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Veröffentlicht in:	Proteomics. Clinical applications 2013-10, Vol.7 (9-10), p.648-656
Hauptverfasser:	Kamada, Yoshihiro, Fujii, Hideki, Fujii, Hironobu, Sawai, Yoshiyuki, Doi, Yoshinori, Uozumi, Naofumi, Mizutani, Kayo, Akita, Maaya, Sato, Motoya, Kida, Sachiho, Kinoshita, Noriaki, Maruyama, Nobuhiro, Yakushijin, Takayuki, Miyazaki, Masanori, Ezaki, Hisao, Hiramatsu, Naoki, Yoshida, Yuichi, Kiso, Shinichi, Imai, Yasuharu, Kawada, Norifumi, Takehara, Tetsuo, Miyoshi, Eiji
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, Neoplasm - blood Antigens, Neoplasm - metabolism Ballooning hepatocyte Biomarkers - blood Biomarkers - metabolism Case-Control Studies Cell Line Female Fucose - metabolism Humans Liver fibrosis Mac-2bp/90K Male Membrane Glycoproteins - blood Membrane Glycoproteins - metabolism Middle Aged N-glycan NASH/NAFLD Non-alcoholic Fatty Liver Disease - blood Non-alcoholic Fatty Liver Disease - diagnosis Prognosis
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