Construction of Escherichia coli strains producing l-serine from glucose

l -Serine is usually produced from glycine. We have genetically engineered Escherichia coli to produce l -serine from glucose intracellularly. d -3-Phosphoglycerate dehydrogenase (PGDH, EC 1.1.1.95) in E. coli catalyzes the first committed step in l -serine formation but is inhibited by l -serine. T...

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Veröffentlicht in:	Biotechnology letters 2012-08, Vol.34 (8), p.1525-1530
Hauptverfasser:	Li, Yu, Chen, Gu-Kui, Tong, Xin-Wei, Zhang, Hui-Tu, Liu, Xiao-Guang, Liu, Yi-Han, Lu, Fu-Ping
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Applied Microbiology Biochemistry Biological and medical sciences Biomedical and Life Sciences Biosynthesis Biotechnology Deletion Drying E coli Enzymes Escherichia coli Escherichia coli - enzymology Escherichia coli - genetics Escherichia coli - metabolism Escherichia coli Proteins - metabolism Fundamental and applied biological sciences. Psychology Gene Knockout Techniques Genes Genetic engineering Genetic Engineering - methods Glucose Glucose - metabolism L-Serine Dehydratase - metabolism Life Sciences Microbiology Mutagenesis, Site-Directed Original Research Paper Phosphoglycerate Dehydrogenase - metabolism Residues Serine - metabolism
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