Effects of surface modification of PLGA-PEG-PLGA nanoparticles on loperamide delivery efficiency across the blood–brain barrier

In this study, we developed a nanoparticle system for drug delivery across the blood–brain barrier (BBB). The nanoparticle consisting of loperamide and poly(lactide-co-glycolide)-poly(ethylene glycol)-poly(lactide-co-glycolide) (PLGA-PEG-PLGA) triblock copolymer were prepared by the nanoprecipitatio...

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Veröffentlicht in:	Journal of biomaterials applications 2013-03, Vol.27 (7), p.909-922
Hauptverfasser:	Chen, Yung-Chu, Hsieh, Wen-Yuan, Lee, Wen-Fu, Zeng, Ding-Tai
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antidiarrheals - administration & dosage Antidiarrheals - pharmacokinetics Blood-brain barrier Blood-Brain Barrier - metabolism Brain Cell Line Drug Carriers - chemistry Drug delivery systems Drugs Lactic Acid - chemistry Loperamide - administration & dosage Loperamide - pharmacokinetics Male Mice Nanoparticles Nanoparticles - chemistry Nanostructure Penetration Poloxamer - chemistry Polyethylene Glycols - chemistry Polyglycolic Acid - chemistry Polysorbates - chemistry Rats Surface Properties Surface-Active Agents - chemistry Surfactants
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