Enhancing tumor-specific intracellular delivering efficiency of cell-penetrating peptide by fusion with a peptide targeting to EGFR

Cell-penetrating peptides (CPPs) are well known as intracellular delivery vectors. However, unsatisfactory delivery efficiency and poor specificity are challenging barriers to CPP applications at the clinical trial stage. Here, we showed that S3, an EGFR-binding domain derived from vaccinia virus gr...

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Veröffentlicht in:	Amino acids 2015-05, Vol.47 (5), p.997-1006
Hauptverfasser:	Nguyen, Long The, Yang, Xu-Zhong, Du, Xuan, Wang, Jia-Wei, Zhang, Rui, Zhao, Jian, Wang, Fu-Jun, Dong, Yang, Li, Peng-Fei
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Analytical Chemistry Antimicrobial Cationic Peptides - genetics Antimicrobial Cationic Peptides - metabolism Antitumor agents Binding Biochemical Engineering Biochemistry Biomedical and Life Sciences Blood Proteins - genetics Blood Proteins - metabolism Carrier Proteins - genetics Carrier Proteins - metabolism Cell fusion Cell Line, Tumor Cell surface Cell Survival - drug effects Cell-Penetrating Peptides - genetics Cell-Penetrating Peptides - metabolism Cell-Penetrating Peptides - pharmacology Cloning, Molecular Conjugation Domains Dose-Response Relationship, Drug Drug delivery Drug delivery systems Drug Delivery Systems - methods Efficiency Epidermal growth factor Epidermal growth factor receptors ErbB Receptors - genetics ErbB Receptors - metabolism Escherichia coli - genetics Escherichia coli - metabolism Gene Expression Growth factors HEK293 Cells Heparan sulfate Heparan sulfate proteoglycans Heparan Sulfate Proteoglycans - chemistry Heparan Sulfate Proteoglycans - metabolism Heparin Humans Intercellular Signaling Peptides and Proteins Internalization Intracellular Life Sciences Low level Mathematical analysis Metastases Molecular Sequence Data Molecular Targeted Therapy Neurobiology Organ Specificity Original Article Peptides Peptides - genetics Peptides - metabolism Pinocytosis Protein Structure, Tertiary Proteoglycans Proteomics Recombinant Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Recombinant Fusion Proteins - pharmacology Selectivity Tat protein Time Factors Tumor cells Tumors Uptakes Vaccinia virus - chemistry Vectors (mathematics)
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