Development of poly(N-isopropylacrylamide)/alginate copolymer hydrogel-grafted fabrics embedding of berberine nanosuspension for the infected wound treatment
In the present study, a novel hydrogel-grafted fabrics embedding of berberine nanosuspension was developed for the treatment of infected wound. Hydrogel-grafted fabric was prepared by graft copolymerization of N-isopropylacrylamide and alginate using ceric ammonium nitrate as initiator. Berberine na...
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| Veröffentlicht in: | Journal of biomaterials applications 2014-05, Vol.28 (9), p.1376-1385 |
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| container_title | Journal of biomaterials applications |
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| creator | Xu, He Yuan, Xu-Dong Shen, Bao-De Han, Jin Lv, Qing-Yuan Dai, Ling Lin, Ming-Gui Yu, Chao Bai, Jin-Xia Yuan, Hai-Long |
| description | In the present study, a novel hydrogel-grafted fabrics embedding of berberine nanosuspension was developed for the treatment of infected wound. Hydrogel-grafted fabric was prepared by graft copolymerization of N-isopropylacrylamide and alginate using ceric ammonium nitrate as initiator. Berberine nanosuspension was prepared and embedded in the hydrogel-grafted fabrics to achieve sustained drug release. The prepared hydrogel-grafted fabrics embedding of berberine nanosuspension was characterized by FT-IR spectroscopy, scanning electron microscopy, and swelling degree studies. Fourier transform infrared spectroscopy revealed that berberine was embedded into the matrix of hydrogel-grafted fabrics, rather than on the surface. Scanning electron microscopy showed that a thin hydrogel layer was formed on the surface of nonwoven fibers. The swelling study showed that hydrogel-grafted fabric had water absorbing characteristic with reversible temperature sensitivity. The drug release study demonstrated that hydrogel-grafted fabrics can be used as a sustained drug delivery system of hydrophobic compounds. The berberine nanosuspension embedded hydrogel-grafted fabric was further investigated in an animal infected wound model and was found to be a very promising wound healing dressing for the treatment and healing of infected wounds. |
| doi_str_mv | 10.1177/0885328213509503 |
| format | Article |
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Hydrogel-grafted fabric was prepared by graft copolymerization of N-isopropylacrylamide and alginate using ceric ammonium nitrate as initiator. Berberine nanosuspension was prepared and embedded in the hydrogel-grafted fabrics to achieve sustained drug release. The prepared hydrogel-grafted fabrics embedding of berberine nanosuspension was characterized by FT-IR spectroscopy, scanning electron microscopy, and swelling degree studies. Fourier transform infrared spectroscopy revealed that berberine was embedded into the matrix of hydrogel-grafted fabrics, rather than on the surface. Scanning electron microscopy showed that a thin hydrogel layer was formed on the surface of nonwoven fibers. The swelling study showed that hydrogel-grafted fabric had water absorbing characteristic with reversible temperature sensitivity. The drug release study demonstrated that hydrogel-grafted fabrics can be used as a sustained drug delivery system of hydrophobic compounds. The berberine nanosuspension embedded hydrogel-grafted fabric was further investigated in an animal infected wound model and was found to be a very promising wound healing dressing for the treatment and healing of infected wounds.</description><identifier>ISSN: 0885-3282</identifier><identifier>EISSN: 1530-8022</identifier><identifier>DOI: 10.1177/0885328213509503</identifier><identifier>PMID: 24163330</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Absorption ; Acrylic Resins - chemistry ; Alginates ; Alginates - chemistry ; Berberine - administration & dosage ; Drug delivery systems ; Drugs ; Fabrics ; Glucuronic Acid - chemistry ; Hexuronic Acids - chemistry ; Hydrogels ; Infection - etiology ; Infection - therapy ; Microscopy, Electron, Scanning ; Nanoparticles ; Nanostructure ; Particle Size ; Scanning electron microscopy ; Spectroscopy, Fourier Transform Infrared ; Swelling ; Wounds and Injuries - complications ; Wounds and Injuries - therapy</subject><ispartof>Journal of biomaterials applications, 2014-05, Vol.28 (9), p.1376-1385</ispartof><rights>The Author(s) 2013 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c403t-c02a185aa8d174449c218130837cc6c3e0278e5323915326bf525750e266964a3</citedby><cites>FETCH-LOGICAL-c403t-c02a185aa8d174449c218130837cc6c3e0278e5323915326bf525750e266964a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/0885328213509503$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/0885328213509503$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21799,27903,27904,43600,43601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24163330$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xu, He</creatorcontrib><creatorcontrib>Yuan, Xu-Dong</creatorcontrib><creatorcontrib>Shen, Bao-De</creatorcontrib><creatorcontrib>Han, Jin</creatorcontrib><creatorcontrib>Lv, Qing-Yuan</creatorcontrib><creatorcontrib>Dai, Ling</creatorcontrib><creatorcontrib>Lin, Ming-Gui</creatorcontrib><creatorcontrib>Yu, Chao</creatorcontrib><creatorcontrib>Bai, Jin-Xia</creatorcontrib><creatorcontrib>Yuan, Hai-Long</creatorcontrib><title>Development of poly(N-isopropylacrylamide)/alginate copolymer hydrogel-grafted fabrics embedding of berberine nanosuspension for the infected wound treatment</title><title>Journal of biomaterials applications</title><addtitle>J Biomater Appl</addtitle><description>In the present study, a novel hydrogel-grafted fabrics embedding of berberine nanosuspension was developed for the treatment of infected wound. Hydrogel-grafted fabric was prepared by graft copolymerization of N-isopropylacrylamide and alginate using ceric ammonium nitrate as initiator. Berberine nanosuspension was prepared and embedded in the hydrogel-grafted fabrics to achieve sustained drug release. The prepared hydrogel-grafted fabrics embedding of berberine nanosuspension was characterized by FT-IR spectroscopy, scanning electron microscopy, and swelling degree studies. Fourier transform infrared spectroscopy revealed that berberine was embedded into the matrix of hydrogel-grafted fabrics, rather than on the surface. Scanning electron microscopy showed that a thin hydrogel layer was formed on the surface of nonwoven fibers. The swelling study showed that hydrogel-grafted fabric had water absorbing characteristic with reversible temperature sensitivity. The drug release study demonstrated that hydrogel-grafted fabrics can be used as a sustained drug delivery system of hydrophobic compounds. The berberine nanosuspension embedded hydrogel-grafted fabric was further investigated in an animal infected wound model and was found to be a very promising wound healing dressing for the treatment and healing of infected wounds.</description><subject>Absorption</subject><subject>Acrylic Resins - chemistry</subject><subject>Alginates</subject><subject>Alginates - chemistry</subject><subject>Berberine - administration & dosage</subject><subject>Drug delivery systems</subject><subject>Drugs</subject><subject>Fabrics</subject><subject>Glucuronic Acid - chemistry</subject><subject>Hexuronic Acids - chemistry</subject><subject>Hydrogels</subject><subject>Infection - etiology</subject><subject>Infection - therapy</subject><subject>Microscopy, Electron, Scanning</subject><subject>Nanoparticles</subject><subject>Nanostructure</subject><subject>Particle Size</subject><subject>Scanning electron microscopy</subject><subject>Spectroscopy, Fourier Transform Infrared</subject><subject>Swelling</subject><subject>Wounds and Injuries - complications</subject><subject>Wounds and Injuries - therapy</subject><issn>0885-3282</issn><issn>1530-8022</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUtv1TAQhS0EopfCnhXysixCx29nicpTqmAD68hxJqmrxA52UnR_DP-VRLewQEIgWfZivnM0PoeQ5wxeMWbMJVirBLecCQW1AvGAHJgSUFng_CE57ONqn5-RJ6XcAoCqpX5MzrhkWggBB_LjDd7hmOYJ40JTT-c0Hi8-VaGkOaf5ODqft2sKHb68dOMQoluQ-rRjE2Z6c-xyGnCshuz6BTvauzYHXyhOLXZdiMNu2mLeTohIo4uprGXGWEKKtE-ZLjdIQ-zR7_LvaY0dXTK6Zd_oKXnUu7Hgs_v3nHx99_bL1Yfq-vP7j1evrysvQSyVB-6YVc7ZjhkpZe05s0yAFcZ77QUCNxa3pES9xcN12yuujALkWtdaOnFOLk6-26e_rViWZgrF4zi6iGktDdNWWQZG23-jiksJRjD-Hygz1rJaiQ2FE-pzKiVj38w5TC4fGwbNXnXzZ9Wb5MW9-9pO2P0W_Op2A6oTUNyAzW1ac9wy_LvhT8u_siA</recordid><startdate>20140501</startdate><enddate>20140501</enddate><creator>Xu, He</creator><creator>Yuan, Xu-Dong</creator><creator>Shen, Bao-De</creator><creator>Han, Jin</creator><creator>Lv, Qing-Yuan</creator><creator>Dai, Ling</creator><creator>Lin, Ming-Gui</creator><creator>Yu, Chao</creator><creator>Bai, Jin-Xia</creator><creator>Yuan, Hai-Long</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7SR</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>F28</scope><scope>JG9</scope><scope>L7M</scope></search><sort><creationdate>20140501</creationdate><title>Development of poly(N-isopropylacrylamide)/alginate copolymer hydrogel-grafted fabrics embedding of berberine nanosuspension for the infected wound treatment</title><author>Xu, He ; Yuan, Xu-Dong ; Shen, Bao-De ; Han, Jin ; Lv, Qing-Yuan ; Dai, Ling ; Lin, Ming-Gui ; Yu, Chao ; Bai, Jin-Xia ; Yuan, Hai-Long</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c403t-c02a185aa8d174449c218130837cc6c3e0278e5323915326bf525750e266964a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Absorption</topic><topic>Acrylic Resins - chemistry</topic><topic>Alginates</topic><topic>Alginates - chemistry</topic><topic>Berberine - administration & dosage</topic><topic>Drug delivery systems</topic><topic>Drugs</topic><topic>Fabrics</topic><topic>Glucuronic Acid - chemistry</topic><topic>Hexuronic Acids - chemistry</topic><topic>Hydrogels</topic><topic>Infection - etiology</topic><topic>Infection - therapy</topic><topic>Microscopy, Electron, Scanning</topic><topic>Nanoparticles</topic><topic>Nanostructure</topic><topic>Particle Size</topic><topic>Scanning electron microscopy</topic><topic>Spectroscopy, Fourier Transform Infrared</topic><topic>Swelling</topic><topic>Wounds and Injuries - complications</topic><topic>Wounds and Injuries - therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xu, He</creatorcontrib><creatorcontrib>Yuan, Xu-Dong</creatorcontrib><creatorcontrib>Shen, Bao-De</creatorcontrib><creatorcontrib>Han, Jin</creatorcontrib><creatorcontrib>Lv, Qing-Yuan</creatorcontrib><creatorcontrib>Dai, Ling</creatorcontrib><creatorcontrib>Lin, Ming-Gui</creatorcontrib><creatorcontrib>Yu, Chao</creatorcontrib><creatorcontrib>Bai, Jin-Xia</creatorcontrib><creatorcontrib>Yuan, Hai-Long</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Journal of biomaterials applications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xu, He</au><au>Yuan, Xu-Dong</au><au>Shen, Bao-De</au><au>Han, Jin</au><au>Lv, Qing-Yuan</au><au>Dai, Ling</au><au>Lin, Ming-Gui</au><au>Yu, Chao</au><au>Bai, Jin-Xia</au><au>Yuan, Hai-Long</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Development of poly(N-isopropylacrylamide)/alginate copolymer hydrogel-grafted fabrics embedding of berberine nanosuspension for the infected wound treatment</atitle><jtitle>Journal of biomaterials applications</jtitle><addtitle>J Biomater Appl</addtitle><date>2014-05-01</date><risdate>2014</risdate><volume>28</volume><issue>9</issue><spage>1376</spage><epage>1385</epage><pages>1376-1385</pages><issn>0885-3282</issn><eissn>1530-8022</eissn><abstract>In the present study, a novel hydrogel-grafted fabrics embedding of berberine nanosuspension was developed for the treatment of infected wound. Hydrogel-grafted fabric was prepared by graft copolymerization of N-isopropylacrylamide and alginate using ceric ammonium nitrate as initiator. Berberine nanosuspension was prepared and embedded in the hydrogel-grafted fabrics to achieve sustained drug release. The prepared hydrogel-grafted fabrics embedding of berberine nanosuspension was characterized by FT-IR spectroscopy, scanning electron microscopy, and swelling degree studies. Fourier transform infrared spectroscopy revealed that berberine was embedded into the matrix of hydrogel-grafted fabrics, rather than on the surface. Scanning electron microscopy showed that a thin hydrogel layer was formed on the surface of nonwoven fibers. The swelling study showed that hydrogel-grafted fabric had water absorbing characteristic with reversible temperature sensitivity. The drug release study demonstrated that hydrogel-grafted fabrics can be used as a sustained drug delivery system of hydrophobic compounds. The berberine nanosuspension embedded hydrogel-grafted fabric was further investigated in an animal infected wound model and was found to be a very promising wound healing dressing for the treatment and healing of infected wounds.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>24163330</pmid><doi>10.1177/0885328213509503</doi><tpages>10</tpages></addata></record> |
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| ispartof | Journal of biomaterials applications, 2014-05, Vol.28 (9), p.1376-1385 |
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| language | eng |
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| subjects | Absorption Acrylic Resins - chemistry Alginates Alginates - chemistry Berberine - administration & dosage Drug delivery systems Drugs Fabrics Glucuronic Acid - chemistry Hexuronic Acids - chemistry Hydrogels Infection - etiology Infection - therapy Microscopy, Electron, Scanning Nanoparticles Nanostructure Particle Size Scanning electron microscopy Spectroscopy, Fourier Transform Infrared Swelling Wounds and Injuries - complications Wounds and Injuries - therapy |
| title | Development of poly(N-isopropylacrylamide)/alginate copolymer hydrogel-grafted fabrics embedding of berberine nanosuspension for the infected wound treatment |
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